HOME Top Market Reports In-Vitro Toxicology Testing Market by Industry (Diagnostic, Pharmaceutical, Cosmetics, Chemical), Technology (Cell Culture, HTS, Omics), Applications (Systemic, Dermal, Ocular), Method (Cellular Assay, Ex vivo, In Silico) - Global Forecast to 2018

In-Vitro Toxicology Testing Market by Industry (Diagnostic, Pharmaceutical, Cosmetics, Chemical), Technology (Cell Culture, HTS, Omics), Applications (Systemic, Dermal, Ocular), Method (Cellular Assay, Ex vivo, In Silico) - Global Forecast to 2018

By: marketsandmarkets.com
Publishing Date: April 2014
Report Code: BT 2373

 

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The global in-vitro toxicology testing market is estimated to reach $17,227 million by 2018 at a CAGR of 13.5% during the forecast period (2013–2018). The market will witness a double-digit growth attributed to the increasing acceptance of in vitro methods over in vivo ones. Government support to stop animal testing, new and promising technologies, and advancement in new approaches are significant factors propelling the market in the forecast period. On the other hand, predictive ability of in vitro testing and limitation of the methods to replicate true in vivo conditions are the factors that hinder the market. The government programs such as the TOX 21 initiated by the U.S. government and growing number of drug discoveries and innovations globally represent an opportunity for the growth of the market.

However, reluctance of regulatory authorities to consider alternate methods for proving safety and efficacy will obstruct market growth. Of all the industries, pharmaceutical industry had the largest market share in 2013, whereas cosmetic industry will be the fastest-growing market in the coming five years. The rising pressure to reduce the drug attrition rates to curb the drug development costs, and the timeline in the pharmaceutical industry has led to the increased adoption of in vitro methods in the detection of potential toxic effects much earlier in the development path. The pharmaceutical industry has been witnessing a tremendous growth as a result of government initiatives such as AXLR8 program that was initiated by the European Union. The cosmetic industry will grow the fastest owing to the amendment of European Union’s Cosmetics Directive that has set forth ban on the use of animals in testing for any toxic effects of beauty products.

Cell culture technology accounted for the largest share of the global in-vitro toxicology testing market in 2013. This segment will also witness the fastest growth from 2013 to 2018. Cell culture technology is gaining acceptance as the necessary tool to determine toxicity in earlier stages of drug development. With the introduction of 3D models the cell based assays will further observe strong growth.

The methods considered for the study are cellular assays, biochemical assays, ex vivo, and in silico. The cellular assays are expected to grow rapidly in the forecast period 2013 - 2018. The cell based assays can predict more precisely the response of the human body to chemicals than animal cells. As a result these models have become a new trend in the market.

Under the applications, systemic toxicity market accounted for the largest share of the overall in vitro toxicology testing market in 2013. The insistent requirement to detect cardiotoxicity and liver toxicity, that are the prime reasons of toxicity caused by any drug, is propelling the market growth.

Geographic analysis reveals that Europe was the largest contributor to the global in vitro toxicology testing market in 2013. It will also be the fastest growing region till 2018. The European market is witnessing growth as a result of strong government directives to altogether stop animal testing and replace in vivo testing by in vitro methods. The Asian countries, on the other hand, are also expected to register double-digit growth from 2013 to 2018 due to the low costs offered by the developing nations to conduct studies.

The key players in the market are Agilent Technologies (U.S.), Alere, Inc. (U.S.), Bio-Rad (U.S.), BioReliance (Sigma Aldrich) (U.S.), Catalent Pharma Solutions (U.S.), Charles River Laboratories (U.S.), Covance (U.S.), Cyprotex (U.K.), Eurofins Scientific, Inc (U.S.), GE Healthcare (U.K.), Life Technologies Corporation (Thermo Fisher Scientific) (U.S.), and Quest Diagnostics (U.S.).

