HOME Top Market Reports Single Use Bioreactor Market by Product Type (Recombinant Proteins, Monoclonal Antibodies), Cell Type (Bacteria, Yeast), Technology (Stirred SUB, Single Use Bubble Column Bioreactor), End User(Bio pharmaceutical Manufacturers) - Global Forecast to 2019

Single Use Bioreactor Market by Product Type (Recombinant Proteins, Monoclonal Antibodies), Cell Type (Bacteria, Yeast), Technology (Stirred SUB, Single Use Bubble Column Bioreactor), End User(Bio pharmaceutical Manufacturers) - Global Forecast to 2019

By: marketsandmarkets.com
Publishing Date: October 2014
Report Code: BT 2863

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The single use bioreactor (SUB) market is estimated to grow at a CAGR of 18.4% to reach $470.9 million by 2019. Wave-induced motion SUBs form the largest segment of the SUB market. Biologics manufacturing is expected to be the fastest-growing end-user segment for this market.

This report segments the global single use bioreactor market by molecule type, type of cell, technology, end user, and region. On the basis of molecule type, the market is segmented into monoclonal antibodies (MAbs), vaccines, gene therapy, recombinant proteins, stem cells, and others (growth factors, interferons, antisense, RNA interference). MAbs accounted for the largest share ~35% of the overall market in 2014, owing to the increasing demand for SUBs in small-scale manufacturing of MAbs.

The type of cell segment is further segmented into mammalian cell, bacterial cell, yeast cell and others (insect cell and plant cell). Mammalian cells form the fastest-growing segment of the single use bioreactor market, by type of cell. The high growth rate of this market can be attributed to the high compatibility of biologics derived from mammalian cells.

The technology segment is further segmented into wave-induced motion SUBs, stirred SUBs, single-use bubble column bioreactors, and others (single-use reactors with vertically perforated discs and single-use hybrid reactors). The wave-induced motion SUB segment is estimated to grow the fastest, on account of its higher adoption rate.

On the basis of end users, the market is categorized into R&D (CROs, biopharmaceutical manufacturers, and research institutes) and biopharmaceutical manufacturers. R&D departments are the major end users of the SUB market in 2014, because of the reduced complexity of these bioreactors and their lower cost as compared to traditional/stainless steel bioreactors.

The overall growth of the market is propelled by an improved in return on investment for small companies and startups, reduced cost and complexity in automation and cost, and lesser requirement of validation and cleaning between processes. The market is further driven by factors such as energy efficiency of SUBs and ease of cultivation of marine organisms, such as algae. The high growth of biologics market provides new growth opportunities to players in the single use bioreactor market. However, limitations related to scaling, issues regarding leachables and extractable, and difficulties in meeting good manufacturing practices (GMP) standards are limiting the growth of this market. In addition, the need for improved single-use sensors and limitations in the flexibility of plastic bags used in SUBs are the key market challenges.

A thorough analysis of this market identified limitations in scaling and its effect on the limited adoption rate of SUB in full-scale manufacturing as burning issues in the SUB market. On the other hand, the shift in the focus of bio manufacturing companies towards single-use technologies, including bioreactors, to address the growing demand for biologics was identified as a winning imperative.

Key players operating in the single use bioreactor market are Thermo Fischer Scientific, Inc. (U.S.), Sartorius AG (Germany), Merck KGaA (Germany), GE Healthcare (U.S.) and Pall Corporation (U.S.).

Scope of the Report

The volume and accessories market is not covered in this market report.

Single Use Bioreactor Market

Market Segmentation

This research report categorizes the single use bioreactor market on the basis of molecule type, type of cell, technology, end users, and geographies

SUB Market, by Molecule Type

  • Monoclonal Antibodies
  • Vaccines
  • Recombinant Proteins
  • Gene Therapy
  • Stem Cells
  • Others ( Growth Factors, interferons, antisense, and RNA interference)

SUB Market, by Type of Cell

  • Mammalian Cells
  • Bacteria
  • Yeast
  • Others (Insect and Plant Cells)

SUB Market, by Technology

  • Wave-induced Motion SUBs
  • Stirred SUBs
  • Single-use Bubble-column Bioreactors
  • Others (single-use reactors with vertically perforated discs and single-use hybrid reactors)

