Market Forecast News: Protein A Resin Industry to Hit $2.0B by 2030
The report "Protein A Resin Market by Product (Bulk Resin, Lab-scale Columns), Source (Recombinant Protein A), Matrix Type (Agarose-Based Protein A), Application (Monoclonal Antibody Purification, FC-Fusion Protein Purification) & End User - Global Forecast to 2030", is projected to reach USD 2.0 billion by 2030 from USD 1.5 billion in 2025, growing at a CAGR of 6.5% during the forecast period.
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The growth of the market is driven by increased outsourced services through CDMO, with major companies expanding multiple biomanufacturing plants in developed markets. The global monoclonal antibody (mAb) pipeline is expanding, propelled by numerous FDA approvals and the launch of new bispecifics and antibody-drug conjugates. This has resulted in higher purification requirements among end users, which is anticipated to boost the market for protein A resin.
“Based on product, bulk resin held the largest share of the protein A resin market in 2024.”
Based on products, the protein A resin market is divided into bulk resin, pre-packed columns, lab-scale columns, and others. Unlike pre-packed formats, bulk resin is the industry standard for high-volume purification processes carried out in stainless-steel column setups. Although it requires in-house packing and validation, bulk resin provides a significantly lower cost per cycle and per gram of purified monoclonal antibody. It is the preferred choice among end users due to its reusability. Most types can support 50 to over 200 cycles, enabling extended production campaigns with minimal resin replacement. This feature directly enhances the economic efficiency and productivity goals of commercial manufacturing. All these factors make bulk resin a favored option in end-use industries, helping it secure a major share of the protein A resin market.
“Based on matrix type, the agarose-based protein A resin segment accounted for the largest share during the forecast period.”
Based on the matrix type, the protein A resin market is segmented into agarose-based protein A resin, glass/silica-based protein A resin, and organic polymer-based protein A resin. The agarose-based protein A resin segment holds the largest market share. These resins exhibit improved durability, increased mechanical strength, and a higher capacity to absorb metal dopants at appropriate pH levels. The growth of agarose-based protein A is driven by the rising global demand for monoclonal antibodies, a greater focus on scalable and cost-effective downstream processing, and the resin’s well-established advantages—such as excellent flow properties, high mechanical strength, and suitability for both traditional and continuous bioprocessing systems.
“Based on application, the monoclonal antibody purification segment has acquired the largest share in 2024.”
Based on applications, the protein A resin market is segmented into monoclonal antibodies purification, FC-fusion proteins purification, and other applications. Monoclonal antibodies (mAbs) purification accounts for the largest share in the protein A resin market due to its established role in large-scale biopharmaceutical manufacturing. mAbs constitute the most extensively produced category of biologic therapeutics, requiring substantial volumes of protein A resin for primary capture steps in downstream processing. Protein A resin is preferred for this purpose owing to its Fc region binding specificity and alignment with regulatory standards for product purity and consistency. Additionally, a significant portion of installed biomanufacturing capacity across pharmaceutical companies and contract manufacturing organizations is dedicated to mAb production, which structurally drives higher demand for protein A resin within this application segment.
“Based on end users, the pharmaceutical and biopharmaceutical companies segment accounted for the largest share in 2024.”
Pharmaceutical and biopharmaceutical companies hold the largest share of the protein A resin market because they are the leading producers of therapeutic proteins, especially monoclonal antibodies (mAbs) and Fc-fusion proteins. These companies operate large-scale production facilities where protein A resin is widely used in downstream purification, requiring substantial resin volumes to meet both commercial demand and regulatory standards. Moreover, their in-house manufacturing setups focus on ensuring consistent supply chains and quality control, encouraging direct procurement of protein A resins rather than relying solely on external suppliers. This heavy dependence on protein A resin for core biologics production makes pharmaceutical and biopharmaceutical companies the leading end-user segment in the market.
“North America held the largest market share for 2024.”
The protein A resin market comprises five key regions: North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. In 2024, North America held a significant market share for protein A resin. This dominant position is due to increased manufacturing capacity and a growing focus on commercial-scale and clinical trial supply production. Investment trends show that U.S. federal and state support encourages domestic biomanufacturing to prepare for pandemics and reduce reliance on international supply chains. Small- to mid-sized biotech firms are increasingly partnering with CDMOs. These factors have helped North America capture the largest market share in 2024.
Major Market Players
The key players in the protein A resin market are Danaher Corporation (US), Repligen Corporation (US), Merck KGaA (Germany), Thermo Fisher Scientific (US), Agilent Technologies (US), GenScript (China), Bio-Rad Laboratories, Inc. (US), Orochem Technologies Inc. (US), Kaneka Corporation (Japan), Abcam Plc. (UK), Ecolab (US), and Tosoh Biosciences LLC (Japan).
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