HLA Typing for Transplant Market by Technology (PCR (SSO, SSP, Real Time), Sequencing (NGS, Sanger)), Product (Instrument, Kits, Software), Application (Antibody Screening), Type (Organ Transplant, Tissue), End User, and Region - Global Forecast to 2028
The global HLA typing for transplant market in terms of revenue was estimated to be worth $0.8 billion in 2023 and is poised to reach $1.1 billion by 2028, growing at a CAGR of 6.3% from 2023 to 2028. The new research study consists of an industry trend analysis of the market. The new research study consists of industry trends, pricing analysis, patent analysis, conference and webinar materials, key stakeholders, and buying behaviour in the market. Growth in the HLA typing for transplants market is mainly driven by factors such as the increasing number of transplantations worldwide, rising technological advancements in the field of HLA typing, and increasing public-private funding for target research activities. Moreover, government initiatives to promote organ donations increase the accessibility of transplant procedures, and commercialization high resolution HLA typing assay.
Attractive Opportunities in the HLA typing for transplants Market
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HLA Typing for Transplant Market Dynamics
Driver: Increasing number of transplant procedures globally
HLA matching provides numerous benefits in organ transplantation, including fewer rejection episodes, reduced immunosuppression, better graft function, and longer graft survival. The steady rise in the number of transplant procedures has increased the demand for timely and accurate HLA typing, thus bolstering the demand for instruments and kits.
- According to the United Network for Organ Sharing (UNOS), in the US, organ transplant procedures increased from 39,701 in 2019 to 42,800 in 2022.
- In the UK, kidney transplant procedures increased from 2,567 in 2020 to 3,192 in 2022 (Source: Global Observatory on Donation and Transplantation (GODT).
- According to the Australian Donation and Transplantation Activity Report 2022, the number of kidney organ transplant recipients in Australia increased by 11% from 2021 (1,173) to 2022 (1,224).
This growth in procedural volumes and patient pool will ensure a sustained demand for donor-recipient HLA profiling and compatibility testing to eliminate the risk of immune rejection.
Restraint: High costs of molecular tests used for HLA typing procedures
HLA typing procedures for histocompatibility tests are conducted through specialized molecular diagnostic platforms that consist of several advanced technologies, such as NGS instruments to achieve the desired process outcomes, reduce cycle times, and increase sample throughput. However, innovative diagnostic instruments require significant capital investments and extensive scientific validation for market commercialization. For instance, NGS is a novel platform that integrates device automation and microfluidics for high sample throughput and effective genomic detection. The demand for premium-priced NGS-based assays is limited due to the preference for affordable or low-priced non-molecular assay techniques for HLA typing in transplant diagnostic testing owing to budget constraints.
OPPORTUNITY: Technological shift from non-molecular serological assays to gene-based HLA profiling
Traditionally, the donor-recipient screening process was carried out through the serology-based assay technique before a transplantation procedure. However, gene-based histocompatibility testing procedures have recently been increasingly preferred over serology-based assays. Molecular assay requires less analysis time, provides higher sample throughput, offers easy handling of multiple samples in one run, and requires a smaller amount of patient samples than serological assay techniques, thus increasing the adoption of molecular assay technologies for HLA profiling in transplant donor patients.
CHALLENGE: Significant gap between organ availability and demand
There is a; considerable shortage of organs from donors in comparison to the high demand for organ transplants. The increasing number of waiting list of organ tranplants has become a vhalalneging factor for HLA typing for transplant market.
HLA Typing For Transplant Market Ecosystem
Prominent companies in HLA typing for transplant market include Thermo Fisher Scientific (US), Illumina, Inc. (US), QIAGEN (Germany), CareDX (US),F. Hoffmann-La Roche Ltd. (Switzerland),Bio-Rad Laboratories, Inc. (US), Immucor, Inc. (US), and Luminex Corporation (US)
In 2022, reagents & consumables to dominate the HLA typing for transplant industry, product & Service.
Based on the product & service, the HLA typing for transplant market is segmented into reagents & consumables, instruments, and software & services. In 2022, the reagents & consumables accounted for the largest share of the HLA typing for transplants market. The higher utilization and repeated use of reagents & kits in HLA typing by diagnostic laboratories & transplant centers growing demand for identification of accurate HLA alleles are likely to drive the the growth of the reagents & consumables segment.
In 2022, the molecular assay technologies segment accounted for the largest share of the HLA typing for transplant industry, by technology.
The HLA typing for transplant market, by technology, is segmented into molecular and non-molecular assay technologies. In 2022, the molecular assay technologies segment accounted for the largest share of the HLA typing for the transplants market. Molecular techniques, such as PCR and NGS allow for high-resolution HLA typing, and faster turnaround to analyze and identify multiple alleles at HLA loci in comparison to traditional serology technology are likely to support the growth of the segment.
