The human microbiome market is projected to reach USD 1,370 million by 2029 from USD 269 million in 2023, at a CAGR of 31.1% from 2023 to 2029. The major factor driving the growth of the human microbiome market is the increasing focus on human microbiome therapy development. The human microbiome as a validated target for drug development & development of human microbiome-based tests for early disease detection and diagnosis are also factors expected to support market growth. Increasing collaborations between private-public organizations are expected to provide significant growth opportunities for players in the human microbiome market. Increasing gastrointestinal disorders, technological advancements, rising investments in human microbiome projects in developing countries, and lucrative presence of market players across the globe are factors responsible for the rapid expansion of global human microbiome market.
The major players in the human microbiome market include Enterome Bioscience (France), Seres Therapeutics (US), 4D Pharma (UK), and Ferring Pharmaceuticals (Switzerland). Various growth strategies have been adopted by these players, such as agreements, collaborations, partnerships, and acquisitions to increase their presence in the global human microbiome market.
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Enterome Bioscience (France) is a clinical-stage biopharmaceutical company focused on the development of innovative therapies to treat microbiome-associated diseases with a focus on IBDs, Crohn’s, and cancer (glioblastoma, colon, pancreatic, lung, and breast) indications. To sustain its position in the human microbiome market, ENTEROME adopts various organic and inorganic growth strategies. The company has been consistently entering into agreements and partnerships with strong biopharmaceutical players, which will help it to expedite drug development for cancer and GI disorders. In 2021, the company raised USD 113.5 million (EUR 96 million) in a Series D financing, which will be used for clinical trials of Enterome’s lead development programs. Moreover, the company received, in non-dilutive cash from collaborations, a facility worth of USD 92.2 million (EUR 78 million) to support the acceleration of its pipeline and technology development. Additionally in 2020, the company received funds of USD 52.6 million from investors, including SymBiosis, LLC (US), a microbiome-focused investment vehicle, and Takeda Pharmaceutical Company Limited (Japan) for the progress of clinical development of its therapeutic pipeline. This pipeline includes the first clinical trials of EO2401, a novel OncoMimic cancer immunotherapy.
R&D Capabilities: The company conducts fundraising rounds to create funding for its various projects to expand its presence human microbiome market. Since its establishment in 2012, the company has raised close to USD 121 million (EUR 100 million) in financing rounds with private equity funds (and strategic investors) and in loans.
Seres Therapeutics (US) is one of the emerging players operating in this market. The company is engaged in developing a range of novel therapeutic products based on the human microbiome. To sustain its position in the human microbiome market, Seres Therapeutics focuses on its products offered for the market. The company’s microbiome therapeutics platform allows to significantly reduces the time typically required to advance therapeutics to the clinic, and ultimately, to the market. The company’s SER-109 program for the treatment of recurrent C difficile infection is anticipated to be the first-ever FDA-approved microbiome therapy. This has helped the company to strengthen its market position in high-growth niche opportunities.
R&D Capabilities: Seres Therapeutics focuses on collaborations to expand its market position in the human microbiome market. In March 2019, Seres collaborated with AstraZeneca to advance the mechanistic understanding of the microbiome in augmenting the efficacy of cancer immunotherapy. Under the agreement, AstraZeneca will pay the company a total of USD 20,000 in three equal instalments. Such financing will help the company to conduct research on its microbiome-based products.
COVID-19 Impact: The company reported revenues of USD 6.05 billion in the second quarter of 2020, which was lower than its reported revenue in the second quarter of 2019. The COVID-19 pandemic adversely impacted the company’s business, including preclinical studies and clinical trials.
Human Microbiome Market by Product (Prebiotics, Probiotics, Food, Diagnostic Tests, Drugs), Application (Therapeutic, Diagnostic), Disease (Infectious, Metabolic/Endocrine), Research Technology (Genomics, Proteomics, Metabolomics) - Global Forecast to 2029
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