Scope of the Report

The definition of the in vitro toxicology testing for the sake of this market study is as follows:

In-vitro toxicology testing involves scientific analysis to access safety and risk evaluation for elucidating mechanisms of toxicity, and/or demonstrating the biological process involved in a toxic response to a xenobiotic, including drugs.

Both, product and service markets are in the scope of this report. However, the report does not cover assay volumes market.

Particulars

Scope

Geography

  • North America
  • Europe
  • Asia
  • RoW (Latin America, Middle East, Africa, and Pacific countries)

Historical Years

2011–2012

Base Year

2013

Forecast Period

2014–2018

Revenue Currency

USD ($)

This research report categorizes the global in-vitro toxicology testing market into the following segments:

  • By Industry:
    • Diagnostics
      • By sample
        • Urine
        • Alcohol
        • Oral
        • Hair
        • Others (Sweat, blood, endocrine, cotinine and stomach contents screening)
      • By type
        • Forensics (Hospital and Diagnostics)
        • Workplace drug testing (Drug abuse testing)
    • Pharmaceuticals
    • Chemicals
    • Cosmetics
    • Food
  • By Technology:
    • Cell Culture
    • HTS
    • Imaging
    • OMICS
  • By Application:
    • Systemic Toxicity
    • Dermal Toxicity

Customization options

A. In-vitro toxicology testing Market, by Product Type

  1. Introduction
  2. Consumables
    1. Reagents & assay kits
      1. Cell Growth Assays
      2. Cell Death Assays
      3. Second Messenger Assays
      4. Reporter Gene Assays
      5. Other Assays
    2. Microplates
    3. Cell lines
      1. Immortalized Cell Lines
      2. Primary Cell Lines
      3. Stem Cell Lines
    4. Other consumables
  3. Instruments
    1. Detection & screening instruments
      1. Microplate Readers
      2. Flow Cytometers
      3. Fluorescent Microscopes
      4. High Content Screening Instruments
      5. Label-Free Detection Instruments
      6. Other Detection and Screening Instruments
    2. Automation & high throughput screening instruments
  4. Software
  5. Services

B. In-vitro toxicology testing Market, by Screening Models

  1. Introduction
  2. Skin equivalent models for toxicity testing
    1. Cell models reproducing the skin
  3. Screening model for cardiovascular toxicity
    1. Stem cell applications for cardiotoxicity testing
  4. Screening model for liver toxicity
    1. Primary cell models reproducing the liver
    2. Stem cell applications for hepatotoxicity testing
  5. Screening models for kidney toxicity
    1. Primary cell models reproducing the kidney
  6. Screening model for ocular toxicity
    1. The potential role of primary cell cultures in the vision
    2. The potential role of stem cell applications in the vision
  7. Others

C. Product Analysis

A detailed comparison of product portfolio of top five companies through Product Matrix that will assist in allocating investment (e.g. in product development, promotion) across the portfolio

Additional 5 companies can be profiled apart from those profiled in the report

Table Of Contents
 
1 Introduction (Page No. - 21)
   1.1 Objectives Of The Study
   1.2 Report Description
   1.3 Markets Covered
   1.4 Stakeholders
   1.5 Market Scope
   1.6 Research Methodology
        1.6.1 Market Size Estimation & Data Triangulation
        1.6.2 Key Data Points From Secondary Sources
        1.6.3 Key Data Points From Primary Sources
        1.6.4 Assumptions

2 Executive Summary (Page No. - 34)

3 Premium Insights (Page No. - 40)
   3.1 Market Size
   3.2 Market Dynamics
   3.3 In-Vitro Toxicity Testing Market Size Snapshot
   3.4 In-Vitro Toxicity Testing, Geographic Analysis By Industry
   3.5 In-Vitro Toxicity Testing Market Size, By Technology
   3.6 In-Vitro Toxicity Testing Market Size, By Method
   3.7 In-Vitro Toxicity Testing Market, By Application

