Cartilage Repair/ Cartilage Regeneration Market

Cartilage Repair/ Cartilage Regeneration Market by Treatment modalities (Cell based Type (Chondrocyte Transplantation, Growth Factor), Non-Cell (Tissue Scaffolds)), Application (Hyaline), End User (ASCs, Clinic), Site (Knee) - Global Forecast to 2025

Report Code: BT 4781 Oct, 2020, by marketsandmarkets.com

[157 Pages Report] The global cartilage repair and regeneration market is projected to reach USD 1,603 million by 2025 from USD 787 million in 2020, at a CAGR of 15.3% during the forecast period. The growth of this market is primarily driven by the increasing incidence of osteoarthritis and increasing funding and investments for research in this field.

Cartilage Regeneration Market

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COVID-19 impact on the cartilage repair and regeneration global market

The COVID-19 outbreak will impact the cartilage repair and regeneration market in the initial phase of the forecast period. Due to nationwide lockdowns, denied wound care services, and canceled or postponed elective surgeries, the cartilage repair and regeneration market is expected to decline during the initial phase of the forecasted period. However, during the latter half of the forecast period, the demand for cartilage repair and regeneration products is expected to rise drastically.

Elective surgeries are being denied (canceled/postponed) to reserve or redirect the available limited capacities and resources (like hospital beds and patient care professionals) towards COVID-19 patient care. Moreover, various countries have enforced lockdowns and curfews to curb the rising number of positive COVID-19 cases. Due to these lockdowns, patients are not able to visit hospitals, OPDs, or clinics. This temporary denial of wound care services, cancer care surgeries/therapies, and other healthcare services are expected to limit the growth of the cartilage repair and regeneration market during the initial phase of the forecasted period; however, this demand is expected to rise exponentially in the latter half of the forecasted period. Due to lockdowns in Q1 and Q2 of 2020, the number of elective surgeries performed significantly reduced. This has significantly reduced the sales of cartilage repair and regeneration products in Q1 and Q2 of 2020. On average, the growth rate declined by 20−30% in the last six months.

Cartilage Repair and Regeneration Market Dynamics

Driver: Increasing incidence of osteoarthritis

Over the years, the incidence of osteoarthritis has increased across the globe. According to a study by the University of North Carolina, around 1 million knee and hip replacement procedures are conducted every year in the US. The economic burden of osteoarthritis in the US is ~136.8 billion annually. As per the Arthritis Foundation in 2019, degenerative joint diseases such as osteoarthritis will affect more than 130 million patients worldwide by 2050.

Some of the most commonly used treatments for osteoarthritis are autologous chondrocyte implantation and Scaffolds implants Thus, the increasing incidence of osteoarthritis is expected to drive the demand for cartilage repair and regeneration products.

Restraint: High cost of cartilage repair surgeries

Although cartilage repair surgeries offer better and long-lasting results as compared to total knee replacement surgeries, the cost of these therapies is one of the major factors limiting their adoption among patients. The average cost for knee replacement procedures is around USD 16,000, while the average cost of cartilage repair procedures is around USD 18,000–USD 23,000, depending on the region where the procedure is being performed. Such high costs underrate the results of cartilage repair therapies, and in turn, result in a lower preference for these procedures as compared to knee replacement surgeries.

Opportunity: Technological advancements

As a result of the rising government investments in regenerative medicine for cartilage regeneration research, the number of companies focusing on the development of cartilage regeneration products has increased significantly over the last few years. As a result of these factors, the number of clinical trials and the development of new technologies for cartilage regeneration has increased. Major players in this market are making significant investments in R&D, resulting in a strong pipeline of products based on various approaches to cartilage repair.

Challenge: Limitation of cartilage-based stem cell products

Active research is ongoing to identify an exhaustive universal source of progenitor cells, such as embryonic stem cells and induced pluripotent stem cells, for cartilage repair and regeneration. However, there are major challenges associated with their clinical use due to ethical considerations and safety issues, such as immune rejection, tumorigenesis, and teratoma formation. In order to monitor these activities, strict regulations have been formulated by authorities such as the Human Tissue Authority (HTA), Human Fertilization and Embryology Authority (HFEA), Medicines and Healthcare Products Regulatory Agency (MHRA), and the Central Ethics Committee for Stem Cell Research. Due to the presence of these organizations, coupled with the ethical concerns on the use of embryonic stem cells in research and development activities, regenerative medicine research is being restricted to a great extent in various countries across the globe. Other issues related to the effective use of stem cells include reduced potentiality with age and disease and production of fibrocartilage instead of hyaline cartilage at the site of damage. With stringent regulations in place, a large number of products under development do not proceed to the marketing approval stage as they cannot clear the safety and efficacy requirements.

