Peptide Synthesis Market by Product (Reagent, Synthesizer, Chromatography), Technology (Solid Phase, Liquid Phase, and Hybrid & Recombinant), End User (Pharmaceuticals & Biotechnology, CRO), and Region - Global Forecast to 2023
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Request Now[171 Pages Report] The overall peptide synthesis market was valued at USD 292.4 million in 2017 and is projected to reach USD 426.4 million by 2023, at a CAGR of 6.5% during the forecast period. Market growth can be attributed to increasing use of peptides in pharmaceutical drugs, increase in research activities and availability of funding for R&D, and the development of advanced peptide synthesizers. The base year considered for the study is 2017, and the forecast has been provided for the period between 2018 and 2023.
Market Dynamics
Drivers
- Increasing use of peptides in pharmaceutical drugs
- Increase in research activities and availability of funding for R&D
- Development of advanced peptide synthesizers
Restraints
- Lack of a unified set of regulations for therapeutic peptides
Opportunities
- Emerging markets in the Asia Pacific region
Challenges
- Issues associated with the route of administration of peptide drugs
Increasing use of peptides in pharmaceutical drugs drives the global peptide synthesis market
Peptides are highly active and highly specific drug substances. Due to the diversity of their biological functions, they are used in an extensive range of therapeutic areas. Also, they are increasingly entering drug development pathways as potential active pharmaceutical ingredients due to their large chemical space, high biological activity, high specificity, relative ease of synthesis, ready availability, and low toxicity.
Oncology, diabetes, and obesity are three prominent therapeutic areas in which peptides generate billions of dollars in revenues. As a drug modality, peptides and peptidomimetics occupy the interface between small molecules and larger biological drugs with the potential to have the specificity of antibodies and the bioavailability of small molecules. Moreover, peptides provide researchers with viable options for discovery, optimization, and manufacture, as they can be synthesized chemically or expressed by recombinant systems. As a result of these advantages, pharmaceutical companies are increasingly focusing on the development of peptide-based drugs.
The following are the major objectives of the study.
- To define, describe, and forecast the peptide synthesis market on the basis of product, technology, end user, and region
- To provide detailed information about factors influencing market growth (drivers, restraints, opportunities, and industry-specific challenges)
- To strategically analyze micromarkets with respect to the individual growth trends, prospects, and contributions to the overall market
- To analyze market opportunities for stakeholders and provide details of the competitive landscape for key players
- To forecast the size of the market segments in North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa
- To profile key players and comprehensively analyze their market shares and core competencies in the global market
- To track and analyze competitive developments such as partnerships, agreements, & collaborations; mergers & acquisitions; product developments; and geographical expansions in the global market
During this research study, major players operating in the peptide synthesis market in various regions have been identified, and their offerings, regional presence, and distribution channels have been analyzed through in-depth discussions. Top-down and bottom-up approaches have been used to determine the overall market size. Sizes of the other individual markets have been estimated using the percentage splits obtained through secondary sources such as Hoovers, Bloomberg BusinessWeek, and Factiva, along with primary respondents. The entire procedure includes the study of the annual and financial reports of the top market players and extensive interviews with industry experts such as CEOs, VPs, directors, and marketing executives for key insights (both qualitative and quantitative) pertaining to the market. The figure below shows the breakdown of the primaries on the basis of the company type, designation, and region considered during the research study.
To know about the assumptions considered for the study, download the pdf brochure
The prominent players in the global peptide synthesis market are GenScript Biotech Corporation (China), AAPPTec (US), Bachem (Switzerland), AnaSpec (US), Biotage (Sweden), CEM Corporation (US), Gyros Protein Technologies (Sweden), Advanced ChemTech (US), New England Peptide, Inc (US) and Merck KGaA (Germany).
Major Market Developments
- In 2018, CEM Corporation launched the Liberty PRIME, automated microwave peptide synthesizer.
- In 2017, Merck acquired Grzybowski Scientific Inventions (GSI) (US). This acquisition helped the company to expand its chemical synthesis portfolio.
