Aptamers Market - Technology Trend Analysis By Applications - Therapeutics, Diagnostics, Biosensors, Drug Discovery, Biomarker Discovery, Research Applications with Market Landscape Analysis - Global Forecasts to 2018
Publishing Date: July 2013
Report Code: BT 2018
Aptamers is an emerging market, widely considered as a rival or substitute to antibodies in the scientific industry. It is poised to grow rapidly in various application areas, including therapeutics and diagnostics. The global aptamers market is valued at $287 million in 2013 and is expected to reach $2.1 billion by 2018.
Aptamers existed in parallel with antibodies for two decades, but its market potential was not utilized, even to a fraction of antibodies. However, the achievement of Macugen has given a boost to the aptamer field. The list of promising aptamers in the clinical trials pipeline estimates that these synthetic chemical antibodies will soon surpass monoclonal antibodies in therapeutics, diagnosis, and imaging. With technological merits over antibodies, the aptamers market is poised to grow at par with antibodies in the next 10-15 years.
Though there are just < 60 companies (biotech and pharmaceutical) working on aptamers, there are quite a number of research groups working on diverse applications of aptamers, particularly in studying key target molecules involved in cardiovascular diseases, infectious diseases, and against viral antigens. Hundreds of research articles have been published and a lot of patents granted and filed for this technology.
The aptamers market is analyzed both in terms of qualitative, i.e. technological and quantitative, i.e. revenue, perspectives. The technological analysis includes discussion on inherent characteristics and capabilities of aptamers over antibodies and the various applications where aptamers can find its place. The market revenue analysis includes market segmentation and the expected market position by 2018, with the projected growth rate.
The aptamers market is classified by geography, application segments and aptamer type. The application segments are further divided as therapeutics, diagnostics, biosensors, drug discovery, biomarker discovery, and research applications. The advantages of chemically modified aptamers and low production cost compared to antibodies aid the growth of the market. However, the reduced market acceptance compared to the antibodies and increased time consumption for screening using SELEX will hamper the growth of this market, to a certain extent. While aptamer technology has existed for over two decades, the challenges imposed on the development of aptamers for small molecules has resulted in very few novel aptamers that can bind to practical small molecular targets. Nevertheless, there are many opportunities for the innovative application of small molecule binding aptamers in biosensing, drug discovery, diagnostics and therapeutics.
Besides a discussion on the properties of aptamers in the technological analysis, the basics on nucleic acid aptamers, peptide aptamers and the SELEX method for their synthesis are also discussed. Research applications are specifically discussed regarding aptamers use in flow cytometry, reagents and assays, mass spectrometry and western blotting. In addition, a number of therapeutic targets that are validated by basic research have been displayed under the therapeutics application segment. The complete value chain of the aptamers market is schematically represented and the significance of each stakeholder has been briefed.
Apart from the technological and market analysis, the investor climate has been assessed by tracking the complete investor network and collecting data on funds/grants and investments made towards the aptamers. Insights on current and future technological investment trends have also been discussed.
The adoption and developmental potential of the aptamers technology market has been discussed on a geographic basis, i.e. North America, Europe, Asia-Pacific, and Rest of the world, by taking select countries that are poised to have a greater market value during the forecast period.
In brief, this research report provides:
- A detailed description of the global technology developments and evolving trends in the aptamers field with key prominence on research innovations, collaborative efforts, and investments for aptamers.
- A close view on the aptamer based drug development for treatment of specific diseases by providing details and status of current aptamer drugs in pipeline.
- An impact analysis of major drivers and restraints influencing the adoption and growth of the aptamers market during the period of 2013to 2018.
- Porters five forces analysis and SWOT analysis.
- Market size - global market forecast for 2013-2018, including demand side analysis and strategic recommendations for technology/product developers.
- Competitive landscape based on the analysis of key patents and research publications.