SUB Market, by End User

  • R&D Department (CROs, Biopharmaceutical Manufacturers, Research Institutes)
  • Biopharmaceutical Manufacturers

SUB Market, by Region

  • North America
  • Europe
  • Asia-Pacific
  • RoW (Rest of the World)

Table of Contents 
 
1 Introduction (Page No. - 15)
  1.1 Objectives Of The Study
  1.2 Market Definition
  1.3 Market Scope
      1.3.1 Limitation Of The Study
      1.3.2 Markets Covered
  1.4 Stakeholders
  1.5 Years Considered In The Study
  1.6 Currency

2 Research Methodology (Page No. - 19)
  2.1 Market Size Estimation
  2.2 Market Crackdown And Data Triangulation
      2.2.1 Key Data From Secondary Sources
      2.2.2 Key Data From Primary Sources
            2.2.2.1 Key Industry Insights
      2.2.3 Assumptions

3 Executive Summary (Page No. - 25)

4 Premium Insights (Page No. - 29)
  4.1 Attractive Market Opportunities In The Market
  4.2 Single Use Bioreactor Market, By Molecule Type
  4.3 Market Snapshot
  4.4 SUB Market, By Technology
  4.5 SUB Market, By End User
  4.6 Lifecycle Analysis, By Region
  4.7 Asia-Pacific To Show Quickest Growth

5 Market Overview (Page No. - 34)
  5.1 Introduction
  5.2 Market Segmentation
      5.2.1 Single-Use Bioreactor Market, By Technology
      5.2.2 SUB Market, By Type Of Molecule
      5.2.3 SUB Market, By Type Of Cells
      5.2.4 SUB Market, By End User
  5.3 Market Dynamics
      5.3.1 Improved Returns On Investment For Small Companies And Startups
      5.3.2 Reduced Complexity Of Automation
      5.3.3 Ease In Cultivation Of Marine Organisms (Algae)
      5.3.4 Positive Impact On The Environment
  5.4 Restraints
      5.4.1 Regulatory Concerns Related To Single-Use Bioreactor 
      5.4.2 Issues Regarding Leachables And Extractables
      5.4.3 Difficulties In Meeting The Gmp Standards
  5.5 Challenges
      5.5.1 Limitations In Flexible Bioreactors
      5.5.2 Need For Improved Single-Use Sensors
  5.6 Opportunities
      5.6.1 Growing Biologics Market
  5.7 Winning Imperatives
      5.7.1 Growing Popularity Of Subs Among Biopharmaceutical Companies Is An Evolving Trend
  5.8 Burning Issues
      5.8.1 Stability Of Biomolecules While Shifting From Single-Use Systems To Traditional Stainless Steel Leads To Limited Adoption Of Subs

6 Industry Insights (Page No. - 43)
  6.1 Industry Insights
  6.2 Supply Chain Analysis
      6.2.1 Key Influencers
  6.3 Porter’s Five Forces Analysis
      6.3.1 Threat From New Entrants
      6.3.2 Threat From Substitutes
      6.3.3 Bargaining Power Of Suppliers
      6.3.4 Bargaining Power Of Buyers
      6.3.5 Intensity Of Competitive Rivalry
  6.4 Pestle Analysis
      6.4.1 Political Factors
      6.4.2 Economic Factors
      6.4.3 Social Factors
      6.4.4 Technological Factors
      6.4.5 Environmental Factors
      6.4.6 Legal Factors
  6.5 Industry Insights

7 Single Use Bioreactor Market, By Technology (Page No. - 49)
  7.1 Introduction
  7.2 Wave-Induced Motion Single-Use Bioreactors
  7.3 Stirred Tank Single-Use Bioreactors
  7.4 Single-Use Bubble Column Bioreactors
  7.5 Other Technologies

8 Single Use Bioreactor Market, By Molecule Type (Page No. - 56)
  8.1 Introduction
  8.2 Monoclonal Antibodies (Mabs)
  8.3 Vaccines
  8.4 Recombinant Proteins
  8.5 Stem Cells
  8.6 Gene Therapy
  8.7 Others (Growth Factors, Interferons, Antisense, And Rna Interference)

