Protein A Resin Market by Product (Agarose-based, Glass/Silica-based, Organic polymer-based), Type (Recombinant Protein A, Natural Protein A), Application (Antibody Purification, Immunoprecipitation), End User & Region - Global Forecast to 2028
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The global protein A resin market in terms of revenue was estimated to be worth $1.2 billion in 2022 and is poised to reach $2.1 billion by 2028, growing at a CAGR of 9.8% from 2022 to 2028 The new research study consists of an industry trend analysis of the market. The new research study consists of industry trends, pricing analysis, patent analysis, conference and webinar materials, key stakeholders, and buying behaviour in the market. Growth of the market is attributed to the increased R&D investments in pharmaceutical industries, the growing demand for protein engineered products used in the development of vaccines and therapeutics.
Global protein A resin market Trends
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Protein A resin Market Dynamics
Driver: Increasing demand for therapeutic antibodies
Chromatography is an essential step in the purification of monoclonal antibodies (mAbs). Over the past decade, there has been a tremendous increase in the demand for monoclonal antibodies in oncology and several other therapeutic areas, including neurological, autoimmune, and inflammatory disorders. As a result, almost all major pharmaceutical companies are focusing on the R&D of therapeutic antibodies.
In the purification of monoclonal antibodies, anionic impurities, such as nucleic acids and endotoxins, are removed through chromatography. In drug discovery applications, this process consumes a large number of resins, as the usage is not limited to purification but also includes the study of the ionic interaction of molecules. Impurities such as albumin and transferrin are removed by size-exclusion chromatography (SEC). High levels of purification can be achieved through the use of protein A affinity resins. This is because antibodies selectively bind protein A ligands with the resins. This is expected to drive the demand for protein A resins during the forecast period. In June 2020, UK’s Medicines and Healthcare Products Regulatory Agency planned for new regulations to come into force in 2023. Products that already have conformity markings, either UKCA or CE, will be able to remain in the market after the regulations come into force.
Restraint: High cost of resins
Protein A resins cost around 5–10 times more than other types of resins. Though there are no alternative techniques that can achieve purification levels as high as protein A resins, their high cost makes end users look for alternatives. Some of the techniques that provide acceptable levels of purification include both chromatography and non-chromatography methods. mAb crystallization and precipitation by polyethylene glycol (PEG) precipitation are being explored as alternatives for protein A chromatography.
The impact of this restraining factor is more evident in emerging markets such as the Asia Pacific and Latin America. However, with the entry of new market players, the cost of protein A resins is expected to come down significantly. The increasing pressure on major market players is expected to result in price reduction, as small market entrants are offering resins at far lower prices while simultaneously offering comparable product quality.
Opportunity: Increasing number of CMOs and CROs
An increasing number of CMOs and CROs are offering their services to pharmaceutical companies across the globe. This is expected to offer potential growth opportunities to protein A resin manufacturers during the forecast period.
Pharmaceutical companies are increasingly relying on contract manufacturers in various areas of research to fulfill a number of basic needs, such as specialized competencies and cost reduction. The pharmaceutical contract manufacturing industry has experienced robust growth in recent years, and this trend is expected to continue in the coming years. The increasing pressure from several governments to reduce healthcare costs and declining R&D productivity have compelled core pharmaceutical producers to rely on contract manufacturing. Moreover, the rising demand for generic drugs in China and India is a key driver for CMO sales.
In the biologics sector, the biosimilars market is expected to witness the highest growth. The patent expiry of blockbuster biologics is expected to encourage a number of companies to invest in biosimilars during the forecast period. Chromatography is one of the key bioseparation techniques used in the manufacturing of biosimilar antibodies. The rising demand for biosimilars is thus estimated to increase the use of chromatography resins during the forecast period.
The currently available biosimilars are used to treat cancer, rheumatoid arthritis, infectious diseases, psoriasis, anemia, kidney failure, Type I and Type II diabetes, post-menopausal osteoporosis, and hormonal disorders. The key targeted therapeutic areas for which various biosimilars are in the pipeline include oncology, autoimmune disorders, diabetes, and hepatitis. Besides these, biosimilars can be developed for other chronic disorders, such as meningitis, breast cancer, adult T-cell leukemia, obesity, hypertension, and hepatitis E.
Most of the early biologic drugs lost their patent protection in the first half of the 20th century, while many of the current best-selling drugs will lose their patent protection in the coming years. This is creating new opportunities for biosimilar drugs. For instance, in 2020, the patent of Vyrologix (Leronlimab), prescribed in the treatment of cancer, COVID-19, HIV, and cancer, expired in the US. This is expected to create significant opportunities for lower-priced Vyrologix biosimilars in the US and Europe.
Challenge: Issues associated with scaling up production of protein A resins
The production of protein A resins is a complex process that involves many steps, including fermentation, extraction, purification, and packaging. Scaling up the production process to meet the growing demand requires careful planning and management to ensure consistency and quality throughout the production process.