Scope of the Report
This research report categorizes the global aptamers market into geography, applications, and aptamer type. The applications market is further broken down by geography, with exhaustive revenue analysis for 2012 and 2013, as well as the forecast up to 2018.
Global Aptamers Market - By Application
- Drug discovery
- Biomarker discovery
- Research applications
Global Aptamers Market - By Aptamer Type
- Nucleic acid aptamers
- Peptide aptamers
Global Aptamers Market - By Geography
- North America
- Asia Pacific
- Rest of the World (RoW)
Table Of Content
1 Introduction (Slide No- 18)
1.1 Logical Assumptions In This Study Based On Reliable Sources
1.2 Key Take-Aways
1.3 Report Scope
1.4 Research Methodology
1.5 Key Data Points From Secondary And Primary Sources
2 Executive Summary (Slide No- 25)
3 Aptamers Technology Landscape Analysis (Slide No- 29)
3.1 Technology Overview
3.2 History & Milestones Of Aptamers
3.3 Aptamers Vs Antibodies
3.4 Aptamer Types
3.4.1 Nucleic Acid Aptamers
3.4.2 Peptide Aptamers
3.5 Aptamer Synthesis & Modifications
220.127.116.11 Different Targets Of Therapeutic Interest
3.6.4 Drug Discovery
3.6.5 Biomarker Discovery
3.6.6 Research Applications
18.104.22.168 Reagents & Assays
22.214.171.124 Flow Cytometry
126.96.36.199 Mass Spectrometry
188.8.131.52 Western Blotting
3.7 Technology Value Chain Analysis
3.8 Aptamers Technology Innovations And Products With Applications
4 Aptamers Market Landscape Analysis (Slide No- 56)
4.1 Aptamers Market Segmentation
4.2 Aptamers Technology - Global Impact
4.3 Market Forecast (2013 - 2018) Overview
4.4 Global Aptamers Market Revenue Forecast (2013-2018)
4.4.1 Global Aptamers Market Revenue By Geography
184.108.40.206 North America
220.127.116.11 Asia Pacific
18.104.22.168 Rest Of The World
4.4.2 Global Aptamers Market Share By Geography
22.214.171.124 North America
126.96.36.199 Asia Pacific
188.8.131.52 Rest Of The World
4.4.3 Global Aptamers Market Revenue By Application Segments
184.108.40.206 Global Aptamers Market Share By Segments
220.127.116.11 Therapeutic Aptamers Market By Region
18.104.22.168 Diagnostics Aptamers Market By Region
22.214.171.124 Biosensors Aptamers Market By Region
126.96.36.199 Drug Discovery Aptamers Market By Region
188.8.131.52 Aptamers Biomarker Discovery Market By Region
184.108.40.206 Aptamers Research Applications Market By Region
4.4.4 Global Aptamers Market Revenue By Aptamer Type
220.127.116.11 Nucleic Acid Aptamer Market By Region
18.104.22.168 Peptide Aptamer Market By Region
22.214.171.124 Nucleic Acid And Peptide Aptamers Market Share By Region
4.5 Market Dynamics
4.5.1 Drivers - Explanation
126.96.36.199 Impact Analysis By Timeline
4.5.2 Restraints Explanation
188.8.131.52 Impact Analysis By Timeline
4.6 SWOT Analysis
4.7 Porters Five Forces Analysis
5 Technology Investment Potential (Slide No- 92)
5.1 Investment Climate Assessment
5.2 Investor Network
5.3 Some Funds And Investments On Aptamers
5.4 Some Funds And Investments From Nih By Fiscal Year
5.5 Some Funds And Investments From Nih By Its Associated Institutes/Centers (FY 2008-2013)
5.6 Insights On Current And Future Tech-Investment Trends
6 Aptamers Technology Adoption And Development Potential (Slide No- 104)
6.1 Geographic Adoption And Development Potential - Overview
6.2 North America
6.5 Row Selected Countries
6.6 Demand Side Analysis
6.7 Technology Roadmap
7 Aptamers Competitive Landscape (Slide No- 114)
7.1 Competitive Landscape Analysis
7.2 Key Acquisitions/Partnerships/Agreements/Collaborations (2009 2013)
7.3 Startups And Spinoffs Based On Aptamers Technology
7.4 Clinical Trials Of Aptamers By Different Properties (Anti-Coagulant Aptamers, Anti-Angiogenic Aptamers, Anti-Oncogenic Aptamers, Anti-Diabetic Aptamers)