9 Single Use Bioreactor Market, By Type Of Cell (Page No. - 69)
  9.1 Introduction
  9.2 Mammalian Cells
  9.3 Bacterial Cells
  9.4 Yeast Cells
  9.5 Others (Insect Cells And Plant Cells)

10 Single Use Bioreactor Market, By End User (Page No. - 79)
   10.1 Introduction
   10.2 R&D Departments
   10.3 Biopharmaceutical Manufacturers

11 Single Use Bioreactor Market, By Geography (Page No. - 87)
   11.1 Introduction
   11.2 North America
        11.2.1 U.S.
        11.2.2 Canada
   11.3 Europe
        11.3.1 Germany
        11.3.2 U.K.
        11.3.3 Rest Of Europe (Roe)
   11.4 Asia-Pacific (Apac)
   11.5 Rest Of The World (Row)

12 Competitive Landscape (Page No. - 114)
   12.1 Overview
   12.2 Market Share Analysis, Global Single-Use Bioreactor Market
   12.3 New Product Launches
   12.4 Agreements & Partnerships
   12.5 Acquisitions
   12.6 Expansions
   12.7 Other Developments

13 Company Profiles (Page No. - 124)
   13.1 Introduction
   13.2 Applikon Biotechnology
   13.3 Cellexus Limited
   13.4 Cellution Biotech
   13.5 Ge Healthcare (Subsidiary Of General Electric Company)
   13.6 Merck Kgaa
   13.7 Pall Corporation
   13.8 Parker Hannifin Corporation
   13.9 Pbs Biotech, Inc.
   13.10 Sartorius Ag
   13.11 Thermo Fisher Scientific, Inc.
*Details On Financials, Products & Services, Key Strategy, & Recent Developments Might Not Be Captured In Case Of Unlisted Companies. 

14 Appendix (Page No. - 152)
   14.1 Insights Of Industry Experts
   14.2 Discussion Guide
   14.3 Introducing Rt: Real-Time Market Intelligence
   14.4 Available Customizations
   14.5 Related Reports 
  
 List of Tables  (85 Tables)

