Whole Exome Sequencing Market

Whole Exome Sequencing Market by Product [Systems, Kits (Library Preparation, Target Enrichment)], Services (Sequencing), Technology (Sequencing by Synthesis), & by Application (Cancer, Monogenic disorders) - Global Forecast to 2018

Report Code: BT 2646 Aug, 2014, by marketsandmarkets.com

Whole Exome Sequencing (WES) is next-generation technology used for strategically sequencing the coding region of the genome, i.e. the exon. The exome, which is the total of all exons of an organism, represents only 1–2% of the total genome and is actually converted into proteins after translation. It is responsible for the occurrence of nearly 85% of genetic diseases. Whole exome sequencing is widely used for identifying and determining genetic variants responsible for various diseases such as Miller Syndrome and Alzheimer’s disease.

This global whole exome sequencing market was valued at $326.6 million in 2013 and is expected to grow at a CAGR of 22.0% from 2013 to 2018, to reach $884.1 million by 2018.

The rapidly decreasing costs of sequencing, adoption of WES technology by new consumers, strategic alliances amongst key players and research institutes, and increase in use of WES technology for new scientific applications are driving the demand for this technology. The most important factor increasing the preference of WES over whole-genome sequencing is its low-cost sequencing capability. However, a lack of skilled professionals and high reliability on government grants are some of the factors hindering the growth of the WES market.

Based on products and services, the market is segmented into systems and platforms, kits (consumables), and services (sequencing and data analysis). Based on applications, the market is majorly divided into diagnostics, drug discovery and development, personalized medicine, and animal and plant research, among others. Based on end users, the market is divided into research centers, academic and government institutions, hospitals and clinics, and pharmaceutical and biotech companies, among others. Based on geography, the market is divided between North America, Europe, Asia, and Rest of the World (Middle East, Latin America, and Pacific countries). North America is the largest market for whole exome sequencing, owing to the relatively large federal grants from the National Institute of Health (NIH) there.

Major players in the global whole exome sequencing market include Illumina, Inc. (U.S.) Life Technologies (acquired by Thermo Fisher Scientific, Inc.) (U.S.), Roche NimbleGen, Inc. (U.S.), Agilent Technologies (U.S.), BGI (Beijing Genomics Institute, China), Eurofins Genomics, Inc. (Germany), Sengenics (U.S.), GENEWIZ, Inc. (U.S.), Knome, Inc. (U.S.), Macrogen, Inc. (South Korea), and Ambry Genetics (U.S.), among others.

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Scope of the Report

This research report categorizes the global whole exome sequencing market into the following segments and sub-segments:

By Technology

  • Sequencing by Synthesis
  • Ion Semiconductor Sequencing
  • Others

By Products and Services

  • Products
  • Systems
  • Kits
      • DNA Fragmentation End Repair, A-Tailing and Size Selection
      • Library Preparation Kits
      • Target Enrichment Kits
  • Services
  • Sequencing Services
  • Data Analysis Services
  • Others

By Applications

  • Diagnostics
  • Cancer
  • Monogenic Disorders
  • Diabetes
  • Others
  • Drug Discovery and Development
  • Personalized Medicine
  • Agriculture and Animal Research
  • Others

By End Users

  • Research Center, Academic and Government Institutions
  • Hospitals and Clinics
  • Pharmaceutical and Biotechnology Companies
  • Others

By Geography

  • North America
  • Europe
  • Asia
  • Rest of the World (RoW)

Advances in DNA sequencing have transformed genomics and paved the way for whole exome sequencing in research. Whole exome sequencing is cost-efficient and quick, as compared to whole-genome sequencing. Sequencing the exome is also considered more effective, as exons possess 85% of disease traits. Thus, WES systems, kits, and services have seen increased adoption by researchers as they not only simplify work but also save time.

Technological advancements in sequencing systems, global alliances amongst leading research institutes to boost drug discovery, and an increase in life science and R&D expenditure are the key factors that are expected to drive the growth of this market. Primary factors that are restraining the growth of this market include high instrument costs, the need for skilled professionals, and high reliance on grants and funds.

