Top Companies in the Tangential Flow Filtration

The tangential flow filtration market is projected to reach USD 3.20 billion by 2030 from an estimated value of USD 1.86 billion in 2025, at a CAGR of 11.4% during the forecast period. The key factors driving the growth of this tangential flow filtration market include the rising technological advancements in TFF over standard flow filtration, the increasing R&D expenditure, the growth in pharmaceutical & biotechnology industries, and stringent regulatory requirements. The global demand for monoclonal antibodies (mAbs), recombinant proteins, enzymes, and biosimilars fuels the need for high-performance downstream purification. The increasing focus of key players on product launches is another factor expected to contribute to market growth.

The global tangential flow filtration market is consolidated with leading players contributing to the significant share, including Danaher Corporation (US), Merck KGaA (Germany), Sartorius AG (Germany), Repligen Corporation (US), and Parker Hannifin Corporation (US). The market players have adopted new product launches, acquisitions, agreements, collaborations, and geographical expansions to strengthen their position in the global tangential flow filtration market.

• In June 2024, Merck KGaA invested ~USD 200 million (Euros 180 million) to expand its Life Science distribution center in Schnelldorf, Germany. Also, in August 2023, Sartorius (Germany) and Repligen Corporation (US) launched an integrated bioreactor system combining Repligen’s XCell ATF upstream intensification technology with Sartorius’ Biostat STR bioreactor. This collaboration streamlines the implementation of intensified seed trains and N-1 perfusion processes for biopharmaceutical manufacturers.

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Danaher (US)

Danaher is a leading life sciences & diagnostics innovator providing various products and services for medical, industrial, and commercial applications. With its global presence, Danaher Corporation is constantly involved in facility expansions, acquisitions, and partnerships. For instance, in September 2024, Cytiva opened its first Innovation Hub in South Korea, located at the Songdo Global Biotech Cluster in Incheon. This facility is designed to support local biopharmaceutical companies by providing advanced bioprocessing training, technical support, and early access to new technologies. The hub aims to foster collaboration & accelerate the development of biologics and next-generation therapies in the Asia Pacific region. Additionally, in September 2023, Cytiva expanded its facility by establishing a new Center of Excellence for single-use technologies in Shanghai. This facility is designed to help advance and accelerate the development of novel therapeutics.

Meck KGaA (Germany)

Merck KGaA is one of the leading players in the tangential flow filtration market. Merck Millipore has expanded its position as the most profitable technology and solutions supplier in the TFF industry by offering leading-edge products for biotechnology & pharmaceutical companies and the advancement of cell and gene therapy. With a strong geographic presence, a broad portfolio of tangential flow filtration products, and continuous expansion in developed and developing regions, the company is expected to grow at a high rate in the TFF market during the forecast period. The company has a strong international presence, a vast distribution network, established relationships with research institutions, and biotechnology & pharmaceutical companies worldwide. Due to the growing demand for filtration products, Merck focuses on expanding its presence in emerging markets. This involves establishing partnerships, distribution networks, and manufacturing facilities in the Asia Pacific and Latin America.

Sartorius AG (Germany)

Sartorius provides an extensive range of TFF products for end users such as biopharmaceutical & pharmaceutical companies, CMOs, and CROs. The company has actively engaged in strategic expansion due to increasing product demand. During the past three years, Sartorius increased its geographic presence across China, the UK, South Korea, the US, and France by establishing and expanding manufacturing facilities and customer interaction centers to support the significant global demand for pharmaceutical filtration products. With a strong geographic presence and continuous expansions in developed and developing regions, the company is expected to grow in the TFF market during the forecast period.

Market Ranking

The tangential flow filtration market is consolidated, with five leading players collectively holding >80% of the market share.

Danaher maintains a strong position through a comprehensive portfolio of single-use TFF systems, cassettes, and lab-scale solutions, supported by Cytiva’s bioprocessing platforms, and ongoing investments in automation and scalability. Merck KGaA (MilliporeSigma) holds a significant share with its Pellicon cassettes, Mobius systems, and advanced ultrafiltration membranes, highlighted by robust R&D and an end-to-end bioprocessing approach. Sartorius AG continues to expand its footprint with modular and single-use TFF solutions, including hollow fiber formats, focusing on process intensification, integration, and sustainable manufacturing. Repligen is a specialized leader with its KrosFlo systems and hollow fiber assemblies, offering integrated filtration and automation capabilities suited for continuous and perfusion-based processing. Parker Hannifin, while relatively new to the bioprocessing segment, leverages its expertise in engineered filtration and single-use technologies to serve niche and small-scale applications, particularly through OEM channels.

The other market players contribute less than 20% of the total market share, which is fragmented among regional manufacturers and niche players, competing on cost, customization, and innovation. Market growth is shaped by the increasing adoption of single-use bioprocessing, cell and gene therapy manufacturing, and demand for scalable, high-efficiency filtration platforms.

Related Reports:

Tangential Flow Filtration Market by Product (Single Use Systems, Cassettes, Capsules), Material (PES, PVDF), Technique (Ultrafiltration), Application (Protein, Vaccine, API, Cell Separation), Scale of Operation (R&D), End User - Global Forecast to 2030

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