4 Market Overview (Page No. - 47)
   4.1 Introduction
   4.2 Market Segmentation
   4.3 Market Dynamics
        4.3.1 Drivers
               4.3.1.1 Dearth Of Publicly Accessible Databases to Facilitate The Use Of In Vitro Test Methods
               4.3.1.2 New and Promising Technologies to Propel Market
               4.3.1.3 Technological Advancements and Shifting Focus to Innovative Approaches Of 3d Cell Cultures Are Driving The Cell Culture Technology Market
               4.3.1.4 Opposition to Animal Testing Will Help Shift The Focus to In Vitro Testing
        4.3.2 Restraints
               4.3.2.1 Technological Disadvantages Associated With In Vitro Tests Limit Their Use
               4.3.2.2 In Vitro Models Cannot Detect Autoimmunity and Immunostimulation
               4.3.2.3 Predictive Ability Of In Vitro Testing Leads to Decreasing Adoption Of These Tests
        4.3.3 Opportunities
               4.3.3.1 The Toxicology In The 21st Century (Tox21) Program
               4.3.3.2 Increasing Drug Discovery and Innovation and Modernization in The Market
               4.3.3.3 Growing Demand For In Vitro Toxicology in The European Market
        4.3.4 Threats
               4.3.4.1 Reluctance Of Regulatory Authorities to Consider Alternate Methods For Proving Safety and Efficacy
   4.4 Burning Issues
        4.4.1 Validation Of New In Vitro Methods
        4.4.2 Differences in Opinion Between The U.S. and Eu Regulatory Authorities
   4.5 Winning Imperatives
        4.5.1 3d Human Hepatocyte Models to Boost The In Vitro Testing Market

5 By Industry (Page No. - 60)
   5.1 Introduction
   5.2 Diagnostics
        5.2.1 Diagnostics, By Type
               5.2.1.1 Forensics
               5.2.1.2 Drug Abuse & Workplace Drug Testing
        5.2.2 Diagnostics, By Sample
               5.2.2.1 Urine Screening
               5.2.2.2 Alcohol Screening
               5.2.2.3 Oral Fluid Screening
               5.2.2.4 Hair Screening
               5.2.2.5 Others
   5.3 Cosmetics & Household Products
   5.4 Pharmaceutical Industry
   5.5 Chemicals Industry
   5.6 Food Industry

6 By Technology (Page No. - 86)
   6.1 Introduction
        6.1.1 Cell Culture Technology
               6.1.1.1 Primary Monolayer and Three-Dimensional Cell Cultures
        6.1.2 High Throughput Technologies
               6.1.2.1 High Throughput Toxicity Testing
               6.1.2.2 The Epa Toxcast Program
        6.1.3 Molecular Imaging Technologies
               6.1.3.1 Molecular Imaging Technologies
               6.1.3.2 High Content Imaging Technologies
        6.1.4 Omics Technologies
               6.1.4.1 Genomics
               6.1.4.2 Toxicogenomics
               6.1.4.3 Proteomics
               6.1.4.4 Metabolomics

7 By Application (Page No. - 108)
   7.1 Introduction
   7.2 Systemic Toxicity
   7.3 Dermal Toxicity
   7.4 Ocular Toxicity
   7.5 Endocrine Disruption (Reproductive/Developmental Toxicity)
   7.6 Others (Admet, Organ-Specific Toxicity, Drug-Drug Interactions, Target/Pathway Assays, & Ecotoxicity)
        7.6.1 Admet (Pharmacokinetics & Metabolism Testing)
        7.6.2 Organ-Specific Toxicity
        7.6.3 Drug-Drug Interactions
        7.6.4 Target/Pathway Assays
        7.6.5 Ecotoxicity

8 By Method (Page No. - 124)
   8.1 Introduction
   8.2 Cellular Assays
   8.3 Biochemical Assays
   8.4 In Silico Methods
   8.5 Ex Vivo Models