Scaling up the production process can result in variability in the quality and consistency of the resin. Factors such as changes in the source material, equipment, and personnel can all contribute to this variability. Maintaining consistency in the manufacturing process is essential to ensure the quality of the final product.
By product, the agarose-based protein A resin segment of global protein A resin market, accounted for the largest share during the forecast period.
Based on product, the market is segmented into agarose-based protein A resin, glass/silica based protein a resin and organic polymer based protein A resin. The agarose based protein A resin segment accounts for the largest share of the market. Agarose-based protein A resins exhibit enhanced durability, greater mechanical robustness, and a superior capacity to incorporate metal dopant absorption at pH levels that are appropriate.
By type, the recombinant protein A resin segment of protein A resin market, accounted for the largest share during the forecast period.
Based on type, the market is segmented into recombinant and natural protein A resin. The recombinant protein A resin segment accounts for the largest share of the market. Due to its advanced technological improvements in the drug discovery process, there is a rising need for recombinant protein resins in the pharmaceutical industry. This is because they offer a more targeted binding capacity, which is expected to propel the growth of this segment during the forecast period.
By application type, the antibody purification segment of protein A resin market is expected to witness a significant growth during the forecast period.
Based on application, the market is segmented into Based on application, the protein A resin is segmented into antibody purification, immunoprecipitation. The antibody purification segment is expected to witness a significant growth during the forecast period. The biopharmaceutical and biotechnology industries have facilitated the advancement of immunoprecipitation applications in the R&D sector, leading to its significant growth and dominance in the industry in the upcoming years.
By End User, pharmaceutical & biopharmaceutical companies’ segment of protein A resin market to grow at the fastest rate during the forecast period.
Based on end user, the global market is segmented into pharmaceutical & biopharmaceutical companies, academic and research institutes, other end users. The pharmaceutical and biopharmaceutical companies have facilitated the advancement of immunoprecipitation applications in the R&D sector, leading to its significant growth and dominance in the industry in the upcoming years. Also, the anticipated revenue growth of this segment during the forecast period is attributed to the rapid expansion of the biopharmaceutical industry worldwide and the technological advancements in the pharmaceutical and biotechnology sectors.
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North America is expected to be the largest region of the global protein A resin market during the forecast period.
North America, comprising the US and Canada, held the largest share of the global market. This region is witnessing a surge in demand for protein-based therapeutics to combat infectious diseases, which is further amplified by the growing number of FDA-approved pharmaceutical and biotechnology companies in this region.
As of 2021, prominent players in the market are Danaher Corporation (US), Merck KGAa (Germany), Repligen Corporation (US), Thermo Fisher Scientific (US), Agilent Technologies (US), GenScript (China), PerkinElmer Inc. (US), Bio-Rad Laboratories, Inc. (US), Orochem Technologies Inc. (US), Kaneka Corporation (Japan), Abcam Plc. (UK), Agarose Bead Technologies (US), and Avantor, Inc. (US), among others.
Protein A Resin Market Report Scope:
|
Report Metric |
Details |
|
Market Revenue in 2022 |
$1.2 billion |
|
Projected Revenue by 2028 |
$2.1 billion |
|
Revenue Rate |
poised to grow at a CAGR of 9.8% |
|
Growth Driver |
Increasing demand for therapeutic antibodies |
|
Growth Opportunity |
Increasing number of CMOs and CROs |
This report has segmented the global protein A resin market to forecast revenue and analyze trends in each of the following submarkets:
By product
- Agarose based protein A resin
- Glass/Silica based protein A resin
- Organic polymer based protein A resin
By Type
- Recombinant protein A resin
- Natural protein A resin
By Application
- Antibody Purification
- Immunoprecipitation
By end user
- Pharmaceutical and biopharmaceutical companies
- Academic Research institutes
- Other end users
By Region
-
North America
- US
- Canada
-
Europe
- Germany
- France
- UK
- Italy
- Spain
- Rest of Europe
-
Asia Pacific
- Japan
- China
- India
- Australia
- South Korea
- Rest of Asia Pacific
- Rest of the World
Recent Developments
- In September 2022, As part of its charitable efforts through the Agilent Foundation, Agilent Technologies partnered with Delaware State University (DSU) to boost the number of minority students who choose STEM careers.
- In October 2021, Tosoh Biosciences LLC completed the acquisition of Semba Biosciences, a privately held leading innovator in the field of multi-column chromatography (MCC) instrumentation and technology for the downstream purification of biologics.
- In September 2021, Repligen and Navigo completed their co-development of a novel affinity ligand that addresses aggregation issues associated with pH-sensitive antibodies and Fc-fusion proteins. This ligand, NGL-Impact HipH, is produced and supplied to Purolite for use in a platform usage resin product.
- In May 2021, The Life Sciences business of GE Healthcare was acquired by Danaher Corporation and rebranded as Cytiva.
Frequently Asked Questions (FAQ):
What is the projected market revenue value of the protein A resin market?
The protein A resin market boasts a total revenue value of $2.1 billion by 2028.