Table 1 Single Use Bioreactor Market Size, By Technology, 2012–2019 ($Million) 
Table 2 Wave-Induced Motion Single-Use Bioreactors Market Size, By Region, 2012–2019 ($Million)
Table 3 Stirred Tank Single Use Bioreactor Market Size, By Region, 2012–2019 ($Million) 
Table 4 Single-Use Bubble Column Bioreactors Market Size, By Region, 2012–2019 ($Million) 
Table 5 Single-Use Bioreactors Other Technologies Market Size, By Region, 2012–2019 ($Million)
Table 6 Market Size, By Molecule Type, 2012–2019 ($Million) 
Table 7 Single Use Bioreactor Monoclonal Antibodies Market Size, By Region, 2012–2019 ($Million)
Table 8 North America: SUB Monoclonal Antibodies Market Size, By Country, 2012–2019 ($Million)
Table 9 Europe: SUB Monoclonal Antibodies Market Size, By Country, 2012–2019 ($Million) 
Table 10 Single-Use Bioreactors Vaccines Market Size, By Region, 2012–2019 ($Million) 
Table 11 North America: SUB Vaccines Market Size, By Country, 2012–2019 ($Million) 
Table 12 Europe: SUB Vaccines Market Size, By Country, 2012–2019 ($Million)
Table 13 Single-Use Bioreactors Recombinant Proteins Market Size, By Region, 2012–2019 ($Million) 
Table 14 North America: Single-Use Bioreactors Recombinant Proteins Market Size, By Country, 2012–2019 ($Million)
Table 15 Europe: Single-Use Bioreactors Recombinant Proteins Market Size, By Country, 2012–2019 ($Million) 
Table 16 Single-Use Bioreactors Stem Cells Market Size, By Region, 2012–2019 ($Million) 
Table 17 North America: Single Use Bioreactor Stem Cells Market Size, By Country, 2012–2019 ($Million) 
Table 18 Europe: Single Use Bioreactor Stem Cells Market Size, By Country, 2012–2019 ($Million)
Table 19 Single Use Bioreactor Gene Therapy Market Size, By Region, 2012–2019 ($Million) 
Table 20 North America: Single Use Bioreactor Gene Therapy Market Size, By Country, 2012–2019 ($Million) 
Table 21 Europe: Single Use Bioreactor Gene Therapy Market Size, By Country, 2012–2019 ($Million) 
Table 22 Single Use Bioreactor Other Molecules Market Size, By Region, 2012–2019 ($Million) 
Table 23 North America: Single Use Bioreactors Other Molecules Market Size, By Country, 2012–2019 ($Million)
Table 24 Europe: Single Use Bioreactor Other Molecules Market Size, By Country, 2012–2019 ($Million) 
Table 25 Single Use Bioreactor Market Size, By Type Of Cell, 2012–2019 ($Million) 
Table 26 Single Use Bioreactor Market Size For Mammalian Cells, By Region, 2012–2019 ($Million) 
Table 27 North America: Market Size For Mammalian Cells, By Country, 2012–2019 ($Million)
Table 28 Europe: Market Size For Mammalian Cells, By Country, 2012–2019 ($Million) 
Table 29 Single-Use Bioreactors Market Size For Bacterial Cells, By Region, 2012–2019 ($Million)
Table 30 North America: Market Size For Bacterial Cells, By Country, 2012–2019 ($Million)
Table 31 Europe: Market Size For Bacterial Cells, By Country, 2012–2019 ($Million) 
Table 32 Europe Will Continue To Lead Single Use Bioreactor Market For Yeast Cells
Table 33 Single Use Bioreactor Market Size For Yeast Cells, By Region, 2012–2019 ($Million) 
Table 34 North America: Market Size For Yeast Cells, By Country, 2012–2019 ($Million) 
Table 35 Europe: Market Size For Yeast Cells, By Country, 2012–2019 ($Million) 
Table 36 Single Use Bioreactor Market Size For Other Cells, By Region, 2012–2019 ($Million) 
Table 37 North America: Market Size For Other Cells, By Country, 2012–2019 ($Million) 
Table 38 Europe: Market Size For Other Cells, By Country, 2012–2019 ($Million) 
Table 39 Market Size, By End User, 2012–2019 ($Million)
Table 40 Single-Use Bioreactors R&D Departments Market Size, By Region, 2012–2019 ($Million) 
Table 41 North America: Single-Use Bioreactors R&D Departments Market Size, By Country, 2012–2019 ($Million)
Table 42 Europe: Single-Use Bioreactors R&D Departments Market Size, By Country, 2012–2019 ($Million) 
Table 43 Single-Use Bioreactors Biopharmaceutical Manufacturers Market Size, By Region, 2012–2019 ($Million)
Table 44 North America: SUB Biopharmaceutical Manufacturers Market Size, By Country, 2012–2019 ($Million)
Table 45 Europe: SUB Biopharmaceutical Manufacturers Market Size, By Country, 2012–2019 ($Million)
Table 46 Single Use Bioreactor Market Size, By Region, 2012–2019 ($Million)
Table 47 North America: Market Size, By Country, 2012–2019 ($Million) 
Table 48 North America: Market Size, By Molecule Type, 2012–2019 ($Million)
Table 49 North America: Market Size, By Type Of Cell, 2012–2019 ($Million)
Table 50 North America: Market Size, By Technology, 2012–2019 ($Million)
Table 51 North America: Market Size, By End User, 2012–2019 ($Million) 
Table 52 U.S.: Market Size, By Molecule Type, 2012–2019 ($Million) 
Table 53 U.S.: Market Size, By Type Of Cell, 2012–2019 ($Million) 
Table 54 U.S.: Market Size, By End User, 2012–2019 ($Million) 
Table 55 Canada: Market Size, By Molecule Type, 2012–2019 ($Million) 
Table 56 Canada: Market Size, By Type Of Cell, 2012–2019 ($Million) 
Table 57 Canada: Market Size, By End User, 2012–2019 ($Million) 
Table 58 Europe: Market Size, By Country, 2012–2019 ($Million) 
Table 59 Europe: Market Size, By Molecule Type, 2012–2019 ($Million) 
Table 60 Europe: Market Size, By Type Of Cell, 2012–2019 ($Million) 
Table 61 Europe: Market Size, By Technology, 2012–2019 ($Million) 
Table 62 Europe: Market Size, By End User, 2012–2019 ($Million) 
Table 63 Germany: Market Size, By Molecule Type, 2012–2019 ($Million) 
Table 64 Germany: Market Size, By Type Of Cell, 2012–2019 ($Million) 
Table 65 Germany: Market Size, By End User, 2012–2019 ($Million) 
Table 66 U.K.: Market Size, By Molecule Type, 2012–2019 ($Million) 
Table 67 U.K.: Market Size, By Type Of Cell, 2012–2019 ($Million) 
Table 68 U.K.: Market Size, By End User, 2012–2019 ($Million) 
Table 69 Roe: Market Size, By Molecule Type, 2012–2019 ($Million) 
Table 70 Roe: Market Size, By Type Of Cell, 2012–2019 ($Million) 
Table 71 Roe: Market Size, By End User, 2012–2019 ($Million) 
Table 72 Other Asia-Pacific Countries And Drivers For Market
Table 73 Apac: Market Size, By Molecule Type, 2012–2019 ($Million) 
Table 74 Apac: Market Size, By Type Of Cell, 2012–2019 ($Million) 
Table 75 Apac: Market Size, By Technology, 2012–2019 ($Million) 
Table 76 Apac: Market Size, By End User, 2012–2019 ($Million) 
Table 77 Row: Market Size, By Molecule Type, 2012–2019 ($Million) 
Table 78 Row: Market Size, By Type Of Cell, 2012–2019 ($Million) 
Table 79 Row: Market Size, By Technology, 2012–2019 ($Million) 
Table 80 Row: Market Size, By End User, 2012–2019 ($Million) 
Table 81 New Product Launches, 2011–2014
Table 82 Agreements & Partnerships, 2011–2014
Table 83 Acquisition, 2011–2014
Table 84 Expansion, 2011–2014
Table 85 Other Developments, 2011–2014 
  