9 Geographic Analysis (Page No. - 137)
   9.1 Introduction
   9.2 Europe
   9.3 North America
   9.4 Asia
   9.5 Rest Of The World (ROW)

10 Competitive Landscape (Page No. - 168)
   10.1 Introduction
   10.2 Competitive Landscape, 2011-March 2014
   10.3 New Product Launches
   10.4 Mergers & Acquisitions
   10.5 Agreements, Partnerships & Collaborations
   10.6 Expansions
   10.7 Other Developments

11 Company Profiles (Business Overview, Products & Services, Key Strategy, Recent Developments, Mnm View)* (Page No. - 191)
   11.1 Agilent Technologies, Inc.
   11.2 Alere, Inc.
   11.3 Bio-Rad Laboratories, Inc.
   11.4 Bioreliance, Inc. (A Subsidiary Of Sigma-Aldrich Corporation)
   11.5 Catalent
   11.6 Charles River Laboratories International, Inc.
   11.7 Covance, Inc.
   11.8 Cyprotex
   11.9 Eurofins Scientific
   11.1 GE Healthcare
   11.11 Life Technologies Corporation (Thermo Fisher Scientific)
   11.12 Quest Diagnostics
 
*Details On Products & Services, Key Strategy, & Recent Developments Might Not Be Captured in Case Of Unlisted Companies.


List Of Tables (67 Tables)