7.4.1 Apamer Based Drugs In Clinical Trials
8 Intellectual Property And Research Strength Analysis (Slide No- 122)
8.1 Selected Aptamer And Selex Patents
8.2 IP Strength Analysis Of Aptamers
8.3 Proprietary Technologies Based On Aptamers
9 Analyst Insights And Recommendations (Slide No- 130)
9.1 Analyst Insights
9.2 Strategic Recommendations For Technology & Business Investors
9.3 Open Opportunity Invitations In The Field For Business Development
10 Company Profiles (Slide No- 134)
10.1 AM Biotechnologies, Llc
10.2 Aptagen, LIC
10.3 Aptamer Sciences Inc.
10.4 Aptamer Solutions Ltd
10.5 Aptares AG
10.6 Base Pair Biotechnologies
10.7 Integrated Dna Technologies, Inc
10.8 Neoventures Biotechnology Inc.
10.9 NOXXON Pharma AG
10.10 OTC Biotech
10.11 Somalogic, Inc.
10.12 Trilink Biotechnologies, Inc.
10.15 Aptamatrix, Inc.
10.17 Bioapter S.L.
10.18 Cd Genomics
10.19 Lucerna, Inc.
10.20 Ophthotech Corporation
10.21 Regado Biosciences, Inc.
List Of Table ( 14 Tables)
Tab - 1 Global Aptamers Market, 2013 - 2018 ($Million)
Tab - 2 Global Aptamers Market, By Geography, 2013 - 2018 ($Million)
Tab - 3 Global Aptamers Market Revenue, By Application Segment, 2013 - 2018 ($Million)
Tab - 4 Therapeutic Aptamers Market, By Geography, 2013 - 2018 ($Million)
Tab - 5 Diagnostics Aptamers Market, By Region, 2013 - 2018 ($Million)
Tab - 6 Biosensor Aptamers Market, By Geography, 2013 - 2018 ($Million)
Tab - 7 Drug Discovery Aptamers Market, By Geography, 2013 - 2018 ($Million)
Tab - 8 Aptamers Biomarker Discovery Market, By Geography, 2013 - 2018 ($Million)
Tab - 9 Aptamers Research Applications Market, By Geography, 2013 - 2018 ($Million)
Tab - 10 Global Aptamers Market, By Type, 2013 - 2018 ($Million)
Tab - 11 Nucleic Acid Aptamers Market, By Geography, 2013 - 2018 ($Million)
Tab - 12 Peptide Aptamers Market, By Geography, 2013 - 2018 ($Million)
Tab - 13 Funds By Nih & Associated Centers 2008-2013 ($Million)
Tab - 14 Projects And Funds By Nih & Associated Centers 2008-2013 ($Million)
List Of Figure (29 Figures)
Fig - 1 Global Market Of Aptamers 2013 2018 ($Million)
Fig - 2 Global Market Of Aptamers 2013 2018 ($Million)
Fig - 3 Global Aptamers Market Revenue, By Geography, 2013 2018 ($Million)
Fig - 4 Global Aptamers Market Share By Geography, 2013
Fig - 5 Global Aptamers Market Share By Geography, 2018
Fig - 6 Global Aptamers Technology Market Revenue, By Applications, 2013 2018 ($Million)
Fig - 7 Global Aptamers Technology Market Share, By Applications, 2013 2018
Fig - 8 Global Aptamers Market Share By Segments, 2013
Fig - 9 Global Aptamers Market Share By Segments, 2018
Fig - 10 Therapeutic Aptamers Market, By Region, 2013 2018 ($Million)
Fig - 11 Therapeutic Aptamer Market By Region, 2013
Fig - 12 Therapeutic Aptamer Market By Region, 2018
Fig - 13 Diagnostics Aptamers Market, By Region, 2013 2018 ($Million)
Fig - 14 Diagnostics Aptamers Market By Region, 2013
Fig - 15 Diagnostics Aptamers Market By Region, 2018
Fig - 16 Biosensor Aptamers Market, By Region, 2013 2018 ($Million)
Fig - 17 Biosensor Aptamers Market By Region, 2013
Fig - 18 Biosensor Aptamers Market By Region, 2018
Fig - 19 Drug Discovery Aptamers Market, By Region, 2013 2018 ($Million)