- In 2015, Merck acquired Sigma-Aldrich Corporation (US). This acquisition strengthened Mercks Life Science segment. Sigma-Aldrichs SAFC Commercial business is now a part of Mercks Life Science segment
Target Audience:
- Biotechnology & pharmaceutical companies
- Market research and consulting firms
- Venture capitalists and investors
- Research & development companies
- Contract research organizations (CROs)
- Academic research institutes
- Government institutes
Report Scope
Peptide Synthesis Market, By Product
- Reagents
- Equipment
- Peptide Synthesizers
- Chromatography equipment
- Lyophilizers
Peptide Synthesis Market, By Technology
- Solid-phase Peptide Synthesis
- Liquid-phase Peptide Synthesis
- Hybrid & Recombinant Technology
Peptide Synthesis Market, By End User
- Pharmaceutical and Biotechnology Companies
- Contract Development and Manufacturing Organizations
- Academic and Research Institutes
Peptide Synthesis Market, By Region
- North America
- US
- Canada
- Europe
- Germany
- France
- UK
- Italy
- Spain
- Rest of Europe
- Asia Pacific
- Japan
- China
- India
- Rest of Asia Pacific
- Latin America
- Middle East and Africa
Critical questions which the report answers
- What are new application areas which the peptide synthesis companies are exploring?
- Which are the key players in the market and how intense is the competition?
Available customizations
Based on the given market data, MarketsandMarkets offers customizations in the reports as per the clients specific requirements. The available customization options are as follows:
Geographic Analysis
- Further breakdown of the Rest of Asia Pacific market into South Korea, Australia, New Zealand, and others
- Further breakdown of the Rest of Europe (RoE) market into Belgium, Russia, the Netherlands, Switzerland, and others
- Further breakdown of the Rest of Latin America(RoLATAM) market into Argentina, Colombia, Chile, and others
Company Information
- Detailed analysis and profiling of additional market players
The overall peptide synthesis market is projected to reach USD 426.4 million by 2023 from USD 310.5 million in 2018, at a CAGR of 6.5% during the forecast period. Factors such as the growing use of peptides in pharmaceutical drugs, increase in research activities and availability of funding for R&D, and the development of advanced peptide synthesizers are expected to drive the growth of the market.
Peptides are organic molecules consisting of amino acids linked by a peptide (amide) bond. Peptide synthesis is the process of making short sequences of peptides by the condensation reaction of the carboxyl group of one amino acid to the amino group of another.
The peptide synthesis market has been segmented, on the bassis of product, into reagents and equipment. The market for equipment segment is expected to grow at the highest CAGR between 2018 and 2023. On the other hand, among all the equipment, peptide synthesizers are most widely used for peptide synthesis process. The high adoption of these instruments is contributing to the rapid growth of the market.
The peptide synthesis market in APAC is expected to grow at the highest CAGR during the forecast period. With significant growth in the research industry in the past few years, China and India have emerged as high-growth markets peptide synthesis. The research industry in this region has grown significantly over the years; manufacturers are now focusing on providing well-established technologies to ensure sustainable and strong revenue growth from this region. Biotechnology-based drugs are anticipated to be one of the key drivers for the research industry, as reflected in the increase in research being undertaken and government funds provided for these drugs. Thus, the increasing demand for novel antibody and protein-based drugs along with growing investments by the public and private sectors in life science research are expected to drive the APAC market in the coming years.
Solid phase synthesis technology to drive the growth of peptide synthesis market
Solid-Phase Synthesis
Solid-phase synthesis is the synthesis of chemical compounds whereby the reactant molecule is chemically bound to an insoluble material. It is a step-wise, cyclic procedure to ensure proper incorporation of amino acids (AAs) into the growing peptide chain. This method involves the use of a resin, which is a non-soluble, polymer-based material. The large share of this segment can primarily be attributed to the wide range of advantages associated with the use of solid-phase synthesis, such as ease of operation, easy purification, short production cycles, high-level automation, and synthesis capabilities of long peptides in small quantities of amino acids.
Solution-Phase Synthesis
Solution-phase synthesis, or liquid-phase synthesis, is the traditional method of peptide production. It has, however, been replaced in most labs by solid-phase synthesis. SPS is based on the coupling of single amino acids in solutions. SPS is used in the large-scale production of peptides for industrial purposes. The prime advantage of this method is that the intermediate products can be deprotected and purified. Factors such as large quantities of high-quality peptides, easy and inexpensive scale-up, and the procedure being suitable for ligation technologies are supporting the growth of the solution-phase synthesis market.