Table 1 In-Vitro Toxicology/Toxicity Testing, By Geography, 2011-2013 ($Million)
Table 2 Global Market, By Industry, 2011–2018 ($Million)
Table 3 Global Market For Diagnostics Industry, By Type, 2011–2018 ($Million)
Table 4 In Vitro Toxicology Testing Market For Diagnostics Industry, By Geography, 2011–2018 ($Million)
Table 5 In-Vitro Toxicology Testing Market For Forensics, By Geography, 2011–2018 ($Million)
Table 6 Market For Drug Abuse & Workplace Drug Testing, By Geography, 2011–2018 ($Million)
Table 7 Market For Diagnostics Industry, By Sample, 2011–2018 ($Million)
Table 8 Urine Sample Testing Market, By Geography, 2011–2018 ($Million)
Table 9 Alcohol Sample Testing Market, By Geography, 2011–2018 ($Million)
Table 10 Oral Sample Testing Market, By Geography, 2011–2018 ($Million)
Table 11 Hair Sample Testing Market, By Geography, 2011–2018 ($Million)
Table 12 Others Sample Testing Market, By Geography, 2011–2018 ($Million)
Table 13 In Vitro Toxicology Testing Market For Cosmetics & Household Industry, By Geography, 2011–2018 ($Million)
Table 14 In Vitro Toxicology Testing Market For Pharmaceutical Industry, By Geography, 2011–2018 ($Million)
Table 15 Market For Chemical Industry, By Geography, 2011–2018 ($Million)
Table 16 Market For Food Industry, By Geography, 2011–2018 ($Million)
Table 17 Global In Vitro Toxicology Testing Market, By Technology, 2011–2018 ($Million)
Table 18 In-Vitro Toxicology Testing Market For Cell Culture Technology, By Geography, 2011–2018 ($Million)
Table 19 Global In-Vitro Toxicology Testing Market For Cell Culture Technology, By Industry, 2011–2018 ($Million)
Table 20 In Vitro Toxicology Testing Market For High Throughput Technology, By Geography, 2011–2018 ($Million)
Table 21 Global Market For High Throughput Technology, By Industry, 2011–2018 ($Million)
Table 22 Market For Molecular Imaging Technology, By Geography, 2011–2018 ($Million)
Table 23 Global Market For Molecular Imaging Technology, By Industry, 2011–2018 ($Million)
Table 24 Market For Omics Technologies, By Geography, 2011–2018 ($Million)
Table 25 Global Market For Omics Technologies, By Industry, 2011–2018 ($Million)
Table 26 Global  Market, By Application, 2011–2018 ($Million)
Table 27 In Vitro Toxicity Testing Market For Systemic Toxicology, By Geography, 2011–2018 ($Million)
Table 28 Market For Dermal Toxicology, By Geography, 2011–2018 ($Milllion)
Table 29 Market For Ocular Toxicology, By Geography, 2011–2018 ($Milllion)
Table 30 Market For Endocrine Disruption, By Geography, 2011–2018 ($Milllion)
Table 31 Market For Other Applications, By Geography, 2011–2018 ($Milllion)
Table 32 In-Vitro Toxicology Testing Market, By Method, 2011–2018 ($Million)
Table 33 Primary Cell Culture Advantages & Limitations
Table 34 In Vitro Toxicity Testing Market For Cellular Assays, By Geography, 2011–2018 ($Million)
Table 35 In Vitro Toxicity Testing Market For Biochemical Assays, By Geography, 2011–2018 ($Million)
Table 36 In Vitro Toxicity Testing Market For In Silico Methods, By Geography, 2011–2018 ($Million)
Table 37 In Vitro Toxicity Testing Market For Ex Vivo Methods, By Geography, 2011–2018 ($Million)
Table 38 In Vitro Toxicology Market, By Geography, 2011–2018 ($Million)
Table 39 Europe: Market, By Industry, 2011–2018 ($Million)
Table 40 Europe: Market For Diagnostics Industry, By Sample, 2011–2018 ($Million)
Table 41 Europe: Market For Diagnostics Industry, By Type, 2011–2018 ($Million)
Table 42 Europe: Market, By Technology, 2011–2018 ($Million)
Table 43 Europe: Market, By Method, 2011–2018 ($Million)
Table 44 Europe: Market, By Application, 2011–2018 ($Million)
Table 45 North America: Market, By Industry, 2011–2018 ($Million)
Table 46 North America: Market For Diagnostics Industry, By Sample, 2011–2018 ($Million)
Table 47 North America: In Vitro Toxicology Testing Market For Diagnostics Industry, By Type, 2011–2018 ($Million)
Table 48 North America: Market, By Technology, 2011–2018 ($Million)
Table 49 North America: Market, By Method, 2011–2018 ($Million)
Table 50 North America: Market, By Application, 2011–2018 ($Million)
Table 51 Asia: Market, By Industry, 2011–2018 ($Million)
Table 52 Asia: Market For Diagnostics Industry, By Sample, 2011–2018 ($Million)
Table 53 Asia: Market For Diagnostics Industry, By Type, 2011–2018 ($Million)
Table 54 Asia: Market, By Technology, 2011–2018 ($Million)
Table 55 Asia: Market, By Method, 2011–2018 ($Million)
Table 56 Asia: Market, By Application, 2011–2018 ($Million)
Table 57 ROW: Market, By Industry, 2011–2018 ($Million)
Table 58 ROW: Market For Diagnostics Industry, By Sample, 2011–2018 ($Million)
Table 59 ROW: Market For Diagnostics Industry, By Type, 2011–2018 ($Million)
Table 60 ROW: Market, By Technology, 2011–2018 ($Million)
Table 61 ROW: Market, By Method, 2011–2018 ($Million)
Table 62 ROW: Market, By Application, 2011–2018 ($Million)
Table 63 New Product Launches, 2011–2014
Table 64 Mergers & Acquisitions, 2011–2014
Table 65 Agreements, Partnerships, & Collaborations, 2011–2014
Table 66 Expansions, 2011–2014
Table 67 Other Developments, 2011–2014
 
 
List Of Figures (25 Figures)

