Top Companies in the Endoscopic Submucosal Dissection

The endoscopic submucosal dissection market (ESD) is projected to reach USD 0.75 billion by 2030 from USD 0.50 billion in 2025, at a CAGR of 8.4% during the forecast period. The increasing occurrence of early-stage gastrointestinal (GI) cancers—especially gastric, colorectal, and esophageal cancers—is significantly driving growth in the endoscopic submucosal dissection (ESD) market. Improvements in widespread screening programs, enhanced imaging technologies, and greater public awareness have contributed to a rise in the diagnosis of precancerous lesions and superficial tumors. These early-stage cancers are typically confined to the mucosal or submucosal layers, making them suitable candidates for minimally invasive procedures like ESD.

Unlike traditional endoscopic techniques, ESD permits en bloc resection of lesions, ensuring complete removal with clear margins for precise histopathological evaluation, which is essential for effective treatment. Additionally, ESD minimizes the need for more invasive surgical options, which often have higher rates of complications and longer recovery times. As healthcare providers become more inclined toward organ-preserving treatments when appropriate, the clinical preference for ESD is on the rise. This trend is particularly prominent in countries with robust cancer screening programs, such as Japan and South Korea, and is increasingly being seen in Europe and the US.

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The key players in the endoscopic submucosal dissection market include Olympus Corporation (Japan), FUJIFILM Holdings Corporation (Japan), Medtronic (Ireland), Boston Scientific Corporation (US), Sumitomo Bakelite Co., Ltd. (Japan), Creo Medical Group Plc (UK), HOYA Corporation (Japan), ConMed Corporation (US), STERIS (Ireland), MTW Endoskopie Manufaktur (Germany), Ovesco Endoscopy AG (Germany), Zeon Medical Inc. (Japan), Micro-Tech Endoscopy (China), Karl Storz SE & CO. KG (Germany), Cook Medical (US), Leo Medical Co., Ltd. (China), Erbe Elektromedizin GmbH (Germany), Taewoong Medical Co., Ltd. (South Korea), DCC Healthcare Limited (Ireland), Kossen Co., Ltd. (South Korea), INNOVAMEDICA S.p.A. (Italy), Jiangsu Vedkang Medical Science and Technology Co., Ltd. (China), Hangzhou AGS Medical Technological Co., Ltd. (China), Beijing ZKSK Technology Co., Ltd. (China), and Upex-Med Co. Ltd. (South Korea). These companies have employed various growth strategies, including product launches, acquisitions, and expansion efforts, to enhance their presence and reach in the endoscopic submucosal dissection market.

Olympus Corporation (Japan) is a leading player in the endoscopic submucosal dissection market. The company's broad and comprehensive product portfolio related to endoscopy equipment is one of its key strengths. Olympus offers a variety of electrosurgical knives for endoscopic submucosal dissection procedures, including the DualKnife, FlexKnife, and HookKnife. The company invests a significant portion of its revenue in research and development to launch technologically advanced products. In 2024, Olympus's total R&D expenditure was USD 687.1 million, an increase from USD 616.1 million in 2023.

FUJIFILM Holdings Corporation (Japan) is a well-established brand in the endoscopic submucosal dissection market, with operations spanning worldwide. It offers a diverse range of endoscopic devices used for examinations related to esophageal, colorectal, and gastric cancer. The main end users of these products include hospitals, medical facilities, and research organizations. The company aims to maintain its brand value by expanding its geographic presence and promoting technological advancements, ensuring it remains a reliable provider of high-quality products.

Medtronic (Ireland) is a medical technology company that manufactures, designs, develops, and markets a broad range of solutions and medical devices for treating cardiac, spinal, neurological, vascular, and chronic conditions. The company also offers endoscopy products through its Respiratory, Gastrointestinal, and Renal business segment, which focuses on creating physician- and patient-centric solutions. Medtronic operates in over 150 countries worldwide.

Market Ranking

The endoscopic submucosal dissection (ESD) market has a concentrated competitive landscape, with a few key players holding the majority of global market share due to their established positions in advanced endoscopic procedures. Market rankings are influenced by factors such as the integration of products within ESD toolkits, procedural success rates, adoption in high-volume regions, support for clinical training, and technological innovation.

Japan and South Korea are at the forefront of global ESD adoption, setting trends and establishing procedural benchmarks. This is followed by increasing adoption in Europe and the US, where regulatory support and reimbursement frameworks are evolving. Companies that offer a comprehensive range of ESD tools—including knives, electrosurgical units, injection needles, and endoscopes—are ranked higher for their ability to provide complete procedural solutions.

Market leaders distinguish themselves through investments in surgeon training programs, clinical studies, and localized distribution. Overall, the ESD market ranking is determined by procedural utility, regional penetration, innovation, and integration across therapeutic endoscopy platforms. Based on this analysis, the leading players in the ESD market include Olympus Corporation (Japan), FUJIFILM Holdings Corporation (Japan), and Medtronic (Ireland). These companies maintain a competitive edge through continuous product development, strategic acquisitions, and strong distribution networks across major healthcare markets.

Related Reports:

Endoscopic Submucosal Dissection Market by Product (Gastroscopes & Endoscopes, Injection Agent, Tissue Retractor), Indication (Stomach Cancer, Colon Cancer), End User (Hospitals, Specialty Clinics, Ambulatory Surgical Center) - Global Forecast to 2030

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