The global whole exome sequencing market is categorized into five broad segments, namely, products and services, technologies, applications, end users, and geography. The global WES products and services market, by products, comprises systems and kits. The kits market is further segmented into DNA fragmentation, end repair, A-tailing, size selection kits, library preparation kits, and target enrichment kits. The WES products and services market, by services, comprises sequencing and data analysis services. The services market accounted for the largest share of the global WES products and services market in 2013.

The whole exome sequencing  market, by applications, includes diagnostics, drug discovery and development, personalized medicine, and animal and plant research. In 2013, the diagnostics market held the largest share of the global WES applications market. The market, by end users, comprises research centers, academic and government institutions, hospitals and clinics, and pharmaceutical and biotech companies, among others. In 2013, research centers and academic and government institutions accounted for the largest share of the global market, by end users. On the basis of geography, this market is classified into four regions, namely, North America, Europe, Asia and Rest of the World (RoW).

Global Whole Exome Sequencing Market, by Geography, 2013 – 2018

Whole Exome Sequencing Market

Source: MarketsandMarkets Analysis

This global whole exome sequencing market was valued at $326.6 million in 2013 and is expected to grow at a CAGR of 22.0% from 2013 to 2018, to reach $884.1 million by 2018. The market is dominated by North America, followed by Europe, Asia, and the Rest of the World (RoW). North America is expected to maintain its leadership in the market in the coming years. Growth in the North American market is likely to be driven by factors such as the increasing use of exome sequencing in rare disease research, increased government funding, and large number of sequencing-related conferences and annual meetings hosted by the U.S.

The major players in the global whole exome sequencing market include Illumina, Inc. (U.S.) Life Technologies (acquired by Thermo Fisher Scientific, Inc.) (U.S.), Roche NimbleGen, Inc. (U.S.), Agilent Technologies (U.S.), BGI (Beijing Genomics Institute, China), Eurofins Genomics, Inc. (Germany), Sengenics (U.S.), GENEWIZ, Inc. (U.S.), Knome, Inc. (U.S.), Macrogen, Inc. (South Korea), and Ambry Genetics (U.S.), among others.

Table of Contents 
 
1 Introduction (Page No. - 24)
    1.1 Objectives of the Study
    1.2 Report Description
    1.3 Markets Covered
    1.4 Stakeholders
    1.5 Research Methodology
          1.5.1 Secondary Research
          1.5.2 Primary Research
                   1.5.2.1 Key Data Points From Primary Sources
          1.5.3 Market Size Estimation Methodology
          1.5.4 Market Forecast
          1.5.5 Market Data Validation and Data Triangulation
    1.6 Assumptions

2 Executive Summary (Page No. - 41)

3 Market Overview (Page No. - 47)
    3.1 Introduction
    3.2 Market Dynamics
          3.2.1 Drivers
                   3.2.1.1 the Low Cost and High Speed of the Wes Technology to Drive the Growth of the Market
                   3.2.1.2 Increasing Number of New Scientific Applications to Fuel the Market Growth
                   3.2.1.3 Adoption of Wes Technology By New Consumers to Propel the Market Growth
                   3.2.1.4 Global Alliances Amongst Leading Research Institutes to Trigger Drug Discovery
                   3.2.1.5 Entry of New Players Is Propelling the Growth of the Wes Market
          3.2.2 Restraints
                   3.2.2.1 Need for Skilled Professionals
                   3.2.2.2 High Reliability on Grants to Restrict Growth
                   3.2.2.3 Ethical and Legal Issues Related to Whole Exome Sequencing
          3.2.3 Opportunities
                   3.2.3.1 Personalized Medicine to Fuel the Demand for Wes Technology
    3.3 Market Share Analysis
          3.3.1 Whole Exome Sequencing Products Market, By Key Player
          3.3.2 WES Services Market, By Key Player