By end user segment, the hospitals segment accounted for the largest share of the cartilage repair and regeneration market in 2019.

Based on end users, the cartilage repair and regeneration market is segmented into hospitals and ambulatory surgery centers (ASCs) and clinics. The hospitals segment accounted for the largest share of the cartilage repair and regeneration market in 2019. This can be attributed to the large number of minimally invasive surgeries performed in hospitals and the growing number of hospitals in emerging economies.

By application site, the knee segment accounted for the largest share of the cartilage repair and regeneration market in 2019.

Based on the application site, the cartilage repair and regeneration market is segmented into knee, hip, ankle and foot, and other application sites (nose and shoulder). The knee segment accounted for the largest share of application site segment of the global cartilage repair and regeneration market in 2019. This can be attributed to the growing number of knee arthroscopy procedures and the increasing incidence of knee osteoarthritis.

North America accounted for the largest share of the cartilage repair and regeneration market in 2019.

In 2019, North America accounted for the largest share of the global market, followed by Europe. The large share of the North American region can be attributed to the high burden of osteoarthritis, increasing prevalence of sports injuries, and increasing research investments in the US and Canada.

Cartilage Regeneration Market by Region

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The cartilage repair and regeneration market is dominated by a few globally established players such as Smith & Nephew plc (UK), DePuy Synthes (US), Zimmer Biomet (US), CONMED Corporation (US), Stryker Corporation (US), and Vericel Corporation (US).

Scope of the report

Report Metric

Details

Market Size Available for Years

2018–2025

Base Year Considered

2019

Forecast Period

2020–2025

Forecast Units

Value (USD)

Segments Covered

Application, Treatment Modality, Application Site, End user, and Region

Geographies Covered

North America, Europe, APAC and the RoW

Companies Covered

The major market players include DePuy Synthes (US), Smith & Nephew plc (UK), Zimmer Biomet (US), CONMED Corporation (US), Stryker Corporation (US), and Vericel Corporation (US). (Total 16 companies)

 

The study categorizes the cartilage repair and regeneration market market into the following segments and subsegments:

Cartilage Repair and Regeneration Market, by Treatment Modality

  • Cell-based
    • Chondrocyte Transplantation
    • Stem Cells
    • Growth Factors
  • Non-cell-based
    • Tissue Scaffolds
    • Cell-free Composites

Cartilage Repair and Regeneration Market, by Application

  • Hyaline Cartilage
  • Fibrocartilage

Cartilage Repair and Regeneration Market, by Application Site

  • Knee
  • Hip
  • Ankle and Foot
  • Other Application Sites

Cartilage Repair and Regeneration Market, by End User

  • Hospitals
  • Ambulatory Surgery Centers and Clinics

Cartilage Repair and Regeneration Market, by Region

  • North America
    • US
    • Canada
  • Europe
    • Germany
    • France
    • UK
    • Rest of Europe
  • Asia Pacific
    • Japan
    • China
    • India
    • Rest of Asia Pacific
  • Rest of the World

Recent Developments

  • In 2019, Smith & Nephew acquired Osiris Therapeutics, Inc. (US). This acquisition increased the company’s customer base and enhanced the advanced wound care management segment of Smith & Nephew.
  • In 2019, MEDIPOST (South Korea) expanded the GMP manufacturing facility to accelerate CARTISTEM production.
  • In 2018, Vericel Corporation collaborated with Innovative Cellular Therapeutics (ICT, China), under this collaboration, ICT will develop and distribute MACI, Epicel, Ixmyelocel-T, and Carticel products in China, South Korea, Singapore, and other countries in Asia.