Fig - 20 Drug Discovery Aptamers Market By Region, 2013 80
Fig - 21 Drug Discovery Aptamers Market By Region, 2018 80
Fig - 22 Aptamers Biomarker Discovery Market, By Region, 2013 2018 ($Million)
Fig - 23 Aptamers Biomarker Discovery Market By Region, 2013
Fig - 24 Aptamers Biomarker Discovery Market By Region, 2018
Fig - 25 Aptamers Research Applications Market, By Region, 2013 2018 ($Million)
Fig - 26 Aptamers Research Applications Market By Region, 2013
Fig - 27 Aptamers Research Applications Market By Region, 2018
Fig - 28 Global Aptamers Market, Nucleic Acid Aptamer, 2013 2018 ($Million)
Fig 29 Global Aptamers Market, Peptide Aptamer, 2013 2018 ($Million)
The global aptamers market is anticipated to reach $2.1 billion by 2018 growing at a CAGR of 49.24%. The aptamers market is divided by geography (North America, Europe, Asia-Pacific and Rest of the World), application segments (therapeutics, diagnostics, biosensors, drug discovery, biomarker discovery, and research applications) and aptamer type (Nucleic acid aptamers and Peptide aptamers). Further each application segment and the aptamer type is broken down by geography, with exhaustive revenue analysis for the entire forecast period. Of the above mentioned application segments, research applications is the largest revenue segment; however, biomarker discovery and diagnostics will be the fastest-growing segment.
The potential growth of the market is attributed to future diagnostics, drug discovery and research applications. The future approval of a few diagnostic tests specifically for infectious diseases and a couple of drugs in the market will greatly propel the market. The global market for aptamers is expected to grow, backed by technological advancements with respect to selection processes and synthesis. The market will experience continuous improvements in aptamer synthesis and its applicability in drug discovery and routine research.The market is witnessing a trend toward development of personalized medicine and point-of-care diagnostic tests. Additionally, the demand for safe and cost-effective drugs for treatment of cancer (which can be fulfilled by aptamer therapeutics), will remarkably fuel market growth.
North America is a significant contributor to the market, followed by Europe, due to the presence of technology providers and better R&D facilities. The new markets that are expected to grow at a brisk pace are emerging economics such as China, India, Japan and other regions of Asia-Pacific and untapped markets of Europe due to their growing GDP, healthcare costs, and rising demand for safe and cost-effective diagnostics and therapeutics.
Key players in this market are AM Biotechnologies, LLC (U.S.), Aptagen, LLC (U.S.), Aptamer Sciences Inc. (South Korea), Aptamer Solutions Ltd (U.K.), Base Pair Biotechnologies (U.S.), Bioapter S.L. (Spain), Integrated Biotechnologies, Inc. (U.S.), NOXXON Pharma AG (Germany), OTC Biotech (U.S.), Regado Biosciences, Inc. (U.S.), Somalogic, Inc. (U.S.), and TriLink BioTechnologies, Inc. (U.S.).
Source: Expert Interviews, Annual Reports, Secondary Research Data, MarketsandMarkets Analysis.