Preparative and Process Chromatography Market Size, Share & Trends by Type (Preparative Chromatography (Chemicals & Reagents, Resins (Affinity, HIC, Ion Exchange), Columns, Systems, Services), Process Chromatography), End User (Pharma, Biotech) & Region - Global Forecast to 2028
Updated on : Aug 22, 2024
Preparative and Process Chromatography Market Size, Share & Trends
The size of global preparative and process chromatography market in terms of revenue was estimated to be worth $11.3 billion in 2023 and is poised to reach $15.6 billion by 2028, growing at a CAGR of 6.8% from 2023 to 2028. The comprehensive research encompasses an exhaustive examination of industry trends, meticulous pricing analysis, patent scrutiny, insights derived from conferences and webinars, identification of key stakeholders, and a nuanced understanding of market purchasing dynamics.
The growth in this market is attributed to the increasing need for biosimilars, rising demand for insulin and monocolonal antibodies, and growing use of LCMS in research. However, alternative methods or techniques restrain the growth of this market.
Preparative and Process Chromatography Market Trends
To know about the assumptions considered for the study, Request for Free Sample Report
Global Preparative and process chromatography Dynamics
DRIVER: Increasing demand for insulin and other biopharmaceutical products
In insulin purification Process chromatography plays an important role. The growing demand for insulin due to the increasing prevalence of insulin-dependent diabetes. The International Diabetes Federation (IDF) stated that over 537 million people had diabetes worldwide in 2021. The IDF has also projected that, in 2030, over 643 million people may have diabetes; by 2045, the number will escalate to 783 million. The increasing awareness about the available treatments among patients and clinicians results and rising prevalence of diabetes in a growing demand for insulin worldwide. This trend is, in turn, driving the growth of the process chromatography market.
RESTRAINT: High cost of instruments
Preparative and process chromatography systems are priced at a premium because of the features and technologies involved. The requirement of such systems in processes is crucial in SMEs in the oil & gas, food & beverage, and biotech & pharmaceutical industries and research & academic institutions. Thus, the capital cost spent on these systems increases significantly. Moreover, as academic research laboratories have controlled budgets, they find it difficult to afford such systems. The maintenance costs and other indirect expenses result in an overall increase in the total cost of ownership of these instruments. This restricts the adoption of chromatographic accessories & consumables among price-sensitive end users, such as research laboratories, academic institutes, and small companies. For instance, Merck KGaA (Germany) offers resins for USD 120–58,066 and supported fluid extraction columns, accessories, etc., for USD 146–1,001. Agilent Technologies (US) offers GC systems for USD 902–19,249, while Shimadzu Corporation (Japan) offers GC systems for USD 14,613.
OPPORTUNITY: Increasing demand for mAbs
Preparative and process chromatography plays a crucial role in purifying monoclonal antibodies (mAbs). Major biopharmaceutical players such as Pfizer Inc. (US), Novartis International AG (Switzerland), Boehringer Ingelheim International GmbH (Germany), Amgen Inc. (US), and Samsung Bioepis (South Korea) have increased their focus on mAbs with such promising opportunities. Another key factor supporting the growth of the mAbs market the rising number of mAbs approved by regulatory bodies. As of February 2023, well over 100 novel mAbs3 were approved for cancer, autoimmune and infectious diseases, and inflammatory conditions, among other indications (Source: US FDA 2023). The growing number of mAbs available in the market is expected to increase the demand for the preparative and process chromatography technique, thereby supporting the growth of the market.
CHALLENGE: Shortage of skilled professionals
Expertise with relevant experience and knowledge of the technique, mechanism, principle, resins, type of separation, and column packing is required for proper usage of chromatographic analytical technologies. Due to the lack of profound knowledge will likely incur several direct and indirect expenses, besides increasing researchers’ workload and time pressure which will also lead to inefficient practical experience and an insufficient understanding of data output. There is a significant shortage of skilled personnel for method development, validation, operation, and troubleshooting activities, which is expected to restrain the growth of the chromatography market in the coming years.
Preparative and Process Chromatography Ecosystem
Prominent companies in this market include well-established, financially stable manufacturers of preparative and process chromatography. These companies have been operating in the market for several years and possess diversified state-of-the-art technologies, product portfolios, and strong global sales and marketing networks. Prominent companies in this market include Thermo Fisher Scientific Inc. (US), Merck KGaA (Germany), Danaher Corporation (US), Sartorius AG (Germany), and Bio-Rad Laboratories, Inc. (US).