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TABLE OF CONTENTS

1 INTRODUCTION (Page No. - 26)
    1.1 OBJECTIVES OF THE STUDY
    1.2 MARKET DEFINITION
        TABLE 1 INCLUSIONS & EXCLUSIONS
    1.3 MARKET SCOPE
        FIGURE 1 MARKETS COVERED
           1.3.1 YEARS CONSIDERED FOR THE STUDY
    1.4 CURRENCY
    1.5 LIMITATIONS
    1.6 STAKEHOLDERS
    1.7 SUMMARY OF CHANGES

2 RESEARCH METHODOLOGY (Page No. - 30)
    2.1 RESEARCH DATA
           2.1.1 SECONDARY DATA
           2.1.2 PRIMARY DATA
                 FIGURE 2 BREAKDOWN OF PRIMARIES: CARTILAGE REPAIR AND REGENERATION MARKET
           2.1.3 MARKET DATA ESTIMATION & TRIANGULATION
                    2.1.3.1 Data Triangulation
                            FIGURE 3 DATA TRIANGULATION METHODOLOGY
    2.2 MARKET ESTIMATION METHODOLOGY
        FIGURE 4 MARKET SIZE ESTIMATION APPROACH 1: COMPANY REVENUE ANALYSIS-BASED ESTIMATION
        FIGURE 5 MARKET SIZE ESTIMATION APPROACH 2: TOP-DOWN APPROACH
        FIGURE 6 CARTILAGE REPAIR AND REGENERATION MARKET SIZE (USD MILLION)
    2.3 GROWTH RATE ASSUMPTIONS/GROWTH FORECAST
        FIGURE 7 SEGMENTAL GROWTH RATE OF COMPANIES (2015−2019)
        FIGURE 8 FINAL CAGR PROJECTIONS (2020−2025)
        FIGURE 9 CAGR PROJECTIONS FROM THE ANALYSIS OF DEMAND-SIDE DRIVERS AND OPPORTUNITIES
    2.4 INSIGHTS FROM PRIMARIES
        FIGURE 10 MARKET VALIDATION FROM PRIMARY EXPERTS
    2.5 RESEARCH ASSUMPTIONS
    2.6 RISK ASSESSMENT
        TABLE 2 RISK ASSESSMENT

3 EXECUTIVE SUMMARY (Page No. - 39)
  FIGURE 11 CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY
  FIGURE 12 CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2020—2025
  FIGURE 13 CARTILAGE REPAIR AND REGENERATION MARKET SHARE, BY END USER, 2019
  FIGURE 14 GEOGRAPHICAL SNAPSHOT OF THE CARTILAGE REPAIR AND REGENERATION MARKET

4 PREMIUM INSIGHTS (Page No. - 42)
    4.1 CARTILAGE REPAIR AND REGENERATION MARKET OVERVIEW
        FIGURE 15 RISING INCIDENCE OF OSTEOARTHRITIS TO DRIVE MARKET GROWTH
    4.2 ASIA PACIFIC: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY AND COUNTRY (2019)
        FIGURE 16 CELL-BASED SEGMENT ACCOUNTED FOR THE LARGEST SHARE OF THE ASIA PACIFIC MARKET IN 2019
    4.3 CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE (2020–2025)
        FIGURE 17 CHONDROCYTE TRANSPLANTATION SEGMENT WILL CONTINUE TO DOMINATE THE MARKET IN THE FORECAST PERIOD
    4.4 CARTILAGE REPAIR AND REGENERATION MARKET SHARE, BY APPLICATION, 2020 VS. 2025
        FIGURE 18 HYALINE CARTILAGE IS THE LARGEST APPLICATION SEGMENT OF THE CARTILAGE REPAIR AND REGENERATION MARKET
    4.5 CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2020 VS. 2025 (USD MILLION)
        FIGURE 19 THE KNEE SEGMENT WILL CONTINUE TO DOMINATE THE CARTILAGE REPAIR AND REGENERATION MARKET IN 2025

