ACL Graft Market by Type of ACL Surgery (Reconstruction, Revision), Age (Above & Below 19 years), Gender (Male, Female), Injury (Sports Injuries (Basketball, Football), Non-sports Injuries (Road Accidents, Falls)), End User - Global Forecast to 2029
Market Growth Outlook Summary
The global ACL graft market growth forecasted to transform from $0.12 billion in 2024 to $0.18 billion by 2029, driven by a CAGR of 7.2%. The market growth is primarily driven by the increasing age-related orthopedic complications, including ACL injuries, along with the growing geriatric population. Increased healthcare expenditure and the expansion of healthcare facilities globally are significant opportunities for market players. In addition, government policies that support healthcare funding and prioritize orthopedic treatments are facilitating access to ACL surgeries, which is driving demand for ACL grafts.
Attractive Opportunities in ACL Graft Market
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ACL Graft Market Dynamics
DRIVER: GROWING AGING POPULATION THAT IS MORE SUSCEPTIBLE TO ORTHOPEDIC COMPLICATIONS
The increasing incidences of knee injuries, including ACL injuries among the growing geriatric population, are one of the major driving factors of the ACL graft market. The rising number of physically active individuals aged 50 and above globally has resulted in an increased incidence of ACL tears within this demographic. The Centers for Disease Control and Prevention (CDC) has estimated that over 14 million older individuals in the US are at risk of sustaining these injuries annually. Falls are the primary cause of injuries and deaths among the elderly population, posing a significant public health concern as the second leading cause of fatal injuries globally. In 2022, adults aged 65 and above experienced over 3,000 fatal falls each month, resulting in 40,923 fatal fall injuries.
The increasing demand for ACL reconstruction procedures among the geriatric population highlights the crucial need for ACL grafts in this demographic segment. According to WHO, the number of people aged 60 and above is projected to double, reaching 2.1 billion by 2050. Therefore, the need for ACL reconstruction surgeries is expected to rise due to a projected rise in orthopedic injuries associated with sports among adults 65 years of age and above.
RESTRAINT: RISKS ASSOCIATED WITH ACL GRAFT SURGERY
Infection, graft failure, persistent pain, and knee stiffness are some of the potential risks associated with ACL graft surgery. Numbness is a common side effect that might happen in the leg, foot, or outside upper leg close to the surgery site. Instability is another risk, affecting 5% to 10% of patients due to stretching the reconstructed tendon. Some individuals experience knee stiffness or loss of mobility caused by excess scar tissue, potentially requiring further surgical intervention or manipulation under anesthesia. Postoperative knee pain, including discomfort at the front of the knee, behind the kneecap, or while kneeling, is also frequently reported.
Allografts may present unique risks for younger people, particularly those under the age of 30. They have been frequently associated with an increased risk of early graft failure in this age range as a result of the recipient's immune system rejecting the cadaveric tissue. An inflammatory response and eventual graft failure may result from the body's immune system targeting and rejecting the graft. The risk factors related to ACL graft procedures are impeding the expansion of the market.
OPPORTUNITY: EXPANSION OF HEALTHCARE FACILITIES AND INCREASED HEALTHCARE EXPENDITURE
The need for ACL grafts is expected to rise significantly due to the expansion of healthcare facilities and rising healthcare expenditure. The need for essential surgical supplies, including ACL grafts, is growing in tandem with the establishment of new hospitals, ambulatory surgery centers, and emergency care facilities. There is an increasing demand for high-quality ACL grafts driven by the adoption of advanced technologies in healthcare infrastructure and enhanced surgical capabilities.
The number of hospitals and surgical centers is increasing in developed as well as emerging economies. The demand for ACL grafts is high in newly established surgical centers and hospitals due to the growing patient population base and the rising number of surgical procedures such as knee replacements.
The American Hospital Association (AHA) 2024 reports that there are 6,120 hospitals in the US. Also, according to the Office for National Statistics, in 2022, the net capital expenditure of the UK on healthcare was USD 12.26 billion, reaching its highest level since 2009. Therefore, the rising number of healthcare facilities, including hospitals, along with increased investments in healthcare systems and the growing demand for surgeries and medical interventions, are creating opportunities for the growth of the ACL graft market.