Hybrid and Recombinant Technology
In hybrid technology, solid and liquid phase synthesis methodologies are used together to synthesize peptides. This approach uses solid phase method on resins, and then the amino acid segments are condensed in solution to construct the full peptide sequence. Factors such as the ability to synthesize peptides with higher complexity or length and biologically active conformation or higher immunogenicity as compared to chemical synthesis are further expected to increase the demand for hybrid and recombinant technologies in the next few years.
Critical questions the report answers:
- Where will all these developments take the industry in the mid to long term?
- What are the major end users and technologies of peptide synthesis?
Lack of unified set of regulations for therapeutic peptides is a major factor restraining the growth of the market. The development of a unified set of regulatory guidelines that can effectively address the safety and quality requirements for a diverse group of molecular entities with various unique mechanisms of action is a challenging task. There are no formal guidelines from any regulatory agency for the development of this class of therapeutics. This lack of a unified set of regulations has made it difficult to secure approvals for therapeutic peptides, which in turn is limiting their application areas. This is considered as a major factor restraining the growth of the global peptide synthesis market.
The prominent players in the peptide synthesis market are GenScript Biotech Corporation (China), AAPPTec (US), Bachem (Switzerland), AnaSpec (US), Biotage (Sweden), CEM Corporation (US), Gyros Protein Technologies (Sweden), Advanced ChemTech (US), Merck KGAA (Germany) and New England Peptide (US). Product launches and agreements, partnerships and collaborations were the major strategies adopted by these payers to maintain their positions in the market.
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Table of Contents
1 Introduction (Page No. - 14)
1.1 Objectives of the Study
1.2 Market Definition
1.3 Market Scope
1.3.1 Markets Covered
1.3.2 Years Considered for the Study
1.4 Currency
1.5 Limitations
1.6 Stakeholders
2 Research Methodology (Page No. - 18)
2.1 Research Data
2.1.1 Secondary Sources
2.1.1.1 Key Data From Secondary Sources
2.1.2 Primary Sources
2.1.2.1 Key Data From Primary Sources
2.2 Market Size Estimation
2.3 Market Breakdown and Data Triangulation
2.4 Market Share Estimation
2.5 Assumptions for the Study
3 Executive Summary (Page No. - 28)
4 Premium Insights (Page No. - 32)
4.1 Peptide Synthesis Market - Overview
4.2 Europe: Market, By Technology & End User (2017)
4.3 Global Market: Geographic Snapshot
4.4 Peptide Synthesis: Geographic Mix
5 Market Overview (Page No. - 36)
5.1 Introduction
5.2 Market Dynamics
5.2.1 Drivers
5.2.1.1 Increasing Use of Peptides in Pharmaceutical Drugs
5.2.1.2 Increase in Research Activities and Availability of Funding for R&D
5.2.1.3 Development of Advanced Peptide Synthesizers
5.2.2 Restraint
5.2.2.1 Lack of A Unified Set of Regulations for Therapeutic Peptides
5.2.3 Opportunitie
5.2.3.1 Emerging Markets in the Asia Pacific Region
5.2.4 Challenge
5.2.4.1 Issues Associated With the Route of Administration of Peptide Drugs
6 Peptide Synthesis Market, By Product (Page No. - 40)
6.1 Introduction
6.2 Reagents
6.3 Equipment
6.3.1 Peptide Synthesizers
6.3.2 Chromatography Equipment
6.3.3 Lyophilizers
7 Peptide Synthesis Market, By Technology (Page No. - 49)
7.1 Introduction
7.2 Solid-Phase Peptide Synthesis (SPPS)
7.3 Solution-Phase Synthesis (SPS)
7.4 Hybrid and Recombinant Technology
8 Peptide Synthesis Market, By End User (Page No. - 55)
8.1 Introduction
8.2 Pharmaceutical and Biotechnology Companies
8.3 Contract Development and Manufacturing Organization/ Contract Research Organization
8.4 Academic and Research Institutes
9 Peptide Synthesis Market, By Region (Page No. - 61)
9.1 Introduction
9.2 North America
9.2.1 US
9.2.2 Canada
9.3 Europe
9.3.1 Germany
9.3.2 UK
9.3.3 France
9.3.4 Italy
9.3.5 Spain
9.3.6 Rest of Europe
9.4 Asia Pacific
9.4.1 China
9.4.2 Japan
9.4.3 India
9.4.4 Rest of Asia Pacific
9.5 Latin America
9.6 Middle East and Africa
10 Competitive Landscape (Page No. - 102)
10.1 Overview
10.2 Competitive Scenario
10.3 Growth Strategy Matrix
10.3.1 Acquisitions
10.3.2 Product Launches
10.3.3 Agreements, Partnerships, and Collaborations
10.3.4 Expansions
11 Company Profiles (Page No. - 106)
(Business Overview, Products Offered, Recent Developments, SWOT Analysis, MnM View)*