List of Figures  (51 Figures)
 
Figure 1 Research Methodology
Figure 2 Market Size Estimation
Figure 3 Breakdown Of Primary Interviews: By Type, Company, Designation, And Region
Figure 4 Market Snapshot, By Type Of Cells (2014 Vs. 2019) 
Figure 5 SUB Market, By Molecule Type
Figure 6 SUB Market, By Technology
Figure 7 SUB Market, By End User
Figure 8 Geographical Snapshot, 2014
Figure 9 Growing Biologics Market And Improved Return On Investment Will Drive Market Growth
Figure 10 Monoclonal Antibodies Segment To Hold Largest Market Share
Figure 11 North America Continues To Hold Maximum Market Share Of SUB Market
Figure 12 Wave-Induced Motion Bioreactor Segment Continues To Lead Sub Technology Market
Figure 13 Biopharmaceutical Manufacturers End-User Segment To See Highest Growth Rate From 2014–2019
Figure 14 Asia-Pacific Market Holds Lucrative Growth Opportunities
Figure 15 Asia-Pacific Will Grow At Fastest Rate In 2014-2019
Figure 16 Evolution
Figure 17 Technological Advancements Play A Crucial Role In The SUB Market
Figure 18 Single Use Bioreactor Market, By Technology
Figure 19 Market, By Type Of Molecule
Figure 20 Market, By Type Of Cells
Figure 21 Market, By End User
Figure 22 Improved Returns On Investment Will Spur The Growth Of The SUB Market 
Figure 23 Supply Chain: Absence Of Guidelines Imposes Additional Burden On Sub Manufacturers
Figure 24 Porter’s Five Forces Analysis
Figure 25 Europe To Hold Largest Share Of Wave-Induced Motion Market In Forecast Period
Figure 26 Europe Continue To Lead The Stirred Tank Segment From 2014 To 2019
Figure 27 Europe To Dominate Single-Use Bubble Column Bioreactors Market In Forecast Period
Figure 28 North America To Account For Second-Largest Share Of The Other Technologies Segment In 2019
Figure 29 Monoclonal Antibodies Segment Dominates The Single-Use Bioreactors Market, By Molecule Type
Figure 30 Europe Will Dominate The Recombinant Proteins Market
Figure 31 Asia-Pacific Expected To Show Fastest Growth In Forecast Period
Figure 32 Europe Dominates Gene Therapy Market
Figure 33 Asia-Pacific To Show Highest Growth In Other Molecules Market
Figure 34 Mammalian Cell Segment To Dominate The Single-Use Bioreactors Market, By Type Of Cell
Figure 35 Europe Will Continue To Lead The Market For Mammalian Cells In The Forecast Period
Figure 36 Bacterial Cells Segment To Emerge As Revenue Pocket For Manufacturers Of SUB In Asia-Pacific
Figure 37 Europe: Single-Use Bioreactors Market For Other Cells, By Country, 2012-2019 ($Million)
Figure 38 Broad End-User Base Of SUB Market
Figure 39 R&D (Cros, Biopharmaceutical Manufacturers, And Research Institutes) Segment Dominates The SUB End-User Market
Figure 40 Europe Will Continue To Lead The Market
Figure 41 Europe Will Continue To Lead The Biopharmaceutical Manufacturers End-User Market
Figure 42 Geographic Snapshot (2014): High-Growth Markets Emerging As New Revenue Pockets
Figure 43 Asia-Pacific: Attractive Market For All Molecule Types For Single Use Bioreactor
Figure 44 North America Market Snapshot: Government Support And Funding To Drive Demand For Single Use Bioreactor
Figure 45 Europe Market Snapshot: U.K. Is The Major Segment In The European Single-Use Bioreactors Market
Figure 46 Apac Market Snapshot: Monoclonal Antibodies Segment To Account For Largest Share In Apac
Figure 47 Wave-Induced Motion Technology Segment To Witness The Highest Growth In Row
Figure 48 Product Innovation, And Agreements, Collaborations And Partnerships Were Key Strategies Adopted In Last Three Years
Figure 49 Global Single-Use Bioreactor Market Share, By Key Player, 2013
Figure 50 Battle For Market Share: New Product Launches And Agreements, Collaboration And Partnerships Were Key Strategies
Figure 51 Geographical Revenue Mix Of Top 5 Market Players