In 2022, Process chromatography segment to observe the highest growth rate of the preparative and process chromatography industry, by type.
Based on type, the preparative and process chromatography market is classified into preparative chromatography and process chromatography. Each segment has been further divided based on product and service. The process chromatography segment dominated the market in 2022. The large share of the segment can be attributed to the growing number of players in the process chromatography products and rise in number of research projects such as proteomics and genomics.
In 2022, pharmaceutical and biotechnology industries segment to dominate the preparative and process chromatography industry, by end user.
Based on the end user, the preparative and process chromatography market is segmented into pharmaceutical & biotechnology industries, food & nutraceutical industries, and research laboratories. The pharmaceutical & biotechnology industries segment dominated the market in 2022. The large share of this segment can be primarily attributed to the growing investments in pharmaceutical manufacturing sites and growing production of mAbs and insulin in industries like biotechnology and biopharmaceuticals.
In 2022, North America to dominate in preparative and process chromatography industry.
The global preparative and process chromatography market is segmented into North America, Europe, Asia Pacific, and Rest of the World. North America is expected to dominate during the forecast period, primarily due to the growing R&D expenditure by pharmaceutical & biotechnology companies, growing demand for insulin products, and rise in research funding for food safety testing.
To know about the assumptions considered for the study, download the pdf brochure
The preparative and process chromatography market is dominated by players such as Thermo Fisher Scientific Inc. (US), Merck KGaA (Germany), Danaher Corporation (US), Sartorius AG (Germany), and Bio-Rad Laboratories, Inc. (US).
Scope of the Preparative and Process Chromatography Industry
Report Metric |
Details |
Market Revenue Size in 2023 |
$11.3 billion |
Projected Revenue Size by 2028 |
$15.6 billion |
Industry Growth Rate |
Poised to Grow at a CAGR of 6.8% |
Market Driver |
Increasing demand for insulin and other biopharmaceutical products |
Market Opportunity |
Increasing demand for mAbs |
This research report categorizes the preparative and process chromatography market to forecast revenue and analyze trends in each of the following submarkets:
By Region
- North America
- Europe
- Asia Pacific
- Rest of the World
By Type
- Process chromatography
- Preparative chromatography
By End User
- Pharmaceutical & Biotechnology Industries
- Food & Nutraceutical Industries
- Research Laboratories
Recent Developments of Preparative and Process Chromatography Industry
- In 2023, Thermo Fisher acquired MarqMetrix, a privately held developer of Raman-based spectroscopy solutions for inline measurement. The acquisition added highly complementary Raman-based inline PAT to Thermo Fisher’s portfolio.
- In 2023, Waters Corporation and Sartorius collaborated to develop integrated analytical solutions for downstream biomanufacturing, expanding their joint agreement that began with upstream bioprocessing analytics.
- In 2022, Shimadzu Corporation developed the Brevis GC-2050. This new space-saving GC delivers high analytical performance in a rugged design to meet laboratory requirements.
Frequently Asked Questions (FAQ):
What is the projected market revenue value of the global preparative and process chromatography market?
The global preparative and process chromatography market boasts a total revenue value of $15.6 billion by 2028.
What is the estimated growth rate (CAGR) of the global preparative and process chromatography market?
The global preparative and process chromatography market has an estimated compound annual growth rate (CAGR) of 6.8% and a revenue size in the region of $11.3 billion in 2023.
To speak to our analyst for a discussion on the above findings, click Speak to Analyst
The objective of the study is to analyze the key market dynamics, such as drivers, opportunities, challenges, restraints, and key player strategies. To track company developments such as acquisitions, product launches, expansions, collaborations, agreements, and partnerships of the leading players, the competitive landscape of the preparative and process chromatography market to analyze market players on various parameters within the broad categories of business and product strategy. Top-down and bottom-up approaches were used to estimate the market size. To estimate the market size of segments and subsegments, the market breakdown and data triangulation were used.