5 MARKET OVERVIEW (Page No. - 46)
    5.1 INTRODUCTION
    5.2 MARKET DYNAMICS
        FIGURE 20 CARTILAGE REPAIR AND REGENERATION MARKET: DRIVERS, RESTRAINTS, OPPORTUNITIES, AND CHALLENGES
           5.2.1 MARKET DRIVERS
                    5.2.1.1 Increasing incidence of osteoarthritis
                    5.2.1.2 Increasing research funding and investments
           5.2.2 RESTRAINTS
                    5.2.2.1 High cost of cartilage repair surgeries
           5.2.3 OPPORTUNITIES
                    5.2.3.1 Technological advancements
           5.2.4 CHALLENGES
                    5.2.4.1 Limitation of cartilage-based stem cell products
    5.3 SUPPLY CHAIN ANALYSIS
        FIGURE 21 SUPPLY CHAIN ANALYSIS OF THE CARTILAGE REPAIR AND REGENERATION MARKET
    5.4 IMPACT OF THE COVID-19 OUTBREAK ON THE GROWTH OF THE CARTILAGE REPAIR AND REGENERATION MARKET
        FIGURE 22 COVID-19 IMPACT ON THE CARTILAGE REPAIR AND REGENERATION MARKET
    5.5 REGULATORY ASSESSMENT
           5.5.1 INTRODUCTION
           5.5.2 NORTH AMERICA
           5.5.3 EUROPE
           5.5.4 ASIA PACIFIC
    5.6 PATENT ANALYSIS
           5.6.1 DOCUMENT TYPE
                 TABLE 3 PATENTS FILED
                 FIGURE 23 PATENTS FILED (2016—2020)
                 FIGURE 24 PATENTS FILED BETWEEN 2016 AND AUGUST 2020
           5.6.2 INSIGHTS
                 FIGURE 25 JURISDICTION ANALYSIS (2019)
           5.6.3 TOP APPLICANTS (2019)
    5.7 PIPELINE ANALYSIS
           5.7.1 BASED ON THE PHASE OF CLINICAL TRIAL
                 FIGURE 26 MAJORITY OF CARTILAGE REPAIR CANDIDATE PRODUCTS ARE IN PHASE 3
    5.8 TECHNOLOGY ANALYSIS

6 CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY (Page No. - 59)
    6.1 INTRODUCTION
        TABLE 4 CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
    6.2 CELL-BASED
        TABLE 5 CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
        TABLE 6 CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY REGION, 2018–2025 (USD MILLION)
        TABLE 7 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY COUNTRY, 2018–2025 (USD MILLION)
        TABLE 8 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY COUNTRY, 2018–2025 (USD MILLION)
        TABLE 9 APAC: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY COUNTRY, 2018–2025 (USD MILLION)
           6.2.1 CHONDROCYTE TRANSPLANTATION
                    6.2.1.1 Cost-effectiveness of chondrocyte transplantation to support market growth
                            TABLE 10 CHONDROCYTE TRANSPLANTATION MARKET, BY REGION, 2018–2025 (USD MILLION)
                            TABLE 11 NORTH AMERICA: CHONDROCYTE TRANSPLANTATION MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
           6.2.2 GROWTH FACTORS
                    6.2.2.1 Promising results associated with growth factors is the major factor driving the growth of this segment
                            TABLE 12 GROWTH FACTORS MARKET, BY REGION, 2018–2025 (USD MILLION)
                            TABLE 13 NORTH AMERICA: GROWTH FACTORS MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
           6.2.3 STEM CELLS
                    6.2.3.1 Advancements in stem cell-based tissue engineering will drive the growth of this segment
                            TABLE 14 STEM CELLS MARKET, BY REGION, 2018–2025 (USD MILLION)
                            TABLE 15 NORTH AMERICA: STEM CELLS MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
    6.3 NON-CELL-BASED
        TABLE 16 CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
        TABLE 17 CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY REGION, 2018–2025 (USD MILLION)
        TABLE 18 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY COUNTRY, 2018–2025 (USD MILLION)
        TABLE 19 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY COUNTRY, 2018–2025 (USD MILLION)
        TABLE 20 APAC: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY COUNTRY, 2018–2025 (USD MILLION)
           6.3.1 TISSUE SCAFFOLDS
                    6.3.1.1 Benefits of the one-step procedure likely to boost the market growth
                            TABLE 21 TISSUE SCAFFOLDS MARKET, BY REGION, 2018–2025 (USD MILLION)
           6.3.2 CELL-FREE COMPOSITES
                    6.3.2.1 Increasing research to support market growth
                            TABLE 22 CELL-FREE COMPOSITES MARKET, BY REGION, 2018–2025 (USD MILLION)