What is the estimated growth rate (CAGR) of the protein A resin market?
The global protein A resin market has an estimated compound annual growth rate (CAGR) of 9.8% and a revenue size in the region of $1.2 billion in 2022.
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This study involved the extensive use of both primary and secondary sources. The research process involved the study of various factors affecting the industry to identify the segmentation types, industry trends, key players, competitive landscape, key market dynamics, and key player strategies.
Secondary Research
The secondary research process involves the widespread use of secondary sources, directories, databases (such as Bloomberg Businessweek, Factiva, and D&B Hoovers), white papers, annual reports, company house documents, investor presentations, and SEC filings of companies. Secondary research was used to identify and collect information useful for the extensive, technical, market-oriented, and commercial study of the protein A resin market. It was also used to obtain important information about the key players and market classification & segmentation according to industry trends to the bottom-most level and key developments related to market and technology perspectives. A database of the key industry leaders was also prepared using secondary research.
Primary Research
In the primary research process, various sources from both the supply and demand sides were interviewed to obtain qualitative and quantitative information for this report. The primary sources from the supply side include industry experts such as CEOs, vice presidents, marketing and sales directors, technology & innovation directors, and related key executives from various key companies and organizations in the protein A resin market. The primary sources from the demand side include medical OEMs, Analytical instrument OEMs, CDMOs, and service providers, among others. Primary research was conducted to validate the market segmentation, identify key players in the market, and gather insights on key industry trends & key market dynamics.
A breakdown of the primary respondents is provided below:
*Others include sales managers, marketing managers, business development managers, product managers, distributors, and suppliers.
Note: Companies are classified into tiers based on their total revenue. As of 2021, Tier 1 = >USD 2 billion, Tier 2 = USD 50 million to USD 2 billion, and Tier 3 = <USD 50 million.
To know about the assumptions considered for the study, download the pdf brochure
|
Company Name |
Designation |
|
Tosoh Bioscience LLC |
Application Manager |
|
Cytiva |
Product Sales Specialist |
|
Cytiva |
Product Manager |
Market Estimation Methodology
In this report, the global protein A resin market size was arrived at by using the revenue share analysis of leading players. For this purpose, key players in the market were identified, and their revenues from the protein A resin business were determined through various insights gathered during the primary and secondary research phases. Secondary research included the study of the annual and financial reports of the top market players. In contrast, primary research included extensive interviews with key opinion leaders, such as CEOs, directors, and key marketing executives.
To calculate the global market value, segmental revenues were calculated based on the revenue mapping of major solution/service providers. This process involved the following steps:
- Generating a list of major global players operating in the protein A resin market
- Mapping annual revenues generated by major global players from the protein A resin segment (or nearest reported business unit/product category)
- Revenue mapping of key players to cover major share of the global market, as of 2021
- Extrapolating the global value of the protein A resin industry
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Data Triangulation
After arriving at the overall market size from the market size estimation process explained above, the global protein A resin market was split into segments and subsegments. Data triangulation and market breakdown procedures were employed to complete the overall market engineering process and arrive at the exact statistics for all segments and subsegments. The data was triangulated by studying various factors and trends from both the demand and supply sides. Additionally, the market was validated using both top-down and bottom-up approaches.
Objectives of the Study
- To define, describe, and forecast the protein A resin market on the basis of product, type, application, end user, and region
- To provide detailed information regarding the major factors influencing the growth potential of the global market (drivers, restraints, opportunities, challenges, and trends)
- To analyze the micro markets with respect to individual growth trends, future prospects, and contributions to the global market
- To analyze key growth opportunities in the global market for key stakeholders and provide details of the competitive landscape for market leaders
- To forecast the size of market segments and/or subsegments with respect to five major regions, namely, North America (US and Canada), Europe (Germany, France, the UK, Italy, Spain, and the RoE), Asia Pacific (Japan, China, India, Australia, South Korea, and the RoAPAC), and rest of the world.
- To profile the key players in the global market and comprehensively analyze their market shares and core competencies
- To track and analyze the competitive developments undertaken in the global protein A resin market, such as product launches, agreements, expansions, and & acquisitions
Available Customizations
With the given market data, MarketsandMarkets offers customizations as per the company’s specific needs. The following customization options are available for the present global protein A resin market report:
Product Analysis
- Product matrix, which gives a detailed comparison of the product portfolios of the top fifteen companies
Company Information
- Detailed analysis and profiling of additional market players (up to 15)
Geographic Analysis
- Further breakdown of the Rest of Europe market into Russia, Belgium, the Netherlands, Switzerland, Austria, Finland, Sweden, Poland, and Portugal among other
- Further breakdown of the Rest of Asia Pacific market into Singapore, Taiwan, New Zealand, Philippines, Malaysia, and other APAC countries
- Further breakdown of the Rest of the world market into Latin America, MEA, and Africa
Growth opportunities and latent adjacency in Protein A Resin Market
What are the top 2 use cases of protein A resin market in near future?