The global in vivo toxicology market size is projected to reach USD 6.6 billion by 2025 from USD 5.0 billion in 2020, at a CAGR of 5.5% during the forecast period. Market growth is driven largely by the increasing pharmaceutical R&D activities, innovations in animal models, the development of exclusive in vivo toxicology tests, and the increasing demand for personalized medicine.
The major players operating in this market are by Charles River Laboratories (US), The Jackson Laboratory (US), Envigo (US), Taconic Biosciences, Inc. (US), and JANVIER LABS (France), Thermo Fisher Scientific (US), Danaher Corporation (US), Waters Corporation (US), Agilent Technologies (US), Shimadzu Corporation (Japan), Bruker Corporation (US), PerkinElmer (US). Other prominent players include Merck KGaA (Germany), GE Healthcare (US), and Bio-Rad Laboratories (US), genOway (France), Cyagen Biosciences (US), GVK BIO (India), PolyGene (Switzerland), Crown Biosciences (US), TransCure bioServices (France), Ozgene Pty Ltd. (Australia), Harbour BioMed (US) among others.
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Charles River Laboratories International, Inc. (US)
Charles River has extensive portfolio of animal models, particularly mice models and services. With more than 70 years of experience, the company has built upon its core competency in the field of in vivo biology through its diverse products and services portfolio. It offers products, services, and solutions that focus specifically on early-stage drug discovery and preclinical development. Its strong portfolio enables it to increase collaboration with clients, from early lead generation to candidate selection. Charles River Laboratories has nearly 90 facilities spread across 20 countries. The company has its presence in the US, Canada, the UK, France, Italy, Spain, the Netherlands, Belgium, Germany, Poland, Ireland, Finland, Luxembourg, Japan, China, India, South Korea, Hong Kong, and Australia.
The Jackson Laboratory (US)
The Jackson Laboratory has a portfolio of over 11,000 mice strains. In 2019, the company distributed 3 million JAX mice to approximately 1,400 organizations in 50 countries. The company not only acts as a distributor but also focuses on in-house innovative mice model development. For instance, in February 2020, the company launched the unique K18-hACE2 transgenic mouse model for coronavirus research. The company is utilizing state-of-the-art breeding techniques to grow a new K18-hACE2 transgenic mouse colony rapidly. The company has received many grants, which supports the development of its mice model business. Over the last few years, the company has received grants/funds from leading health organizations and academic institutes such as the National Cancer Institute (NCI), National Institutes of Health (NIH), The Mark Foundation for Cancer Research, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke, and Howard Hughes Medical Institute (HHMI) (US), among others. These grants have helped the company to develop new models, conduct specific studies on the models, compile genome-scale datasets for mice and humans, and examine various patterns of gene expression in mice to gain a better understanding of the genetic programs responsible for normal development and disease.
The company has built upon its core competency in preclinical and non-clinical contract research, research models and services, and animal care products. It offers a wide range of rodent models and services. Envigo has a strong focus on the developing Asian market. Harlan Laboratories (now a part of Envigo) was the first international player to enter the Indian mice model and services market. This has helped the company to establish relationships with several leading life sciences researchers in India, including pharmaceutical, biotechnology, and biopharmaceutical companies, CROs, and private and government research institutes. In January 2014, Harlan Laboratories expanded its presence in India with the introduction of a new research model breeding facility located in Hyderabad, thereby helping it to better serve the company’s current customers.
In Vivo Toxicology Market by Product (Animal Models, Reagents & Kits), Test Type (Chronic, Sub-acute), Toxicity Endpoints (Systemic, Immunotoxicity), Testing Facility (Outsourced, In-house), End User (Academic & Research Institute, CROs) - Forecast to 2025
Mr. Aashish Mehra
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