7 CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE (Page No. - 68)
    7.1 INTRODUCTION
        TABLE 23 CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
    7.2 KNEE
           7.2.1 INCREASING CASES OF KNEE ARTHROSCOPY TO DRIVE MARKET GROWTH
                 TABLE 24 CARTILAGE REPAIR AND REGENERATION MARKET FOR KNEE, BY REGION, 2018–2025 (USD MILLION)
                 TABLE 25 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET FOR KNEE, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 26 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET FOR KNEE, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 27 APAC: CARTILAGE REPAIR AND REGENERATION MARKET FOR KNEE, BY COUNTRY, 2018–2025 (USD MILLION)
    7.3 HIP
           7.3.1 INCREASING ADOPTION OF MINIMALLY INVASIVE ARTHROSCOPY PROCEDURES TO SUPPORT MARKET GROWTH
                 TABLE 28 CARTILAGE REPAIR AND REGENERATION MARKET FOR HIP, BY REGION, 2018–2025 (USD MILLION)
                 TABLE 29 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET FOR HIP, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 30 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET FOR HIP, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 31 APAC: CARTILAGE REPAIR AND REGENERATION MARKET FOR HIP, BY COUNTRY, 2018–2025 (USD MILLION)
    7.4 ANKLE & FOOT
           7.4.1 INCREASING SPORTS INJURIES IN THE ANKLE & FOOT ARE LIKELY TO DRIVE THE DEMAND FOR CARTILAGE REPAIR PROCEDURES
                 TABLE 32 CARTILAGE REPAIR AND REGENERATION MARKET FOR ANKLE & FOOT, BY REGION, 2018–2025 (USD MILLION)
                 TABLE 33 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET FOR ANKLE & FOOT, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 34 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET FOR ANKLE & FOOT, BY COUNTRY, 2018–2025 (USD MILLION)
    7.5 OTHER APPLICATION SITES
        TABLE 35 CARTILAGE REPAIR AND REGENERATION MARKET FOR OTHER APPLICATION SITES, BY REGION, 2018–2025 (USD MILLION)
        TABLE 36 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET FOR OTHER APPLICATION SITES, BY COUNTRY, 2018–2025 (USD MILLION)

8 CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION (Page No. - 75)
    8.1 INTRODUCTION
        TABLE 37 CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
    8.2 HYALINE CARTILAGE
           8.2.1 HYALINE CARTILAGE SEGMENT HOLDS THE LARGER MARKET SHARE
                 TABLE 38 HYALINE CARTILAGE REPAIR AND REGENERATION MARKET, BY REGION, 2018–2025 (USD MILLION)
                 TABLE 39 NORTH AMERICA: HYALINE CARTILAGE REPAIR AND REGENERATION MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 40 EUROPE: HYALINE CARTILAGE REPAIR AND REGENERATION MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 41 APAC: HYALINE CARTILAGE REPAIR AND REGENERATION MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
    8.3 FIBROCARTILAGE
           8.3.1 FIBROCARTILAGE PROVIDES SUPPORT AND RIGIDITY TO SURROUNDING STRUCTURES
                 TABLE 42 FIBROCARTILAGE REPAIR AND REGENERATION MARKET, BY REGION, 2018–2025 (USD MILLION)
                 TABLE 43 NORTH AMERICA: FIBROCARTILAGE REPAIR AND REGENERATION MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 44 EUROPE: FIBROCARTILAGE REPAIR AND REGENERATION MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 45 APAC: FIBROCARTILAGE REPAIR AND REGENERATION MARKET, BY COUNTRY, 2018–2025 (USD MILLION)

9 CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER (Page No. - 80)
    9.1 INTRODUCTION
        TABLE 46 CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
    9.2 HOSPITALS
           9.2.1 HOSPITALS ARE THE LARGEST & FASTEST-GROWING END USERS OF THE MARKET
                 TABLE 47 CARTILAGE REPAIR AND REGENERATION MARKET FOR HOSPITALS, BY REGION, 2018–2025 (USD MILLION)
                 TABLE 48 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET FOR HOSPITALS, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 49 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET FOR HOSPITALS, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 50 APAC: CARTILAGE REPAIR AND REGENERATION MARKET FOR HOSPITALS, BY COUNTRY, 2018–2025 (USD MILLION)
    9.3 AMBULATORY SURGERY CENTERS & CLINICS
           9.3.1 RISING PREFERENCE FOR PERFORMING SURGERIES IN ASCS IS SUPPORTING THE GROWTH OF THIS SEGMENT
                 TABLE 51 CARTILAGE REPAIR AND REGENERATION MARKET FOR ASCS & CLINICS, BY REGION, 2018–2025 (USD MILLION)
                 TABLE 52 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET FOR ASCS & CLINICS, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 53 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET FOR ASCS & CLINICS, BY COUNTRY, 2018–2025 (USD MILLION)
                 TABLE 54 APAC: CARTILAGE REPAIR AND REGENERATION MARKET FOR ASCS & CLINICS, BY COUNTRY, 2018–2025 (USD MILLION)

