25 Leading Epigenetics Companies Shaping Innovation and Market Growth to 2030

Discover the top 25 companies driving innovation in the Epigenetics market. This in-depth analysis explores competitive advantages, transformative trends, and key players poised to influence global epigenomics research, drug discovery, and clinical diagnostics through 2030. Access the comprehensive market research report at MarketsandMarkets for further insights.

Spotlights on the Industry's Top Epigenetics Companies

The global epigenetics market is advancing at a compelling pace, driven by deepening scientific understanding of how DNA methylation, histone modification, chromatin remodeling, and non-coding RNA regulation govern gene expression across development, aging, and disease—and the rapidly expanding recognition that these mechanisms represent both powerful diagnostic biomarkers and tractable drug targets for cancer, neurological disorders, cardiovascular disease, and metabolic conditions. Valued at USD 2.03 billion in 2024 and reaching USD 2.24 billion in 2025, the global epigenetics market is projected to grow at a CAGR of 13.9% to reach USD 4.29 billion by 2030. This exceptional growth trajectory reflects surging investment in epigenetics-based drug discovery and clinical diagnostics, the maturation of sequencing and mass spectrometry technologies that make genome-wide epigenome profiling increasingly practical and cost-effective, and the growing appreciation that epigenetic mechanisms provide a critical explanatory layer connecting genetic variation to phenotypic outcomes in complex diseases. In this dynamic environment, the following 25 industry leaders stand out for their scientific innovation, technological contribution, and strategic positioning across the epigenetics research tools, services, and applications landscape.

1. Thermo Fisher Scientific Inc.

Thermo Fisher Scientific Inc. is the dominant commercial force in the epigenetics market, offering an unrivaled portfolio spanning chromatin immunoprecipitation kits, bisulfite conversion reagents, methylation-specific PCR assays, histone modification antibodies, DNA methylation arrays, and epigenome-wide sequencing library preparation solutions that collectively underpin the majority of epigenetics research workflows in laboratories worldwide. Their Invitrogen and Applied Biosystems brands supply the foundational molecular tools—from MethylEdge bisulfite conversion kits to ChIP-grade antibodies and Ion AmpliSeq methylation panels—that researchers rely on from sample preparation through data generation. Thermo Fisher's vertically integrated supply chain, global customer relationships across academic, pharmaceutical, and clinical research, and continuous investment in next-generation epigenomics technologies ensure their sustained leadership at every stage of the epigenetics research and diagnostics workflow.

2. Illumina, Inc.

Illumina, Inc. is the sequencing platform of choice for the vast majority of epigenomics research globally, with its short-read sequencing technology enabling whole genome bisulfite sequencing, reduced representation bisulfite sequencing, ChIP-seq, ATAC-seq, and CUT&RUN workflows that have defined the modern landscape of epigenome profiling. Their EPIC v2 methylation array—interrogating over 900,000 CpG sites across the human genome—has become the gold standard for large-scale DNA methylation studies in population epigenomics, clinical biomarker discovery, and aging research. Illumina's continuous investment in sequencing throughput, read quality, and integrated bioinformatics tools for epigenomics data analysis, combined with their dominant installed base, ensures their central role in the global epigenetics research ecosystem for years to come.

3. Merck KGaA

Merck KGaA contributes extensively to the epigenetics market through its MilliporeSigma brand, which supplies a comprehensive catalog of epigenetics research tools including histone modification antibodies, chromatin remodeling enzyme assays, DNMT and HDAC inhibitor compounds, methylated DNA immunoprecipitation kits, and EpiTect bisulfite conversion reagents that are widely used in academic and pharmaceutical epigenetics research. Their EpiQuik and EpiTect product lines offer streamlined, validated workflows for DNA methylation analysis, histone modification profiling, and chromatin accessibility studies across diverse biological sample types. Merck KGaA's deep commitment to epigenetics research tools, broad chemical and biological reagent catalog, and growing investment in epigenetics-focused drug discovery compounds position them as one of the most comprehensive single-source epigenetics research suppliers in the global market.