11.1 Genscript Biotech
11.2 Merck KGaA
11.3 Aapptec
11.4 Bachem Holdings
11.5 Anaspec (A Subsidiary of Kaneka Eurogentec S.A.)
11.6 Biotage
11.7 CEM Corporation
11.8 Gyros Protein Technologies
11.9 Advanced Chemtech
11.10 NEP (New England Peptide)
*Business Overview, Products Offered, Recent Developments, SWOT Analysis, MnM View Might Not Be Captured in Case of Unlisted Companies.
12 Appendix (Page No. - 128)
12.1 Insights of Industry Experts
12.2 Discussion Guide
12.3 Knowledge Store: Marketsandmarkets Subscription Portal
12.4 Available Customizations
12.5 Related Reports
12.6 Author Details
List of Tables (92 Tables)
Table 1 Peptide Synthesis Market: Impact Analysis of Drivers, Restraints, Opportunities, and Challenges
Table 2 Market, By Product, 20162023 (USD Million)
Table 3 Peptide Synthesis Reagents Market, By Country, 20162023 (USD Million)
Table 4 Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 5 Peptide Synthesis Equipment Market, By Country, 20162023 (USD Million)
Table 6 Major Peptide Synthesizers Available in the Market
Table 7 Peptide Synthesizers Market, By Country, 20162023 (USD Million)
Table 8 Market for Chromatography Equipment, By Country, 20162023 (USD Million)
Table 9 Market for Lyophilizers, By Country, 20162023 (USD Million)
Table 10 Peptide Synthesis Market, By Technology, 20162023 (USD Million)
Table 11 Solid-Phase Peptide Synthesis Market, By Country 20162023 (USD Million)
Table 12 Solution-Phase Synthesis Market, By Country 20162023 (USD Million)
Table 13 Hybrid and Recombinant Peptide Synthesis Market, By Country, 20162023 (USD Million)
Table 14 Market, By End User, 20162023 (USD Million)
Table 15 Market for Pharmaceutical and Biotechnology Companies, By Country, 20162023 (USD Million)
Table 16 Market for Contract Development and Manufacturing Organizations, By Country, 20162023 (USD Million)
Table 17 Market for Academic and Research Institutes, By Country, 20162023 (USD Million)
Table 18 North America: Peptide Synthesis Market, By Country, 20162023 (USD Million)
Table 19 North America: Market, By Product, 20162023 (USD Million)
Table 20 North America: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 21 North America: Market, By Technology, 20162023 (USD Million)
Table 22 North America: Market, By End User, 20162023 (USD Million)
Table 23 US: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 24 US: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 25 US: Market, By Technology, 20162023 (USD Million)
Table 26 US: Market, By End User, 20162023 (USD Million)
Table 27 Canada: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 28 Canada: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 29 Canada: Market, By Technology, 20162023 (USD Million)
Table 30 Canada: Market, By End User, 20162023 (USD Million)
Table 31 Europe: Peptide Synthesis Market, By Country, 20162023 (USD Million)
Table 32 Europe: Market, By Product, 20162023 (USD Million)
Table 33 Europe: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 34 Europe: Market, By Technology, 20162023 (USD Million)
Table 35 Europe: Market, By End User, 20162023 (USD Million)
Table 36 Germany: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 37 Germany: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 38 Germany: Market, By Technology, 20162023 (USD Million)
Table 39 Germany: Market, By End User, 20162023 (USD Million)
Table 40 UK: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 41 UK: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 42 UK: Market, By Technology, 20162023 (USD Million)
Table 43 UK: Market, By End User, 20162023 (USD Million)
Table 44 France: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 45 France: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 46 France: Market, By Technology, 20162023 (USD Million)
Table 47 France: Market, By End User, 20162023 (USD Million)
Table 48 Italy: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 49 Italy: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 50 Italy: Market, By Technology, 20162023 (USD Million)
Table 51 Italy: Market, By End User, 20162023 (USD Million)
Table 52 Spain: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 53 Spain: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 54 Spain: Market, By Technology, 20162023 (USD Million)
Table 55 Spain: Market, By End User, 20162023 (USD Million)