4 Whole Exome Sequencing Market,  By Products and Services (Page No. - 68)
    4.1 Introduction
    4.2 Systems
          4.2.1 Hiseq Series
                   4.2.1.1 Hiseq 2500 and Hiseq 1500
          4.2.2 Miseq
          4.2.3 ION torrent Platforms
                   4.2.3.1 ION PGM and ION Proton
    4.3 Kits
          4.3.1 Introduction
          4.3.2 DNA Fragmentation, End Repair, A-Tailing, and Size Selection Kits
          4.3.3 Library Preparation Kits
          4.3.4 Target Enrichment Kits
    4.4 Services
          4.4.1 Introduction
          4.4.2 Sequencing Services Market
          4.4.3 Data Analysis (Bioinformatics) Services
          4.4.4 Other Services

5 Global Whole Exome Sequencing Market,  By Technology (Page No. - 95)
    5.1 Introduction
    5.2 Sequencing By Synthesis (SBS)
          5.2.1 Technology
          5.2.2 Advantages
          5.2.3 Challenges
          5.2.4 Applications
          5.2.5 Platforms
    5.3 ION Semiconductor Sequencing
          5.3.1 Technology
          5.3.2 Advantages
          5.3.3 Limitations
          5.3.4 Applications
          5.3.5 Platforms
    5.4 Other Technologies
          5.4.1 Sequencing By Ligation (SBL)
                   5.4.1.1 Technology
                   5.4.1.2 Advantages
                   5.4.1.3 Limitations
                   5.4.1.4 Applications
          5.4.2 Pyrosequencing
                   5.4.2.1 Technology
                   5.4.2.2 Advantages
                   5.4.2.3 Applications

6 Whole Exome Sequencing Market, By Application (Page No. - 105)
    6.1 Introduction
    6.2 Diagnostics
          6.2.1 Cancer Diagnostics
          6.2.2 Monogenic (Mendelian) Disorders
          6.2.3 Monogenic Types of Diabetes
          6.2.4 Other Diagnostic Applications
                  6.2.4.1 Common Diseases and Complex Disorders
                  6.2.4.2 Movement Disorders
                  6.2.4.3 Hiv
    6.3 Drug Discovery and Development
    6.4 Personalized Medicine
    6.5 Agriculture & Animal Research
    6.6 Other Applications

7 Global Wholeexome Sequencing Market,  By End User (Page No. - 125)
    7.1 End Users
    7.2 Introduction
          7.2.1 Research Centers and Academic & Government Institutes
          7.2.2 Hospitals and Clinics
          7.2.3 Pharmaceutical & Biotechnology Companies
          7.2.4 Other End Users

8 Global Whole Exome Sequencing Market,  By Geography (Page No. - 135)
    8.1 Introduction
    8.2 North America
          8.2.1 Increasing Use of Whole Exome Sequencing for Diagnosis of Rare Diseases Propels the Market Growth
          8.2.2 Government Funds for Exome Sequencing to Boost the Market
          8.2.3 Favorable Initiatives By the Canadian Government to Trigger Wes Market in the Country
          8.2.4 Conferences & Annual Meetings to Create Awareness About Wes Technologies
    8.3 Europe
          8.3.1 Investment in Rare Disease Research Likely to Boost the Wes Market in Europe
          8.3.2 Belgium to Contribute Substantially to Market Growth in Europe
          8.3.3 Increasing Funding for  Molecular Diagnostics in Europe Is Likely to Propel the Growth of the Wes Market
          8.3.4 Conferences & Meetings Hosted in Europe to Fuel the Market Growth
    8.4 Asia
          8.4.1 Asian Countries Are Increasingly Focusing on Research in Wes
          8.4.2 Strategic Expansions and Aquisitions By Key Players in China to Boost the Market
          8.4.3 Regular Funding From Indian Government, An Impetus to the Wes Market
          8.4.4 Large Number of Conferences and Symposia in Asia to Drive Market Growth
    8.5 Rest of the World (ROW)
          8.5.1 Bioinformatics and Biotechnology Research in Latin America to Propel the Growth of the Market
          8.5.2 Genomic & Proteomic Research in Australia to Drive the Growth of the Market
          8.5.3 Flourishing Biotechnology & Pharmaceutical Markets in Brazil to Bolster the Growth of the Market