4. PacBio

PacBio has emerged as a uniquely important contributor to the epigenetics field through its Single Molecule, Real-Time (SMRT) sequencing technology, which natively detects DNA base modifications—including 5-methylcytosine, 5-hydroxymethylcytosine, and N6-methyladenine—directly from sequencing kinetics without the need for bisulfite conversion or chemical enrichment that can degrade DNA and introduce sequencing artifacts. Their Revio platform's combination of ultra-long reads and simultaneous methylation detection enables researchers to phase epigenetic modifications in their full genomic context, resolve allele-specific methylation patterns, and characterize epigenetic variation across structurally complex genomic regions inaccessible to short-read methods. PacBio's native epigenome sequencing capability represents a fundamental technical advance that is enabling new classes of epigenetics research and clinical epigenomics discovery.

5. Danaher

Danaher participates in the epigenetics market primarily through its Integrated DNA Technologies (IDT) subsidiary, which supplies custom RNA probes, antisense oligonucleotides, CRISPR epigenome editing reagents, and xGen target enrichment panels widely used in epigenome capture sequencing workflows, as well as its Leica Biosystems brand whose tissue imaging and spatial biology platforms support immunohistochemical detection of epigenetic marks including histone modifications and DNA methylation in fixed tissue sections. IDT's expertise in oligonucleotide chemistry and their growing portfolio of epigenome-targeted CRISPR tools—including dCas9-based epigenome editors—support both research and therapeutic development applications in the expanding field of epigenome editing. Danaher's combined portfolio of nucleic acid synthesis, sequencing library preparation, and tissue-based detection capabilities makes them a multi-dimensional contributor to the global epigenetics research ecosystem.

6. Bio-Rad Laboratories, Inc.

Bio-Rad Laboratories, Inc. contributes to the epigenetics market through its digital droplet PCR technology, which enables highly sensitive and precise quantification of methylated DNA fractions from clinical samples in applications including liquid biopsy, cancer epigenomics, and imprinting disorder diagnostics where rare methylated allele detection from complex biological backgrounds is required. Their QX600 Droplet Digital PCR system's ability to measure absolute methylated DNA quantities at sensitivities unachievable by conventional qPCR or pyrosequencing supports emerging clinical epigenomics applications in non-invasive prenatal testing, cancer early detection, and methylation biomarker validation studies. Bio-Rad's longstanding reputation for precision nucleic acid quantification, combined with their growing portfolio of methylation-specific ddPCR assays and reagents, positions them as a technically differentiated contributor to quantitative epigenetics applications.

7. Active Motif

Active Motif is a specialized epigenetics research tools company whose comprehensive portfolio of ChIP-grade antibodies, chromatin immunoprecipitation kits, ATAC-seq reagents, histone modification assays, and epigenome profiling services makes them one of the most focused and respected specialist suppliers in the global epigenetics research market. Their Auto-ChIP automation system and CUT&RUN reagent kits have been adopted by leading epigenomics laboratories as practical solutions for generating high-quality chromatin profiling data from low cell numbers and challenging primary cell types. Active Motif's deep scientific specialization in chromatin biology, extensive antibody validation data, and growing portfolio of epigenome mapping services position them as a trusted and scientifically rigorous partner for researchers at the forefront of chromatin and histone modification biology.

8. New England Biolabs

New England Biolabs (NEB) is a globally trusted enzyme and molecular biology reagent supplier whose epigenetics portfolio encompasses NEBNext enzymatic methyl-seq library preparation kits, DNA methyltransferase and demethylase enzymes, restriction enzyme-based methylation analysis tools, and CpG methyltransferase reagents that support a wide range of DNA methylation analysis and epigenome sequencing workflows. Their NEBNext Enzymatic Methyl-seq (EM-seq) technology—which uses enzymatic conversion of unmodified cytosines rather than harsh bisulfite chemistry—preserves DNA integrity and improves sequencing library quality, making it an increasingly preferred alternative to conventional bisulfite sequencing for whole-genome and targeted methylation profiling. NEB's unwavering commitment to enzyme quality, lot-to-lot consistency, and transparent technical documentation sustains their exceptional reputation among epigenetics researchers who depend on reliable enzymatic performance for reproducible results.

9. QIAGEN

QIAGEN N.V. is a critical enabler of epigenetics research through its EpiTect bisulfite conversion kit—the global standard for DNA methylation analysis sample preparation—as well as its PyroMark pyrosequencing platforms for quantitative methylation analysis, QIAamp circulating nucleic acid kits for liquid biopsy methylation studies, and QIAseq targeted DNA methylation panels for next-generation sequencing-based methylation profiling. Their comprehensive methylation analysis workflow—from DNA extraction and bisulfite conversion through methylation-specific PCR and pyrosequencing quantification—provides researchers and clinical laboratory scientists with a validated, end-to-end solution for DNA methylation measurement from diverse biological sample types. QIAGEN's deep expertise in nucleic acid sample quality, extensive clinical market reach, and growing menu of validated methylation assay products position them as an essential workflow partner for translational epigenomics and clinical epigenetics applications.