Figure 1 Market Crackdown & Data Triangulation
Figure 2 Market Forecasting Model
Figure 3 In Vitro Toxicology Testing, By Industry, 2013 ($Million)
Figure 4 Global Market, By Technology, 2013 ($Million)
Figure 5 Market Size, ($Million)
Figure 6 Market Dynamics
Figure 7 Market Size Snapshot, 2013 ($Million)
Figure 8 Geographic Analysis, By Industry, 2013 ($Million)
Figure 9 Global Market Size, By Technology, 2013 ($Million)
Figure 10 Global Market Size, By Method, 2013 ($Million)
Figure 11 Opportunity Matrix: Global Market, By Application, 2013
Figure 12 Market Crackdown & Data Triangulation
Figure 13 Global Market, By Industry,2013 ($Million)
Figure 14 Global Market, By Technology, 2013 Vs 2018 ($Million)
Figure 15 Primary Cell Cultures Advantages & Disadvantages
Figure 16 High Throughput Technology Advantages & Disadvantages
Figure 17 Molecular Imaging Technologies Advantages & Disadvantages
Figure 18 High Content Imaging Technologies Advantages & Disadvantages
Figure 19 Genomics Advantages & Disadvantages
Figure 20 Proteomics Advantages & Disadvantages
Figure 21 Metabolomics Advantages & Disadvantages
Figure 22 Global Market, By Application, 2013 ($Million)
Figure 23 Opportunity Matrix: Global Market, By Method, 2013
Figure 24 In Vitro Toxicology Testing Market, By Geography, 2013
Figure 25 Key Growth Stratagies, 2011–March 2014

The global market of in-vitro toxicology testing is subdivided into industry, technology, method, application and geography. On the basis of industry, the market is further segmented into diagnostics, pharmaceuticals, chemicals, cosmetics, and food. Diagnostics is further categorized into sample and type. The largest market share was captured by the pharmaceutical industry, whereas cosmetics industry was the fastest growing industry with a double digit CAGR. The prime factor contributing to the growth of pharmaceutical industry has been the attention towards the detection of toxicity during earlier stages of development.

On the basis of technology, the global market of in vitro toxicology testing is divided into cell culture, high throughput screening, cellular imaging, and omics technologies. Cell culture technology will witness the maximum growth rate in the coming years.

The methods considered for the study are cellular assays, biochemical assays, ex vivo and in silico. Cellular assays market is estimated to grow at a double digit CAGR during the forecast period (2013–2018). Cellular assays can predict the biological properties of potential drug compounds. These assays can also detect and measure cell viability, functionality and growth.

Under the applications, the market is segmented into systemic toxicity, dermal toxicity, ocular toxicity, endocrine disruption (reproductive & developmental toxicity) and others. Systemic toxicity testing was the largest segment in 2013. The increasing focus on detection of toxicity in earlier stages of development is leading to persistent requirement for human cell-based in vitro models for cardiotoxicity and liver toxicity testing which are the major reasons for drug attrition.

Europe commanded the largest share of the global in-vitro toxicology testing market in 2013. This is attributed to the support provided by the European government for anti-animal testing laws. The government has further put ban on the production and sale of all animal tested cosmetics across the continent.

The market will be driven by increasing acceptance of in-vitro toxicology testing methods as alternatives to in vivo toxicology testing. The new technologies in the in vitro testing market help in investigating the adverse effects of environmental agents in a more mechanistic and time saving manner. Organizations such as REACH foresee that more results of in vitro and in silico methods will be included in risk assessment which will promote the use of in vitro methods for toxicology testing.

The market is dominated by Agilent Technologies (U.S.), Alere, Inc. (U.S.), Bio-Rad (U.S.), Catalent Pharma Solutions (U.S.), Charles River Laboratories (U.S.), Covance (U.S.), Cyprotex (U.K.), Eurofins Scientific, Inc (U.S.), GE Healthcare (U.K.), Life Technologies Corporation (Thermo Fisher Scientific) (U.S.), and Quest Diagnostics (U.S.).

Global in vitro toxicology testing market size snapshot, 2013 ($Million)

In-Vitro Toxicology/ Toxicity Testing Market

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