9 Competitive Landscape (Page No. - 190)
    9.1 Introduction
    9.2 Agreements, Partnerships, & Collaborations
    9.3 New Product Launches
    9.4 Expansions
    9.5 Acquisitions
    9.6 Others

10 Company Profiles (Page No. - 211)
     10.1 Illumina, Inc.
             10.1.1 Company Snapshot
             10.1.2 Financial Overview
             10.1.3 Products and Services
             10.1.4 Key Strategies
             10.1.5 Recent Developments
             10.1.6 SWOT
             10.1.7 MNM View
     10.2 Thermo Fisher Scientific, Inc.
             10.2.1 Company Snapshot
             10.2.2 Financial Overview
             10.2.3 Product Portfolio
             10.2.4 Key Strategies
             10.2.5 Recent Developments
             10.2.6 SWOT
             10.2.7 MNM View
     10.3 Beijing Genomics Institute (Bgi)
             10.3.1 Company Snapshot
             10.3.2 Financial Overview
             10.3.3 Services
             10.3.4 Key Strategies
             10.3.5 Recent Developments
             10.3.6 SWOT
             10.3.7 MNM View
     10.4 Macrogen, Inc.
             10.4.1 Company Snapshot
             10.4.2 Financial Overview
             10.4.3 Services
             10.4.4 Key Strategy
             10.4.5 Recent Developments
             10.4.6 SWOT
             10.4.7 MNM View
     10.5 Eurofins Genomics, Inc.
             10.5.1 Company Snapshot
             10.5.2 Financial Overview
             10.5.3 Services
             10.5.4 Key Strategies
             10.5.5 Recent Developments
             10.5.6 SWOT
             10.5.7 MNM View
     10.6 Agilent Technologies, Inc.
             10.6.1 Company Snapshot
             10.6.2 Financial Overview
             10.6.3 Products and Services
             10.6.4 Key Strategies
             10.6.5 Recent Developments
     10.7 Ambry Genetics
             10.7.1 Company Snapshot
             10.7.2 Financial Overview
             10.7.3 Services
             10.7.4 Key Strategy
             10.7.5 Recent Developments
     10.8 Genewiz, Inc.
             10.8.1 Company Snapshot
             10.8.2 Financial Overview
             10.8.3 Services
             10.8.4 Key Strategy
             10.8.5 Recent Developments
     10.9 Knome, Inc.
             10.9.1 Company Snapshot
             10.9.2 Financial Overview
             10.9.3 Products and Services
             10.9.4 Key Strategies
             10.9.5 Recent Developments
     10.10 Roche Nimblegen, Inc.
             10.10.1 Company Snapshot
             10.10.2 Financial Overview
             10.10.3 Products and Services
             10.10.4 Key Strategy
             10.10.5 Recent Developments
     10.11 Sengenics
             10.11.1 Company Snapshot
             10.11.2 Financial Overview
             10.11.3 Services
             10.11.4 Key Strategy
             10.11.5 Recent Developments


List of Tables (80 Tables)