10. Zymo Research Corporation

Zymo Research Corporation occupies a uniquely specialized and scientifically influential position in the epigenetics market as the leading supplier of bisulfite conversion reagents, 5-methylcytosine and 5-hydroxymethylcytosine enrichment tools, DNA methylation quantification assays, and epigenomics reference standards whose EZ DNA Methylation Kit has become the most widely cited bisulfite conversion product in the published epigenetics literature. Their proprietary Pico Methyl-Seq and RRBS library preparation kits enable sensitive methylome profiling from ultra-low DNA inputs including single cells and liquid biopsy specimens, while their ZymoBIOMICS methylation standards support rigorous quality control in clinical and research epigenomics programs. Zymo Research's singular scientific focus on DNA methylation chemistry, combined with their track record of methodological innovation that has repeatedly advanced the technical frontiers of methylation analysis, establishes them as the most specialized and scientifically distinguished epigenetics tools company in the global market.

11. Revvity

Revvity, Inc., formerly PerkinElmer's life sciences division, contributes to the epigenetics market through its AlphaLISA and LANCE epigenetic assay platforms, automated high-content imaging systems for histone modification analysis, and genomics reagents that support high-throughput epigenetic drug discovery screening in pharmaceutical research organizations. Their homogeneous AlphaLISA histone modification assay panels enable quantitative, bead-based detection of histone methylation, acetylation, and phosphorylation marks in cell-based and biochemical formats ideally suited to HTS workflows in epigenetics drug discovery programs targeting HDAC, DNMT, HAT, and histone methyltransferase enzymes. Revvity's combination of HTS-compatible epigenetic assay platforms, high-content imaging capabilities, and established pharmaceutical screening customer relationships positions them as an important contributor to the growing pharmaceutical investment in epigenetics-targeted drug discovery.

12. Hologic, Inc.

Hologic, Inc. participates in the epigenetics market through its ThinPrep cervical cytology platform and expanding molecular diagnostics capabilities that intersect with clinical epigenomics in cervical cancer screening, where DNA methylation biomarkers are emerging as important triage tools for identifying women with clinically significant HPV-related cervical disease. Their investment in molecular markers and liquid-based cytology integration creates a foundation for clinical epigenomics-based diagnostic enhancement in the large cervical cancer screening market. Hologic's strong clinical diagnostics infrastructure, regulatory expertise, and established gynecologic oncology market relationships position them to capitalize on the growing clinical evidence supporting DNA methylation biomarkers as adjunctive tools in cervical disease management and cancer prevention programs.

13. F. Hoffmann-La Roche Ltd.

1. Hoffmann-La Roche Ltd. engages with the epigenetics market through its cobas and AVENIO molecular diagnostics platforms, oncology companion diagnostic development programs, and pharmaceutical research into epigenetic mechanisms of cancer and other diseases. Their COBAS EGFR mutation test and expanding liquid biopsy platform development programs increasingly incorporate methylation-based biomarker detection as epigenetic signatures gain clinical traction in cancer detection, treatment selection, and residual disease monitoring. Roche's unique dual identity as a global pharmaceutical innovator and in vitro diagnostics leader creates compelling synergies for translating epigenetics research findings into clinically validated, companion-diagnostic-supported therapeutic applications in oncology and other disease areas where epigenetic dysregulation is a key pathological mechanism.

14. Promega Corporation

Promega Corporation contributes to the epigenetics market through its methylation analysis reagents, histone modification detection assays, bioluminescent cell-based epigenetics reporter systems, and nucleic acid purification tools that support fundamental epigenetics research and drug discovery workflows in academic and pharmaceutical laboratories. Their CpG methyltransferase enzymes, methylation-sensitive restriction enzymes, and Methyl-Profiler DNA methylation PCR systems provide researchers with practical tools for site-specific and genome-wide methylation analysis. Promega's reputation for high-quality enzymes, cellular assay development innovation, and strong academic research customer relationships supports their growing contribution to the epigenetics tools market as interest in functional epigenomics and epigenetic drug discovery continues to expand.