10 CARTILAGE REPAIR AND REGENERATION MARKET, BY REGION (Page No. - 85)
     10.1 INTRODUCTION
          FIGURE 27 CARTILAGE REPAIR AND REGENERATION MARKET, BY REGION, 2020 VS. 2025 (USD MILLION)
          TABLE 55 CARTILAGE REPAIR AND REGENERATION MARKET, BY REGION, 2018–2025 (USD MILLION)
     10.2 NORTH AMERICA
          FIGURE 28 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET SNAPSHOT
          TABLE 56 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
          TABLE 57 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
          TABLE 58 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
          TABLE 59 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
          TABLE 60 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
          TABLE 61 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
          TABLE 62 NORTH AMERICA: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025(USD MILLION)
             10.2.1 US
                        10.2.1.1 Increasing incidence of obesity is the major factor supporting the market growth in the US
                                 TABLE 63 US: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
                                 TABLE 64 US: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 65 US: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 66 US: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
                                 TABLE 67 US: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
                                 TABLE 68 US: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
             10.2.2 CANADA
                        10.2.2.1 Increasing investments in regenerative medicine research to drive market growth
                                 TABLE 69 CANADA: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
                                 TABLE 70 CANADA: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 71 CANADA: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 72 CANADA: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
                                 TABLE 73 CANADA: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
                                 TABLE 74 CANADA: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
     10.3 EUROPE
          TABLE 75 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
          TABLE 76 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
          TABLE 77 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
          TABLE 78 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
          TABLE 79 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
          TABLE 80 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
          TABLE 81 EUROPE: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
             10.3.1 GERMANY
                        10.3.1.1 Strong R&D base and focus on minimally invasive surgeries to support market growth
                                 TABLE 82 GERMANY: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
                                 TABLE 83 GERMANY: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 84 GERMANY: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 85 GERMANY: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
                                 TABLE 86 GERMANY: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
                                 TABLE 87 GERMANY: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
             10.3.2 UK
                        10.3.2.1 Rising number of clinical trials in the UK to drive market growth
                                 TABLE 88 UK: CARTILAGE REPAIR AND REGENERATION PRODUCTS UNDER CLINICAL TRIALS
                                 TABLE 89 UK: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
                                 TABLE 90 UK: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 91 UK: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 92 UK: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
                                 TABLE 93 UK: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
                                 TABLE 94 UK: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
             10.3.3 FRANCE
                        10.3.3.1 Rising healthcare expenditure in the country to drive market growth
                                 TABLE 95 FRANCE: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
                                 TABLE 96 FRANCE: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 97 FRANCE: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 98 FRANCE: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
                                 TABLE 99 FRANCE: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
                                 TABLE 100 FRANCE: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
             10.3.4 REST OF EUROPE
                    TABLE 101 ROE: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
                    TABLE 102 ROE: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                    TABLE 103 ROE: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                    TABLE 104 ROE: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
                    TABLE 105 ROE: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
                    TABLE 106 ROE: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
     10.4 ASIA PACIFIC
          FIGURE 29 ASIA PACIFIC: CARTILAGE REPAIR AND REGENERATION MARKET
          TABLE 107 APAC: CARTILAGE REPAIR AND REGENERATION MARKET, BY COUNTRY, 2018–2025 (USD MILLION)
          TABLE 108 APAC: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
          TABLE 109 APAC: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
          TABLE 110 APAC: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
          TABLE 111 APAC: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
          TABLE 112 APAC: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
          TABLE 113 APAC: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
             10.4.1 JAPAN
                        10.4.1.1 Rising geriatric population is the major factor supporting market growth in Japan
                                 TABLE 114 JAPAN: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
                                 TABLE 115 JAPAN: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 116 JAPAN: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 117 JAPAN: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
                                 TABLE 118 JAPAN: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
                                 TABLE 119 JAPAN: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
             10.4.2 CHINA
                        10.4.2.1 China forms the fastest-growing market in the APAC
                                 TABLE 120 CHINA: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
                                 TABLE 121 CHINA: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 122 CHINA: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 123 CHINA: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
                                 TABLE 124 CHINA: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
                                 TABLE 125 CHINA: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
             10.4.3 INDIA
                        10.4.3.1 Medical tourism will propel market growth in India
                                 TABLE 126 INDIA: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
                                 TABLE 127 INDIA: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 128 INDIA: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                                 TABLE 129 INDIA: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
                                 TABLE 130 INDIA: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
                                 TABLE 131 INDIA: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
             10.4.4 REST OF ASIA PACIFIC
                    TABLE 132 ROAPAC: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
                    TABLE 133 ROAPAC: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                    TABLE 134 ROAPAC: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
                    TABLE 135 ROAPAC: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
                    TABLE 136 ROAPAC: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
                    TABLE 137 ROAPAC: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)
     10.5 REST OF THE WORLD
          TABLE 138 ROW: CARTILAGE REPAIR AND REGENERATION MARKET, BY TREATMENT MODALITY, 2018–2025 (USD MILLION)
          TABLE 139 ROW: CARTILAGE REPAIR AND REGENERATION MARKET FOR CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
          TABLE 140 ROW: CARTILAGE REPAIR AND REGENERATION MARKET FOR NON-CELL-BASED APPROACHES, BY TYPE, 2018–2025 (USD MILLION)
          TABLE 141 ROW: CARTILAGE REPAIR AND REGENERATION MARKET, BY END USER, 2018–2025 (USD MILLION)
          TABLE 142 ROW: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION, 2018–2025 (USD MILLION)
          TABLE 143 ROW: CARTILAGE REPAIR AND REGENERATION MARKET, BY APPLICATION SITE, 2018–2025 (USD MILLION)