In 2022, The independent reference laboratories end-user segment accounted for the largest share of the HLA typing for transplant industry
Based on end-user, the HLA typing for transplant market is segmented into hospitals & transplant centers, independent reference laboratories, and research laboratories & academic institutes. In 2022, independent reference laboratories accounted for the largest share of the HLA typing for the transplants market. The large share of this segment can be attributed to the presence of advanced molecular technology offering high-resolution HLA typing, the growing number of reference laboratories offering HLA service, strong emphasis of reference of laboratories on investments in advanced HLA typing equipment in the field of HLA typing.
In 2022, North America to dominate in HLA typing for transplant industry
The HLA typing for transplant market is segmented into North America, Europe, Asia Pacific, Latin America and Middle-East Africa. North America is expected to dominate during the forecast period, primarily due surge in transplant procesures, well establish healthcare infrastructure, high adoption of advanced diagnostic technologies, favoriable reimbursement policy, and strong presence of key manufactures offering high resolution HLA typing assays.
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The HLA typing for transplant market is dominated by players such as Thermo Fisher Scientific (US), Illumina, Inc. (US), QIAGEN (Germany), CareDX (US), F. Hoffmann-La Roche Ltd. (Switzerland), Bio-Rad Laboratories, Inc. (US)
Scope of the HLA Typing for Transplant Industry:
Report Metric |
Details |
Market Revenue in 2023 |
$0.8 billion |
Estimated Value by 2028 |
$1.1 billion |
Revenue Rate |
Poised to grow at a CAGR of 6.3% |
Market Driver |
Increasing number of transplant procedures globally |
Market Opportunity |
Technological shift from non-molecular serological assays to gene-based HLA profiling |
This research report categorizes the HLA typing for transplant market to forecast revenue and analyze trends in each of the following submarkets:
By Product & Service
- Reagents & Consumables
- Instruments
- Software & Services
By Technology
-
Molecular Assay Technologies
-
PCR-Based Molecular Assays
- Real-time PCR
- Sequence-specific Primer-PCR
- Sequence-specific Oligonucleotide-PCR
- Other PCR-based Molecular Assays
-
Sequencing-based Molecular Assays
- Sanger Sequencing
- Next-generation Sequencing
- Other Sequencing-based Molecular Assays
-
PCR-Based Molecular Assays
- Non-molecular Assay Technologies
By Application
-
Diagnostic Applications
- Antibody Screening
- Chimerism Monitoring
- Others
- Research Applications
By Transplant Type
- Solid Organ Transplant
- Soft Tissue Transplant
By End User
- Independent Reference Laboratories
- Hospitals & Transplant Centers
- Research Laboratories & Academic Institutes
By Region
-
North America
- US
- Canada
-
Europe
- Germany
- France
- UK
- Italy
- Spain
- Rest of Europe
-
Asia Pacific
- Japan
- China
- India
- Australia
- South Korea
- Rest of Asia Pacific
-
Latin America
- Brazil
- Mexico
- Rest of Latin America
- Middle-East Africa
Recent Developments of HLA Typing for Transplant Industry
- In September 2023, Omixon, Inc. (US) launched its NanoTYPE RUO Multiplex Human Leukocyte Antigen Amplification kit compatible with Oxford Nanopore’s MinION Platform.
- In November 2022, Illumina, Inc. (US) opened a new state-of-the-art Solutions Center in Dubai for expanding genomics research in Middle East
- In March 2022, 021, Immucor, Inc. (US) launched MIA FORA NGS Express HLA Typing Software.
Frequently Asked Questions (FAQ):
What is the projected market revenue value of the global HLA typing for transplant market?
The global HLA typing for transplant market boasts a total revenue value of $1.1 billion by 2028.
What is the estimated growth rate (CAGR) of the global HLA typing for transplant market?
The global HLA typing for transplant market has an estimated compound annual growth rate (CAGR) of 6.3% and a revenue size in the region of $0.8 billion in 2023.
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This study involved the extensive use of both primary and secondary sources. The research process involved the study of various factors affecting the industry to identify the segmentation types, industry trends, key players, competitive landscape, key market dynamics, and key player strategies.
Secondary Research
The secondary research process involves the widespread use of secondary sources, directories, databases (such as Bloomberg Businessweek, Factiva, and D&B Hoovers), white papers, annual reports, company house documents, investor presentations, and SEC filings of companies. Secondary research was used to identify and collect information useful for the extensive, technical, market-oriented, and commercial study of the HLA typing for the transplants market. It was also used to obtain important information about the key players and market classification & segmentation according to industry trends to the bottom-most level and key developments related to market and technology perspectives. A database of the key industry leaders was also prepared using secondary research.