15. EpiGentek Group Inc.

EpiGentek Group Inc. is a dedicated epigenetics research tools and services company offering one of the most comprehensive and specialized catalogs of epigenetics-specific ELISA-based quantification kits, ChIP-grade antibodies, DNA methylation analysis kits, histone acetyltransferase and deacetylase activity assays, and custom epigenomics profiling services available from a single specialist supplier. Their colorimetric and fluorometric epigenetics assay kits—designed for rapid, equipment-accessible quantification of global and locus-specific DNA methylation, histone modification levels, and chromatin modifying enzyme activities—are widely used in laboratories seeking practical, cost-effective epigenomics measurements without access to specialized sequencing or mass spectrometry infrastructure. EpiGentek's singular focus on the epigenetics tools market, extensive validated product portfolio, and responsive technical support make them a highly valued specialist supplier in the global epigenetics research community.

16. EpiCypher

EpiCypher is a chromatin biology tools company that has developed SNAP-ChIP spike-in controls, nucleosome substrates, and dCypher chromatin reader domain screening platforms that address fundamental reproducibility and quantification challenges in histone modification ChIP-seq and chromatin interaction studies. Their designer nucleosome panels and CUTANA CUT&RUN and CUT&TAG reagent kits have been rapidly adopted by leading chromatin biology laboratories as technically superior alternatives to conventional ChIP protocols that offer improved sensitivity, quantification, and reproducibility from low cell inputs. EpiCypher's innovative approach to solving methodological rigor challenges in chromatin biology—combined with their focus on enabling translational epigenomics research and their growing chromatin reader assay platform for epigenetics drug discovery—positions them as a scientifically distinctive and rapidly growing specialist innovator in the epigenetics tools market.

17. Fios Genomics

Fios Genomics is a UK-based bioinformatics and genomics data analysis company specializing in epigenomics data analysis services, including WGBS, RRBS, ChIP-seq, ATAC-seq, and single-cell epigenomics computational analysis pipelines for pharmaceutical, biotech, and academic research clients. Their expert bioinformatics team delivers high-quality, publication-ready epigenome analysis results and biological interpretation services that address the growing demand for specialized computational expertise required to extract meaningful biological insights from the complex multi-dimensional data generated by modern epigenomics experiments. Fios Genomics' scientific depth in epigenomics data analysis, regulatory-grade analysis capabilities for pharmaceutical clients, and collaborative research partnership model position them as a valued specialist analytical partner in the epigenetics services market.

18. GenomeScan

GenomeScan is a Netherlands-based genomics services company offering a comprehensive range of epigenomics services including whole genome bisulfite sequencing, RRBS, EPIC methylation arrays, ChIP-seq, and ATAC-seq to academic and pharmaceutical research clients across Europe and globally. Their ISO 17025-accredited laboratory operations and deep expertise in Illumina-based epigenomics sequencing workflows deliver consistently high-quality epigenome profiling data supported by rigorous quality control and comprehensive bioinformatics analysis. GenomeScan's commitment to laboratory quality standards, European regulatory compliance expertise, and responsive project management make them a trusted epigenomics services partner for pharmaceutical and academic researchers requiring reliable, high-quality methylome and chromatin accessibility data.

19. Creative Biogene

Creative Biogene is a global life science services company offering a broad portfolio of epigenomics services including whole genome bisulfite sequencing, ChIP-seq, ATAC-seq, histone modification profiling, and single-cell epigenomics for research clients across academia, pharmaceutical development, and agricultural biotechnology. Their competitive service pricing, breadth of epigenomics platform coverage, and growing bioinformatics infrastructure support research clients seeking accessible, high-quality epigenome analysis services without the capital investment required to build in-house sequencing and computational infrastructure. Creative Biogene's expanding epigenomics service menu and increasingly sophisticated bioinformatics capabilities reflect the rapid growth in demand for outsourced epigenomics profiling across the global life science research community.

20. BPS Bioscience, Inc.

BPS Bioscience, Inc. is a US-based biochemical reagents and assay company with a strong epigenetics focus, offering a specialized catalog of recombinant histone methyltransferases, demethylases, acetyltransferases, deacetylases, and bromodomain and chromodomain proteins, as well as epigenetics enzyme activity assay kits and chromatin-related binding assays designed to support epigenetics drug discovery and basic research in academic and pharmaceutical laboratory settings. Their extensive portfolio of recombinant epigenetic enzyme targets and validated activity assay formats enables pharmaceutical researchers to screen compound libraries against relevant epigenetic targets and characterize inhibitor potency and selectivity in biochemical assay formats. BPS Bioscience's deep biochemical expertise in epigenetic enzyme biology and their focus on providing well-characterized, research-grade tools for the epigenetics drug discovery community distinguish them as a valued specialist supplier in this scientifically demanding market segment.