Table 1 Price Comparison for Whole Genome and Whole Exome Sequencing
Table 2 Employee Split for the Year 2013, By Geography
Table 3 Global Whole Exome Sequencing Market, By Products and Services, 2011–2018 ($Million)
Table 4 Global WES Products Market, By Type, 2011–2018 ($Million)
Table 5 Global Whole Exome Sequencing Products Market, By Region, 2011–2018 ($Million)
Table 6 Technical Specifications of Sequencing Systems
Table 7 Global WES Systems Market, By Region, 2011–2018 ($Million)
Table 8 Table: Comparison Between Sequencing Kits
Table 9 Global Whole Exome Sequencing Kits Market, By Type, 2011–2018 ($Million)
Table 10 Global WES Kits Market, By Region, 2011–2018 ($Million)
Table 11 DNA Fragmentation, End Repair, A-Telling, and Size Selection Kits Market, By Region, 2011–2018 ($Million)
Table 12 Whole Exome Sequencing Market Size for Library Preparation Kits, By Region, 2011–2018 ($Million)
Table 13 Market Size for Target Enrichment Kits, By Region, 2011–2018 ($Million)
Table 14 Global Whole Exome Sequencing Services Market, By Type, 2011–2018 ($Million)
Table 15 Global WES Services Market, By Region, 2011–2018 ($Million)
Table 16 Market Size for Sequencing Services, By Geography, 2011–2018 ($Million)
Table 17 Market Size for Data Analysis Services, By Region, 2011–2018 ($Million)
Table 18 Other Services Market, By Region, 2011–2018 ($Million)
Table 19 Global Market Size, By Technology, 2011–2018 ($Million)
Table 20 Market Size for Sequencing By Synthesis Technology, By Region, 2011–2018 ($Million)
Table 21 Market Size for ION Semiconductor Sequencing Technology, By Region, 2011–2018 ($Million)
Table 22 Market Size for Other Sequencing Technologies, By Region, 2011–2018 ($Million)
Table 23 Global Whole Exome Sequencing Market Size, By Application, 2011–2018 ($Million)
Table 24 Market Size for Diagnostic Applications, By Type, 2011–2018 ($Million)
Table 25 Market Size for Diagnostic Applications, By Region, 2011–2018 ($Million)
Table 26 Market Size for Cancer Diagnostics, By Region, 2011–2018 ($Million)
Table 27 Market Size for Monogenic Disorder Diagnostics, By Region, 2011–2018 ($Million)
Table 28 Market Size for Monogenic Types of Diabetes, By Region, 2011–2018 ($Million)
Table 29 Market Size for Other Diagnostic Applications, By Region, 2011–2018 ($Million)
Table 30 Market Size for Drug Discovery and Development, By Region, 2011–2018 ($Million)
Table 31 Market Size for Personalized Medicine, By Region, 2011–2018 ($Million)
Table 32 Market Size for Agriculture and Animal Research, By Region, 2011–2018 ($Million)
Table 33 Market Size for Other Applications, By Region, 2011–2018 ($Million)
Table 34 Global Whole Exome Sequencing Market Size, By End User, 2011–2018 ($Million)
Table 35 Market Size for Research Centers and Academic & Government Institutes, By Region, 2011–2018 ($Million)
Table 36 Market Size for Hospitals and Clinics, By Region, 2011–2018 ($Million)
Table 37 Market Size for Pharmaceutical and Biotechnology Companies, By Region, 2011–2018 ($Million)
Table 38 Market Size forother End Users, By Region, 2011–2018 ($Million)
Table 39 Market Size, By Region, 2011–2018 ($Million)
Table 40 Conferences/Meetings/forums/Workshops in the U.S., 2014
Table 41 North America: Whole Exome Sequencing Market Size, By Technology, 2011–2018 ($Million)
Table 42 North America: Market Size, By Products and Services, 2011–2018 ($Million)
Table 43 North America: Whole Exome Sequencing Products Market Size, By Type, 2011–2018 ($Million)
Table 44 North America: WES Kits Market Size, By Type, 2011–2018 ($Million)
Table 45 North America: WES Services Market Size, By Type, 2011–2018 ($Million)
Table 46 North America: Market Size, By Application, 2011–2018 ($Million)
Table 47 North America: Market Size for Diagnostic Applications, By Type, 2011–2018 ($Million)
Table 48 North America: Market Size, By End User, 2011–2018 ($Million)
Table 49 Conferences/Meetings/Forums/Workshops in Europe, 2014
Table 50 Europe: Whole Exome Sequencing Market Size, By Technology, 2011–2018 ($Million)
Table 51 Europe: Market Size, By Products and Services, 2011–2018 ($Million)
Table 52 Europe: Whole Exome Sequencing Products Market Size, By Type, 2011–2018 ($Million)
Table 53 Europe: WES Kits Market Size, By Type, 2011–2018 ($Million)
Table 54 Europe: WES Services Market Size, By Type, 2011–2018 ($Million)
Table 55 Europe: Market Size, Application, 2011–2018 ($Million)
Table 56 Europe: Market Size for Diagnostic Applications, By Type, 2011–2018 ($Million)
Table 57 Europe: Market Size, By End User, 2011–2018 ($Million)
Table 58 Conferences/Meetings/Forums/Workshops in Asia, 2014
Table 59 Asia: Whole Exome Sequencing Market Size, By Technology, 2011–2018 ($Million)
Table 60 Asia: Market Size, By Products and Services, 2011–2018 ($Million)
Table 61 Asia: WES Products Market Size, By Type, 2011–2018 ($Million)
Table 62 Asia: WES Kits Market Size, By Type, 2011–2018 ($Million)
Table 63 Asia: WES Services Market Size, By Type, 2011–2018 ($Million)
Table 64 Asia: Market Size, Application, 2011–2018 ($Million)
Table 65 Asia: Market Size for Diagnostic Applications, By Type, 2011–2018 ($Million)
Table 66 Asia: Market Size, By End User, 2011–2018 ($Million)
Table 67 ROW: Whole Exome Sequencing Market Size, By Technology, 2011–2018 ($Million)
Table 68 ROW: Market Size, By Products and Services, 2011–2018 ($Million)
Table 69 ROW: Whole Exome Sequencing Products Market Size, By Type, 2011–2018 ($Million)
Table 70 ROW: Whole Exome Sequencing Kits Market Size, By Type, 2011–2018 ($Million)
Table 71 ROW: WES Services Market Size, By Type, 2011–2018 ($Million)
Table 72 ROW: Market Size, By Application, 2011–2018 ($Million)
Table 73 ROW: Market Size for Diagnostic Applications, By Type, 2011–2018 ($Million)
Table 74 ROW: Market Size, By End User, 2011–2018 ($Million)
Table 75 Agreement, Partnerships, & Collaborations, 2011–2014
Table 76 Key Players Focusing on New Product Launches, 2011–2014
Table 77 New Product Launches, 2011–2014
Table 78 Expansions, 2011–2013
Table 79 Acquisitions, 2011–2014
Table 80 Others, 2011–2014


