Market Forecast News: Targeted Protein Degradation Industry to Hit $9.85B by 2035
The report "Targeted Protein Degradation Market by Type [PROTACs (Vepdegestrant, Bavdegalutamide), SERDs (Elacestrant), Molecular Glues (Mezigdomide), LDD, LYTAC/ATAC], Indication (Oncology, Inflammatory), Formulation (Oral), End User - Global Forecast to 2035", is projected to reach USD 9.85 billion by 2035 from USD 0.48 billion in 2025, at a CAGR of 35.4% during the forecast period.
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The targeted protein degradation market is growing, driven by several compelling factors. The increasing prevalence of oncology and neurodegenerative diseases has heightened demand for more selective and effective therapies, which TPDs offer by eliminating rather than inhibiting disease-causing proteins. Rapid advancements in protein degrader modalities such as PROTACs, molecular glues, and LYTACs are expanding the druggable proteome, including targets previously deemed undruggable. Strong investment momentum from pharma giants and biotech startups is accelerating clinical development pipelines, supported by promising early-phase efficacy data. Lastly, growing partnerships and licensing deals between TPD developers and large pharmaceutical companies are reinforcing commercial validation. However, a major restraint is the complexity of E3 ligase biology and limited tissue-specific ligase availability, which poses significant challenges in drug design, safety, and target specificity across diverse therapeutic areas.
The oral formulations segment accounted for the highest share by formulation in the targeted protein degradation market in 2024.
The global targeted protein degradation market is segmented by formulation into two main categories: oral and injections. In 2024, the oral formulations segment holds the highest share in the formulation landscape of the novel TPD market, driven by its favorable pharmacokinetics, patient compliance, and manufacturing scalability. Oral delivery remains the preferred route due to its non-invasive nature and ease of administration, which significantly enhances patient adherence, especially in chronic or long-term treatments. The advancements in medicinal chemistry have enabled the development of orally bioavailable degraders, overcoming early limitations of poor solubility and permeability. Many first-generation PROTACs faced challenges with oral bioavailability due to their large molecular weight and polarity; however, recent innovation in structural optimization has yielded degrader candidates suitable for oral dosing without compromising efficacy. From a commercial perspective, oral formulations offer cost-efficiency in distribution and storage, adding to their attractiveness. Oral TPD candidates in oncology, immunology, and neurology have shown promising clinical progress, reinforcing confidence in this route. As the TPD field matures, oral formulations are expected to dominate clinical pipelines and product launches, setting the standard for patient-friendly, scalable therapeutic solutions. The continued investment in optimizing oral bioavailability across heterobifunctional and molecular glue degraders is anticipated to fuel segment growth.
PROTAC was the fastest-growing segment within the degraders type in 2024.
The PROTACs (PROteolysis TArgeting Chimeras) segment was the fastest-growing within the targeted protein degradation (TPD) market due to their ability to selectively eliminate, rather than inhibit, disease-causing proteins. By leveraging the natural ubiquitin-proteasome system of cells, PROTACs redirect E3 ligases to tag specific proteins for degradation, offering a novel approach to address previously undruggable targets. Unlike conventional inhibitors, PROTACs can achieve greater potency and sustained therapeutic effects, often requiring lower doses and showing potential to overcome resistance mechanisms. This has sparked intense interest from the pharmaceutical industry, leading to a rapidly expanding pipeline with numerous candidates advancing through preclinical and clinical development. Clinical-stage PROTACs like ARV-471, ARV-110, and NX-2127 are being evaluated in oncology, particularly in hormone-driven cancers. Ongoing innovation in linker chemistry, E3 ligase selection, and optimization for oral delivery is driving improvements in drug-like properties. With increasing investments, strategic collaborations, and a broadening scope across therapeutic areas, PROTACs are poised to become a cornerstone of next-generation drug discovery. Their versatility and ability to precisely degrade specific proteins continue to position them as a leading modality within the growing TPD market.
North America accounted for the largest regional share in the targeted protein degradation market in 2024.
The market for targeted protein degradation is divided into six segments: North America, Europe, Asia Pacific, Latin America, the Middle East, and Africa. North America holds the largest share in the targeted protein degradation (TPD) market, driven by strong R&D infrastructure, robust funding ecosystems, and a favorable regulatory environment. The region is home to several pioneering biotechnology and pharmaceutical companies that are leading the development of TPD platforms, particularly PROTACs and molecular glues. Major players such as Arvinas, C4 Therapeutics, and Nurix Therapeutics are headquartered in the US, benefiting from access to top-tier research institutions and a highly skilled scientific workforce. In addition, consistent capital inflow from venture capital firms, public markets, and strategic pharmaceutical partnerships has accelerated innovation and clinical progression of TPD candidates. The US Food and Drug Administration (FDA) has also played a critical role by granting fast track and orphan drug designations to promising TPD candidates, thereby expediting their development and regulatory pathways. Increasing investment in oncology, neurodegenerative diseases, and autoimmune indications, which are the key therapeutic areas for TPDs, will continue to drive demand in the region. Academic-industry collaborations, the presence of large-scale clinical trial networks, and a strong intellectual property framework further enhance the leadership position of North America. These combined factors position the region to achieve the highest growth trajectory in the global TPD market.
Key players in the targeted protein degradation market include Bristol Myers Squibb (US), Arvinas (US), BeiGene (US), Nurix (US), Kymera (US), C4 Therapeutics (US), Stemline Therapeutics (US), AstraZeneca (UK), F. Hoffmann-La Roche Ltd (Switzerland), Bayer (Vividion) (Germany), Captor Therapeutics (Poland), Ranok Therapeutics (US), Pfizer (US), Novartis (Switzerland), and Foghorn Therapeutics (US).
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