Table 56 RoE: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 57 RoE: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 58 RoE: Market, By Technology, 20162023 (USD Million)
Table 59 RoE: Market, By End User, 20162023 (USD Million)
Table 60 Asia Pacific: Peptide Synthesis Market, By Country, 20162023 (USD Million)
Table 61 Asia Pacific: Market, By Product, 20162023 (USD Million)
Table 62 Asia Pacific: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 63 Asia Pacific: Market, By Technology, 20162023 (USD Million)
Table 64 Asia Pacific: Market, By End User, 20162023 (USD Million)
Table 65 China: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 66 China: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 67 China: Market, By Technology, 20162023 (USD Million)
Table 68 China: Market, By End User, 20162023 (USD Million)
Table 69 Japan: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 70 Japan: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 71 Japan: Market, By Technology, 20162023 (USD Million)
Table 72 Japan: Market, By End User, 20162023 (USD Million)
Table 73 India: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 74 India: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 75 India: Market, By Technology, 20162023 (USD Million)
Table 76 India: Market, By End User, 20162023 (USD Million)
Table 77 RoAPAC: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 78 RoAPAC: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 79 RoAPAC: Market, By Technology, 20162023 (USD Million)
Table 80 RoAPAC: Market, By End User, 20162023 (USD Million)
Table 81 Latin America: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 82 Latin America: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 83 Latin America: Market, By Technology, 20162023 (USD Million)
Table 84 Latin America: Market, By End User, 20162023 (USD Million)
Table 85 Middle East & Africa: Peptide Synthesis Market, By Product, 20162023 (USD Million)
Table 86 Middle East & Africa: Peptide Synthesis Equipment Market, By Type, 20162023 (USD Million)
Table 87 Middle East & Africa: Market, By Technology, 20162023 (USD Million)
Table 88 Middle East & Africa: Market, By End User, 20162023 (USD Million)
Table 89 Key Acquisitions, January 2015 June 2018
Table 90 Key Product Launches, January 2015 June 2018
Table 91 Key Agreements, Partnerships, and Collaborations, January 2015 June 2018
Table 92 Key Expansions, January 2015 June 2018
List of Figures (29 Figures)
Figure 1 Research Design
Figure 2 Primary Sources
Figure 3 Breakdown of Primary Interviews(Supply Side): By Company Type, Designation, and Region
Figure 4 Breakdown of Primary Interviews(Demand Side): By End User, Designation, and Region
Figure 5 Bottom-Up Approach
Figure 6 Top-Down Approach
Figure 7 Data Triangulation Methodology
Figure 8 Peptide Synthesis Market, By Product, 2018 vs 2023 (USD Million)
Figure 9 Global Market, By Technology, 2018 vs 2023 (USD Million)
Figure 10Global Market, By End User, 2018 vs 2023 (USD Million)
Figure 11 Geographical Snapshot of the Global Market
Figure 12 Increasing Use of Peptides in the Pharmaceutical Industry is Driving Market Growth
Figure 13 The Pharmaceutical and Biotechnology Companies Segment Commanded the Largest Share of the Peptide Synthesis Market in 2017
Figure 14 The US Accounted for the Largest Share of the Global Market in 2017
Figure 15 APAC to Register the Highest CAGR During the Forecast Period
Figure 16 Reagents Segment to Dominate the Global Market During the Forecast Period
Figure 17 Solid-Phase Peptide Synthesis to Dominate the Peptide Synthesis Technology Market During the Forecast Period
Figure 18 Peptide Synthesis Market, By End User, 20162023 (USD Million)
Figure 19 Global Market: Geographic Growth Opportunities
Figure 20 Global Market, By Region, 20162023 (USD Million)
Figure 21 North America: Market Snapshot
Figure 22 Europe: Market Snapshot
Figure 23 Asia Pacific: Market Snapshot
Figure 24 Key Developments in the Peptide Synthesis Market Between January 2015 and June 2018
Figure 25 Genscript: Company Snapshot (2017)
Figure 26 Merck KGaA: Company Snapshot (2017)
Figure 27 Bachem Holdings: Company Snapshot (2017)
Figure 28 Kaneka Corporation: Company Snapshot (2017)
Figure 29 Biotage: Company Snapshot (2017)
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Growth opportunities and latent adjacency in Peptide Synthesis Market