The single use bioreactors (SUBs) market is expected to grow at a double digit CAGR of 18.4% to reach $470.9 million by 2019 from $202.5 million in 2014. Major factors fueling the growth of this market are low requirements of capital investment for setting up the facility, reduced complexity of automation, and energy efficiency. However, regulatory concerns regarding the mixing process, contamination by leachables and extractable, and difficulties in meeting good manufacturing practices (GMP) standards are restricting the growth of the single use bioreactor market.

The single use bioreactor market is segmented on the basis of molecule type (monoclonal antibodies (MAbs), vaccines, gene therapy, recombinant proteins, stem cells, and others (growth factors, interferons, antisense, RNA interference)), type of cell (mammalian cell, bacterial cell, yeast cell and others (insect cell and plant cell)), technology (wave-induced motion SUBs, stirred SUBs, single-use bubble column bioreactors, and others (single-use reactors with vertically perforated discs and single-use hybrid reactors)), end users (R&D (CROs, biopharmaceutical manufacturers, and research institutes) and biopharmaceutical manufacturers), and region (North America, Europe, Asia-Pacific, RoW).

MAbs is the largest segment of the single use bioreactor market by molecule type. The high growth rate of this segment can be attributed to the growing demand for SUBs in small-scale manufacturing of MAbs as a result of low investment costs, low requirement of manpower, reduction in time-consuming changeover procedures.

The mammalian cells segment of the market by type of cell is the largest and fastest-growing segment, owing to successful employment of SUB for mammalian cell cultures for clinical and commercial drug manufacturing.

The R&D department of CROs, biopharmaceutical manufacturers, and research institutes is the major end-user segment of the single use bioreactor market.

The SUB market is dominated by Europe, followed by North America. However, the Asia-Pacific region is expected to grow at the highest CAGR during the forecast period.

Key players operating in the single use bioreactor market are Thermo Fischer Scientific, Inc. (U.S.), Sartorius AG (Germany), Merck KGaA (Germany), GE Healthcare (U.S.), and Pall Corporation (U.S.)

SUB Market Scenario, by Type of Cell, 2014

Single Use Bioreactor Market

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