11 COMPETITIVE LANDSCAPE (Page No. - 122)
     11.1 INTRODUCTION
     11.2 MARKET RANKING ANALYSIS
          FIGURE 30 CARTILAGE REPAIR AND REGENERATION MARKET RANKING, 2019
             11.2.1 MARKET REVENUE ANALYSIS (2015–2019)
                    FIGURE 31 REVENUE ANALYSIS OF MAJOR PLAYERS (2015−2019)
     11.3 MARKET EVALUATION FRAMEWORK
          TABLE 144 MARKET EVALUATION FRAMEWORK: PRODUCT LAUNCH—THE MAJOR STRATEGY ADOPTED BY PLAYERS
     11.4 COMPETITIVE SCENARIO
             11.4.1 KEY PRODUCT LAUNCHES
             11.4.2 KEY ACQUISITIONS
             11.4.3 KEY COLLABORATIONS
             11.4.4 KEY EXPANSIONS
     11.5 COMPANY EVALUATION MATRIX
             11.5.1 STARS
             11.5.2 EMERGING LEADERS
             11.5.3 PARTICIPANTS
             11.5.4 PERVASIVE
                    FIGURE 32 CARTILAGE REPAIR AND REGENERATION MARKET: COMPETITIVE EVALUATION MATRIX (2019)

12 COMPANY PROFILES (Page No. - 127)
(Business overview, Products offered, Recent Developments, SWOT analysis, MNM view)*
     12.1 SMITH & NEPHEW PLC
          FIGURE 33 SMITH & NEPHEW: COMPANY SNAPSHOT (2019)
     12.2 DEPUY SYNTHES
          FIGURE 34 JOHNSON & JOHNSON: COMPANY SNAPSHOT (2019)
     12.3 ZIMMER BIOMET HOLDINGS, INC.
          FIGURE 35 ZIMMER BIOMET: COMPANY SNAPSHOT (2019)
     12.4 STRYKER CORPORATION
          FIGURE 36 STRYKER CORPORATION: COMPANY SNAPSHOT (2019)
     12.5 VERICEL CORPORATION
          FIGURE 37 VERICEL CORPORATION: COMPANY SNAPSHOT (2019)
     12.6 B. BRAUN MELSUNGEN AG
          FIGURE 38 B. BRAUN MELSUNGEN AG: COMPANY SNAPSHOT (2019)
     12.7 ANIKA THERAPEUTICS
          FIGURE 39 ANIKA THERAPEUTICS: COMPANY SNAPSHOT (2019)
     12.8 RTI SURGICAL
     12.9 CONMED CORPORATION
          FIGURE 40 CONMED CORPORATION: COMPANY SNAPSHOT (2019)
     12.10 ARTHREX, INC.
     12.11 REGROW BIOSCIENCES
     12.12 MEDIPOST
           FIGURE 41 MEDIPOST: COMPANY SNAPSHOT (2019)
     12.13 GEISTLICH PHARMA AG
     12.14 ALLOSOURCE
     12.15 ORTHOCELL LTD.
     12.16 BIOTISSUE SA

*Details on Business overview, Products offered, Recent Developments, SWOT analysis, MNM view might not be captured in case of unlisted companies.