Primary Research
In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include industry experts such as CEOs, vice presidents, marketing and sales directors, technology & innovation directors, and related key executives from various key companies and organizations in the HLA typing for transplants market. The primary sources from the demand side include medical OEMs, CDMOs, and service providers, among others. Primary research was conducted to validate the market segmentation, identify key players in the market, and gather insights on key industry trends & key market dynamics.
A breakdown of the primary respondents is provided below:
*Others include sales managers, marketing managers, business development managers, product managers, distributors, and suppliers.
Note: Companies are classified into tiers based on their total revenue. As of 2022, Tier 1 = >USD 10.00 billion, Tier 2 = USD 1.00 billion to USD 10.00 billion, and Tier 3 = <USD 1.00 billion.
To know about the assumptions considered for the study, download the pdf brochure
Market Estimation Methodology
In this report, the global HLA typing for transplants market size was arrived at by using the revenue share analysis of leading players. For this purpose, key players in the market were identified, and their revenues from the HLA typing for transplants business were determined through various insights gathered during the primary and secondary research phases. Secondary research included the study of the annual and financial reports of the top market players. In contrast, primary research included extensive interviews with key opinion leaders, such as CEOs, directors, and key marketing executives.
To calculate the global market value, segmental revenues were calculated based on the revenue mapping of major solution/service providers. This process involved the following steps:
- Generating a list of major global players/OEMs operating in the HLA typing for transplants market
- Mapping the annual revenue generated by major global players from the HLA typing segment (or the nearest reported business unit/product category)
- Revenue mapping of top players to cover at least ~75% of the global market share as of 2022
- Extrapolation of the revenue mapping of major players to derive the global value of the market
- Extrapolating the global value of the HLA typing for transplants industry
Data Triangulation
After arriving at the overall market size from the market size estimation process explained above, the global HLA typing for transplants market was split into segments and subsegments. Data triangulation and market breakdown procedures were employed to complete the overall market engineering process and arrive at the exact statistics for all segments and subsegments. The data was triangulated by studying various factors and trends from both the demand and supply sides. Additionally, the HLA typing for transplants market was validated using both top-down and bottom-up approaches.
Market Definition
HLA typing tests for transplant procedures are used to identify HLA antigens in accessing the transplant donor-recipient compatibility to avoid the risk of immune rejection in a recipient. These procedures are adopted for donor-recipient cross-matching, subject profiling, genotyping, and other related diagnostic purposes. Advancements in HLA typing technology allowing high resolution typing, and providing accurate analysis of HLA alleles reduce the risk of rejection or graft-versus-host disease, making transplantation a more viable option for patients.
Key Market Stakeholders
- Manufacturers of HLA typing products for transplant
- Distributors of HLA typing products for transplant
- Hospitals, Transplant Centers, reference laboratories, Cord Blood Banks
- Research laboratories and Academic Institutes
- Organ Procurement Organizations (OPOs)
- Non-government organizations
- Government regulatory authorities
- Contract manufacturers and third-party suppliers
- Clinical research organizations (CROs)
- Government and non-governmental regulatory authorities
- Market research and consulting firms
Objectives of the Study
- To define, describe, and forecast the HLA typing for transplants market on the basis of product & service, technology, application, transplant type , end user, and region
- To provide detailed information regarding the major factors influencing the growth potential of the global HLA typing for transplants market (drivers, restraints, opportunities, challenges, and trends).
- To analyze the micro markets with respect to individual growth trends, future prospects, and contributions to the global HLA typing for transplants market.
- To analyze key growth opportunities in the global HLA typing for transplants market for key stakeholders and provide details of the competitive landscape for market leaders.
- To forecast the size of market segments and/or subsegments with respect to four major regions, namely, North America (US and Canada), Europe (Germany, France, the UK, Italy, Spain, and the RoE), Asia Pacific (Japan, China, India, Australia, South Korea, ASEAN region and the RoAPAC), and Rest of the world.
- To profile the key players in the global HLA typing for transplants market and comprehensively analyze their market shares and core competencies.
- To track and analyze the competitive developments undertaken in the global HLA typing for transplants market, such as product launches, agreements, expansions, and & acquisitions.
Available Customizations
With the given market data, MarketsandMarkets offers customizations as per the company’s specific needs. The following customization options are available for the present global HLA typing for transplants market report:
Product Analysis
- Product matrix, which gives a detailed comparison of the product portfolios of the top fifteen companies
Company Information
- Detailed analysis and profiling of additional market players (up to 15)
Geographic Analysis
- Further breakdown of the Rest of Europe's HLA typing for transplants market into Russia, Belgium, the Netherlands, Switzerland, Austria, Finland, Sweden, Poland, and Portugal, among other
- Further breakdown of the Rest of Asia Pacific HLA typing for transplants market into Singapore, Taiwan, New Zealand, Philippines, Malaysia, and other APAC countries.
Growth opportunities and latent adjacency in HLA Typing for Transplant Market