CHALLENGE: DISCREPANCIES IN AVAILABILITY OF INSURANCE FOR ACL SURGERY
The inconsistency in insurance coverage for ACL surgeries presents a substantial challenge for the ACL graft market. Variations in insurance policies can result in uneven access to essential surgical interventions, impacting patient results and affecting the demand for ACL grafts. Areas or individuals with restricted insurance coverage may encounter financial obstacles, potentially resulting in postponed or avoided surgeries. This can affect market expansion and give rise to inequalities in the adoption of ACL grafts among diverse demographics and geographic areas.
According to an article (Out-of-pocket expenses for ACL reconstruction increased despite a decrease in reimbursement), ACL reconstruction surgery is among the highest-volume orthopedic procedures in the US, and it is witnessing high out-of-pocket expenses for patients as they are responsible for a larger share of their healthcare costs. Health insurance companies are cutting reimbursements and steering procedures towards more cost-effective facilities like ambulatory surgery centers. This change boosts insurers' profits but does not translate into cost savings for patients or healthcare providers. This pattern is adding to the growing financial strain on patients who require ACL reconstruction.
ACL Graft Market Ecosystem
The ACL graft market ecosystem includes manufacturers, distributors, and end users of ACL grafts. The key manufacturers of ACL grafts are LifeNet Health (US), MTF Biologics (US), RTI Surgical (US), Arthrex Inc. (US), and Parametrics Medical (US). Redline Surgical (US) and Biovault Technical (UK) are among the few distributors in the ACL graft market. Cleveland Clinic (US), Mount Sinai (US), Heidelberg University Hospital (Germany), and Mayo Clinic (US) are the end users in the market.
ABOVE 19 YEARS SEGMENT CAPTURED LARGEST MARKET SHARE IN 2023 AND IS PROJECTED TO REGISTER HIGHEST CAGR DURING FORECAST PERIOD, BY AGE GROUP
Based on age group, the ACL graft market is segmented into 19 years and below and above 19 years. The above 19 years segment accounted for the largest share of the ACL graft market in 2023 and is projected to register the highest CAGR during the forecast period. This growth can be attributed to the increasing participation of older adults in sports and athletic activities. More individuals in this age group are engaging in physical activities that predispose them to ACL injuries. Furthermore, according to a BMC research article, sports are the most common cause of ACL injuries in patients under 30 years of age. Conversely, in individuals over 30 years of age, road traffic accidents (RTA) are a more frequent cause of ACL injuries.
Knee injuries often impose significant physical limitations on individuals over 40. As a result, ACLR surgery is becoming more common among middle-aged and older patients, reflecting the growing demand for ACL grafts in this demographic.
SPORTS INJURIES SEGMENT HELD LARGEST MARKET SHARE IN 2023 AND IS PROJECTED TO RECORD HIGHEST CAGR DURING FORECAST PERIOD, BY INJURY TYPE
Based on injury type, the ACL graft market is segmented into sports injury and non-sports injury. The sports injuries segment had the largest share of the ACL graft market in 2023 and is projected to register the highest CAGR during the forecast period. ACL injuries are prevalent in sports that require abrupt stops, sharp changes in direction, or dynamic movements like jumping and landing, such as soccer, basketball, football, and downhill skiing. As participation in such sports has increased, ACL injuries are growing, which, in turn, influences the demand for ACL grafts positively.
In the sports injuries segment, football accounted for the largest share of the ACL transplant market in 2023. A wider public has been exposed to football due to the growth of youth and amateur competitions. Football players of all ages frequently sustain knee injuries, with ACL injuries being the most common. Players typically need ACL restoration due to the high incidence of ACL injuries; the most common method is a bone-patellar tendon-bone autograft.