List of Figures (26 Figures)

Figure 1 Research Methodology
Figure 2 Sampling Frame: Primary Research
Figure 3 Market Size Estimation Methodology (1/3)
Figure 4 Market Size Estimation Methodology (2/3)
Figure 5 Market Size Estimation Methodology (3/3)
Figure 6 Market Sizing ($Value Analysis)
Figure 7 Market Share Assessment
Figure 8 Market Forecasting Model
Figure 9 Data Triangulation Methodology
Figure 10 Global Market Size, By Products and Services (2013–2018)
Figure 11 Global Market Size, By Geography, 2013 ($Million)
Figure 12 Market Dynamics
Figure 13 Whole Exome Sequencing Products Market Share, By Key Player
Figure 14 Whole Exome Sequencing Products Market Share, By Key Player
Figure 15 Market Segmentation
Figure 16 Commonly Available Sequencing Kits
Figure 17 DNA Fragmentation, End Repair, A-Tailing, and Size Selection Kits Workfolw
Figure 18 Wes Technology Market Segmentation
Figure 19 Market, By Application
Figure 20 Market, By End User
Figure 21 Geographic Split for Whole Exome Sequencing Market, By Products and Services, 2013 Vs. 2018 ($Million)
Figure 22 Global Market: Key Growth Strategies, 2011–2014
Figure 23 Key Players Focusing on Agreements, Partnerships, & Collaborations, 2011–2014
Figure 24 Key Players Focusing on Expansions, 2011–2014
Figure 25 Key Players Focusing on Acquisitions, 2011–2014
Figure 26 Key Players Focusing on Other Strategies, 2011–2014


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