21. Abnova Corporation

Abnova Corporation is a Taiwan-based life science reagents company with a growing epigenetics portfolio spanning 5-methylcytosine detection antibodies, histone modification antibodies, methyl-CpG binding domain proteins, DNA methylation ELISA kits, and chromatin-related recombinant proteins that support epigenetics research in academic and pharmaceutical laboratory environments. Their broad antibody catalog, competitive pricing, and accessible global distribution support life science researchers seeking reliable epigenetics detection reagents for immunofluorescence, immunohistochemistry, flow cytometry, and Western blot applications. Abnova's manufacturing scale, diverse epigenetics product catalog, and growing international customer base support their development as a practical and accessible reagent source for the expanding global epigenetics research community.

22. Creative Diagnostics

Creative Diagnostics is a life science reagents and assay development company offering a range of epigenetics-related antibodies, ELISA kits for DNA methylation and histone modification quantification, and custom assay development services that support research and early-stage diagnostic development in the epigenomics field. Their catalog of methylation-specific antibodies, histone modification detection reagents, and quantification assay kits provides accessible epigenomics measurement tools to research laboratories seeking practical solutions for epigenetic biomarker studies. Creative Diagnostics' combination of commercial reagent breadth, custom assay development flexibility, and competitive pricing supports their role as an accessible supplier serving the broad research demand for epigenetics detection and quantification tools.

23. Biomodal

Biomodal is a UK-based genomics technology company that has developed duet technology—a revolutionary dual-base sequencing method that simultaneously sequences DNA and detects 5-methylcytosine and 5-hydroxymethylcytosine from the same sequencing run without bisulfite conversion, preserving DNA integrity and enabling simultaneous genetic and epigenetic profiling from a single library preparation. Their approach addresses one of the most significant technical limitations of conventional bisulfite sequencing—the inability to distinguish between 5mC and 5hmC, and the DNA degradation inherent to bisulfite treatment—by using enzymatic and chemical differentiation strategies compatible with standard sequencing platforms. Biomodal's innovative dual-base sequencing chemistry represents a potential paradigm shift in clinical and research epigenomics, enabling more comprehensive, information-rich, and DNA-preserving epigenome profiling with immediate relevance to liquid biopsy cancer diagnostics and population epigenomics research.

24. Integrated DNA Technologies, Inc.

Integrated DNA Technologies, Inc. (IDT), a Danaher company, is a global leader in custom oligonucleotide synthesis whose contributions to epigenetics research span custom RNA guide sequences for CRISPR-based epigenome editing, xGen target capture probes for methylome sequencing enrichment, synthetic methylated DNA standards and spike-in controls for bisulfite sequencing quality control, and antisense oligonucleotides for epigenetic regulatory element functional studies. Their Alt-R CRISPR-Cas9 system, combined with dCas9-based epigenome editing tools, enables researchers to precisely modulate DNA methylation and histone modifications at specific genomic loci, providing powerful experimental tools for establishing causal epigenetic mechanisms in disease models. IDT's precision oligonucleotide chemistry, stringent quality control, and broad epigenetics-relevant product portfolio make them an indispensable reagent and tools partner for the global epigenetics research and drug discovery community.

25. Novogene Co., Ltd.

Novogene Co., Ltd. is one of the world's largest genomics services companies whose epigenomics service portfolio—spanning whole genome bisulfite sequencing, RRBS, EPIC methylation arrays, ChIP-seq, ATAC-seq, m6A RNA methylation sequencing, and single-cell epigenomics—serves research customers across more than 60 countries with large-scale, high-quality epigenome profiling at competitive pricing enabled by their ultra-high-throughput sequencing infrastructure. Their global sequencing centers in China, the UK, the US, and Singapore operate at a scale that enables population-scale methylome studies and large pharmaceutical epigenomics programs requiring analysis of hundreds to thousands of samples with consistent quality and turnaround. Novogene's combination of sequencing scale, epigenomics service breadth, competitive pricing, and growing bioinformatics capabilities makes them one of the most accessible and practically significant epigenomics services providers for the global research community.