IN 2023, NORTH AMERICA ACCOUNTED FOR LARGEST SHARE OF ACL GRAFT MARKET, FOLLOWED BY EUROPE
The six primary regions comprising the global ACL graft market are Latin America, the Middle East & Africa, Asia Pacific, Europe, North America, and the GCC countries. North America accounted for the largest share of the ACL graft market in 2023. The growth of the market in this region is due to the increase in sports-related injuries, rising awareness of advanced surgical techniques, the presence of key market players, and growing healthcare expenditures. North America had a population of 375.07 million in 2023, of which 66.75 million, or 18%, were 65 years of age or older. ACL injuries are among the disorders that are caused by this aging population's increased propensity for musculoskeletal problems and frequent falling or slipping, which is why the need for ACL grafts in reconstructive surgery is on the rise.
The primary drivers of the ACL graft market in the US are the aging population, which is more prone to orthopedic issues, the rising demand for ACL procedures, and the well-established healthcare system. Contact sports such as basketball, football, and soccer are popular in the US. Active participation in these sports activities increases the chance and severity of injuries, leading to a higher demand for ACL grafts in this country.
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Key Market Players
- RTI Surgical (US)
- AlloSource (US)
- MTF Biologics (US)
- LifeNet Health (US)
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Report Metric |
Details |
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Market size available for years |
2022–2029 |
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Base year considered |
2023 |
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Forecast period |
2024–2029 |
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Forecast units |
Value (USD Billion) |
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Segments Covered |
Type of ACL Surgery, Age Group, Gender, Injury Type, End User, and Region |
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Geographies covered |
North America, Europe, Asia Pacific, Middle East & Africa, Latin America, and the GCC Countries |
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Companies covered |
RTI Surgical (US), AlloSource (US), Arthrex, Inc. (US), LifeNet Health (US), Bone Bank Allografts (US), MTF Biologics (US), Parametrics Medical (US), and JRF Ortho (US) |
This research report categorizes the ACL graft market into the following segments and subsegments:
Regional Split
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
- GCC Countries
ACL graft market, by type of ACL surgery
- Primary ACL Reconstruction
- ACL Revision
ACL graft market, by age group
- 19 years and below
- Above 19 years
ACL graft market, by gender
- Male
- Female
ACL graft market, by injury type
- Sports Injuries
- Non-sports Injuries
ACL graft market, by end user
- Hospitals & Ambulatory Surgery Centers
- Specialty Clinics
RECENT DEVELOPMENTS
- In July 2022, AlloSource (US) added quadricep tendons to its AlloConnex line of tendons, ligaments, and fascia. AlloSource's AlloConnex quadricep tendon is a preferred option for cruciate ligament procedures.
Frequently Asked Questions (FAQ):
What are the drivers of the ACL graft market?
The drivers of the ACL graft market include a rise in the aging population that is more susceptible to orthopedic complications, an increase in sports and accident-related injuries, and rising awareness about ACL injuries, along with advancements in surgical techniques and improved graft materials.
Which injury type dominates the ACL graft market?
The sports injuries segment is dominating the ACL graft market. The dominant market share is attributed to the increased participation in sports such as basketball, football, and downhill skiing, which leads to ACL injuries. .
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To determine the current size of the ACL graft market, this study engaged in four main activities. A comprehensive study was conducted using secondary research methods to gather data about the market, its parent market, and its peer markets. The next stage involved conducting primary research to confirm these conclusions, assumptions, and sizing with industry experts throughout the value chain. A combination of top-down and bottom-up methods was used to assess the overall market size. The market sizes of segments and subsegments were then estimated using data triangulation techniques and market breakdown.
The four steps involved in estimating the market size are
Collecting Secondary Data
Within the secondary data collection process, a range of secondary sources were reviewed so as to identify and gather data for this study, including regulatory bodies, databases (like D&B Hoovers, Bloomberg Business, and Factiva), white papers, certified publications, articles by well-known authors, annual reports, press releases, and investor presentations of companies.