The four steps involved in estimating the market size are
Collecting Secondary Data
The secondary research data collection process involves the usage of secondary sources, directories, databases (such as Bloomberg Businessweek, Factiva, and D&B), annual reports, investor presentations, and SEC filings of companies. Secondary research was used to identify and collect information useful for the extensive, technical, market-oriented, and commercial study of the market. A database of the key industry leaders was also prepared using secondary research.
Collecting Primary Data
The primary research data was conducted after acquiring knowledge about the market scenario through secondary research. A significant number of primary interviews were conducted with stakeholders from both the demand side (such as pharmaceutical & biotechnology industries, food & nutraceutical industries, and research laboratories) and supply side (such as included various industry experts, such as Directors, Chief X Officers (CXOs), Vice Presidents (VPs) from business development, marketing, and product development teams, product manufacturers, wholesalers, channel partners, and distributors) across major countries of North America, Europe, Asia Pacific, the Middle East & Africa, and Latin America. Approximately 40% of the primary interviews were conducted with stakeholders from the demand side, while those from the supply side accounted for the remaining 60%. Primary data for this report was collected through questionnaires, emails, and telephonic interviews.
A breakdown of the primary respondents is provided below:
Breakdown of Primary Participants:
Note 1: *Others include sales managers, marketing managers, and product managers.
Note 2: Tiers are defined based on a company’s total revenue as of 2022: Tier 1=> USD 1 billion, Tier 2 = USD 500 million to USD 1 billion, and Tier 3=< USD 500 million.
To know about the assumptions considered for the study, download the pdf brochure
Market Size Estimation
All major product manufacturers offering various preparative and process chromatography were identified at the global/regional level. Revenue mapping was done for the major players and was extrapolated to arrive at the global market value of each type of segment. The market value preparative and process chromatography market was also split into various segments and subsegments at the region and country level based on:
- Product mapping of various manufacturers for each type of market at the regional and country-level
- Relative adoption pattern of each market among key application segments at the regional and/or country-level
- Detailed primary research to gather qualitative and quantitative information related to segments and subsegments at the regional and/or country level.
- Detailed secondary research to gauge the prevailing market trends at the regional and/or country-level
Global Preparative and process chromatography Market Size: Top Down Approach
To know about the assumptions considered for the study, Request for Free Sample Report
Global Preparative and process chromatography Market Size: Bottom-Up Approach
Data Triangulation
After arriving at the overall market size—using the market size estimation processes—the market was split into several segments and subsegments. To complete the overall market engineering process and arrive at the exact statistics of each market segment and subsegment, data triangulation and market breakdown procedures were employed, wherever applicable. The data was triangulated by studying various factors and trends from both the demand and supply sides in the Preparative and process chromatography industry.
Market Definition
Bioimpedance analysis (also known as bioelectric impedance analysis) is a method of assessing body composition, which measures body fat in relation to lean body mass. It determines the resistance to the flow of electric current as it passes through the body. Preparative and process chromatography are medical devices that are used to measure the impedance of biological tissues. The opposition that tissue or substance presents to the flow of an alternating electrical current is known as impedance.
Key Stakeholders
- Senior Management
- Finance/Procurement Department
- R&D Department
- End user/Operator
Report Objectives
- To provide detailed information about the factors influencing the market growth (such as drivers, restraints, opportunities, and challenges)
- To define, describe, segment, and forecast the preparative and process chromatography market by type, end-user, and region
- To analyze market opportunities for stakeholders and provide details of the competitive landscape for key players
- To analyze micro markets with respect to individual growth trends, prospects, and contributions to the overall market
- To forecast the size of the market in five main regions along with their respective key countries, namely, North America, Europe, the Asia Pacific, Rest of the world.
- To profile key players in the market and comprehensively analyze their core competencies and market shares
- To track and analyze competitive developments, such as acquisitions; product launches; expansions; collaborations, agreements, & partnerships; and R&D activities of the leading players in the market.
- To benchmark players within the market using the Competitive Leadership Mapping framework, which analyzes market players on various parameters within the broad categories of business and product strategy
Available Customizations
MarketsandMarkets offers the following customizations for this market report:
- Additional country-level analysis of the Preparative and process chromatography market
- Profiling of additional market players (up to 5)
Product Analysis
- Product matrix, which provides a detailed comparison of the product portfolio of each company in the Preparative and process chromatography Market
Growth opportunities and latent adjacency in Preparative and Process Chromatography Market