13 APPENDIX (Page No. - 151)
     13.1 DISCUSSION GUIDE
     13.2 KNOWLEDGE STORE: MARKETSANDMARKETS’ SUBSCRIPTION PORTAL
     13.3 AVAILABLE CUSTOMIZATIONS
     13.4 RELATED REPORTS
     13.5 AUTHOR DETAILS

This market research study involves the extensive use of secondary sources, directories, and databases to identify and collect information useful for this technical, market-oriented, and financial study of the global cartilage repair and regeneration market. In-depth interviews were conducted with various primary respondents, including key industry participants, subject-matter experts (SMEs), C-level executives of key market players, and industry consultants, among other experts, to obtain and verify critical qualitative and quantitative information and assess market prospects. The size of the cartilage repair and regeneration market was estimated through various secondary research approaches and triangulated with inputs from primary research to arrive at the final market size.

Secondary Research

The secondary sources referred to for this research study include publications from government sources, such as World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), US Food and Drug Administration (FDA), and International Cartilage Regeneration & Joint Preservation Society (ICRS), Asian Cartilage Repair Society, Alliance for Regenerative Medicine; secondary sources such as corporate and regulatory filings (such as annual reports, SEC filings, investor presentations, and financial statements); business magazines and research journals; press releases; and trade, business, and professional associations. Secondary data was collected and analyzed to arrive at the overall size of the global cartilage repair and regeneration market, which was validated through primary research.

Primary Research

Extensive primary research was conducted after acquiring basic knowledge about the global cartilage repair and regeneration market scenario through secondary research. Several primary interviews were conducted with market experts from both the demand (such as personnel from the pharmaceutical and biopharmaceutical industry) and supply sides (such as C-level and D-level executives, product managers, marketing and sales managers of key manufacturers, and distributors) across four major regions—North America, Europe, Asia Pacific, and the Rest of the World. Approximately 80% and 20% of primary interviews were conducted with supply-side and demand-side participants, respectively. This primary data was collected through questionnaires, e-mails, online surveys, personal interviews, and telephonic interviews.

Cartilage Regeneration Market Size, and Share

To know about the assumptions considered for the study, download the pdf brochure

Data Triangulation

After arriving at the overall market size of the global cartilage repair and regeneration market through the methodology mentioned above, this market was split into several segments and subsegments. Market breakdown procedures were employed, wherever applicable, to arrive at the exact market value for the key segments and subsegments. The extrapolated market data was triangulated by studying various macroindicators and regional trends from both demand- and supply-side participants.

Report Objectives

  • To define, describe, and forecast the cartilage repair and regeneration market based on application, treatment modality, application site, end user, and region
  • To provide detailed information about the major factors influencing the market growth (such as drivers, opportunities, restraints, and challenges)
  • To strategically analyze micromarkets1 with respect to individual growth trends, prospects, and contributions to the overall cartilage repair and regeneration market
  • To analyze market opportunities for stakeholders and provide details of the competitive landscape for key players
  • To forecast the size of the market segments with respect to five major regions, namely, North America, Europe, Asia Pacific (APAC), and the Rest of the World
  • To profile the key players and comprehensively analyze their core competencies2 in terms of key developments, product portfolios, and financials
  • To track and analyze competitive developments such as product launches, agreements, partnerships, collaborations, acquisitions, and expansions in the cartilage repair and regeneration market

Available Customizations

With the given market data, MarketsandMarkets offers customizations as per the company’s specific needs. The following customization options are available for the report:

Geographic Analysis

  • Further breakdown of the APAC cartilage repair and regeneration market, by country.
  • Further breakdown of the European cartilage repair and regeneration market into Spain and Italy.
COVID-19

Get in-depth analysis of the COVID-19 impact on the Cartilage Repair/ Cartilage Regeneration Market

Benchmarking the rapid strategy shifts of the Top 100 companies in the Cartilage Repair/ Cartilage Regeneration Market

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Oct, 2020
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