Collecting Primary Data
A thorough method was used in the primary research phase, which involved interviewing a wide range of sources from the supply and demand sides. The purpose of these interviews was to obtain the quantitative and qualitative information needed to put up this report. The main sources of information were industry experts from both core and related sectors, as well as preferred manufacturers, distributors, suppliers, pioneers in technology, and organizations involved in every aspect of this industry's value chain. A variety of primary respondents, including important industry stakeholders, subject-matter experts, C-level executives from crucial market companies, and industry advisers, were carefully questioned in-depth. The goal was to gather and validate important qualitative and quantitative insights and to conduct a thorough assessment of future possibilities.
A breakdown of the primary respondents is provided below:
Note 1: Others include sales, marketing, and product managers.
Note 2: Tiers of companies are defined based on their total revenue. As of 2023, Tier 1 = >USD 5 billion, Tier 2 = USD 500 million to USD 5 billion, and Tier 3 = < USD 500 million.
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COMPANY NAME |
DESIGNATION |
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MTF Biologics (US) |
Area Sales Manager |
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AlloSource (US) |
Area Account Manager |
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RTI Surgical (US) |
Consultant |
Market Size Estimation
Both top-down and bottom-up approaches were used to estimate and validate the total size of the ACL graft market. These methods were also used extensively to estimate the size of various subsegments in the market. The research methodology used to estimate the market size includes the following:
Data Triangulation
After arriving at the overall market size applying the process mentioned above, the total market was split into several segments and subsegments. To complete the overall market engineering process and arrive at the exact statistics for all segments and subsegments, data triangulation and market breakdown procedures were employed, wherever applicable. The data was triangulated by studying various factors and trends from both the demand and supply sides.
Market Definition
Allograft anterior cruciate ligament reconstruction is a surgical intervention designed to repair a tear in the anterior cruciate ligament (ACL) of the knee, utilizing donor tissue for grafting.
A strip of donated tendon is used during allograft anterior cruciate ligament reconstruction surgery to strengthen the injured ACL. Donated tendons are obtained from deceased individuals who gave their permission for their tendons to be used in a way that benefits others.
Key Stakeholders
- Manufacturers and Distributors of ACL graft
- Hospitals
- Ambulatory Surgery Centers
- Specialty Clinics
- Tissue Banks
- Orthopedic Surgeons and Medical Staff
- Healthcare Providers
- Market Research and Consulting Firms
- Government Associations
- Venture Capitalists and Investors
Report Objectives
- To define, describe, segment, and forecast the ACL graft market by type of ACL surgery, age group, gender, injury type, end user, and region
- To provide detailed information regarding the major factors influencing the market growth (such as drivers, restraints, opportunities, and challenges)
- To assess the ACL graft market with respect to Porter’s five forces, regulatory landscape, the value chain, the supply chain, ecosystem analysis, patent protection, pricing assessment, key stakeholders, and buying criteria
- To analyze the micromarkets1 with respect to individual growth trends, prospects, and contributions to the overall ACL graft market
- To analyze market opportunities for stakeholders and provide details of the competitive landscape for key players
- To forecast the size of the market segments with respect to six regions, namely, North America, Europe, Asia Pacific, Latin America, the Middle East & Africa, and GCC Countries
- To profile the key players and comprehensively analyze their product portfolios, market positions, and core competencies
- To track and analyze company developments such as product launches, product approvals, and other developments
- To benchmark players within the market using the proprietary Company Evaluation Matrix framework, which analyzes market players on various parameters within the broad categories of business and product excellence
Available Customizations
With the given market data, MarketsandMarkets offers customizations to meet the company’s needs. The following customization options are available for the report:
Geographic Analysis:
Further breakdown of the ACL graft market into specific countries/regions in Europe, Asia Pacific, Latin America, Middle East & Africa, and GCC Countries.
Company Information:
Detailed analysis and profiling of additional market players (up to Five), inclusive of:
- Business Overview
- Financial Information
- Product Portfolio
- Developments (last three years)
Note: Some companies are privately owned, and their revenues are unavailable in the public domain. Hence, revenues for privately owned companies will not be included in their profile. In addition, company developments that are not reported in the public domain will not be included.
Growth opportunities and latent adjacency in ACL Graft Market