Base Editing Market by Product (Platform, Reagents & Kits, Plasmids), Service (gRNA Design, Cell Line Engineering), Type, Targeted base (Cytosine, Adenine), Application (Drug Discovery, Agriculture, Veterinary), and Region - Global Forecast to 2028
Updated on : September 24, 2024
Overview of the Base Editing Market
Base editing market forecasted to transform from $270 million in 2023 to USD $549 million by 2028, driven by a CAGR of 15.2%. The new research study consists of an industry trend analysis of the market. The new research study consists of industry trends, pricing analysis, patent analysis, conference and webinar materials, key stakeholders, and buying behaviour in the market. The growth of the base editing market is largely driven by the rising prevalence of genetic diseases, and the increasing recognition of the role of genetic mutations in various diseases has fueled the demand for precise gene editing technologies.
Base Editing Market - Global Forecast to 2028
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Attractive Opportunities in the Base Editing Market
Global Base Editing Market Dynamics
Driver: Rising prevalence of rare diseases
As the prevalence of rare and orphan diseases continues to rise, there is a growing demand for innovative therapies to address them. This surge in demand has put gene editing technologies at the forefront of rare disease research and treatment. Since rare diseases often stem from genetic mutations, approaches like base editing are now playing a pivotal role in the quest for effective treatments. This increase in the prevalence of rare diseases is expected to drive substantial growth in the base editing market in the coming years, as researchers and medical professionals work to develop novel therapies for these challenging conditions.
Restraint: Ethical & safety concerns
The application of gene editing, even when carried out with noble intentions, carries inherent risks of unforeseen consequences. Alterations made to a single gene can inadvertently influence the regulation of other genes, potentially resulting in unanticipated and long-term effects. The introduction of base editing technology has given rise to legitimate ethical and safety concerns, which serve as significant barriers to its widespread adoption in the market. While base editing is generally recognized for its increased precision compared to traditional CRISPR-Cas9 methods, it is not entirely immune to the possibility of off-target effects. The inadvertent modifications to DNA can give rise to detrimental outcomes, necessitating a vigilant focus on enhancing the safety and specificity of base editing techniques to minimize these risks. As technology continues to advance, it is imperative to engage in transparent and inclusive dialogues aimed at addressing these concerns. This entails weighing the potential benefits against the associated risks and steadfastly upholding ethical and safety principles to navigate the complex landscape of gene editing.
Opportunity: Increasing pipeline of gene therapy & regulatory approvals
The expanding pipeline for gene therapy in the base editing market presents significant opportunities for advancements in the treatment of genetic disorders and other diseases. Gene therapy involves the delivery of therapeutic genes or gene editing tools into the patient's cells to correct genetic mutations, restore normal gene function, or introduce therapeutic genes for targeted treatment. The growing number of gene therapy candidates in the development pipeline highlights the potential for transformative breakthroughs in personalized medicine and the treatment of previously incurable diseases. The base editing market is expected to benefit from the growing number of gene therapy products in the pipeline. There are over 1,000 gene therapy products in development, with over 200 of these products in clinical trials. Most of these products are targeting cancer, but there are also several products targeting genetic disorders, such as haemophilia and cystic fibrosis. For instance, in 2022, the FDA approved the first gene therapy product for the treatment of cancer.
Challenge: Challenges associated with off-target effects
The primary concern with off-target effects is the unintentional modification of DNA sequences at locations other than the intended target. Even minimal off-target changes can lead to undesirable and potentially harmful consequences, such as introducing new mutations or disrupting the function of other genes. While base editors are designed to recognize a specific DNA sequence, they may still bind to similar sequences in the genome, resulting in off-target effects. Developing base editors with enhanced specificity is an ongoing challenge. Researchers are continually working to improve the design and engineering of base editors to reduce the risk of off-target effects. This includes refining the binding domains and the catalytic mechanisms to increase precision.
Global Base Editing Market Ecosystem Analysis
The ecosystem of base editing consists of end users from pharmaceutical & biotechnology companies, academic & research institutes, and contract research organizations base editing product and service providers, reagent & kits suppliers, technology providers, data management & analysis providers, regulatory authorities (ensuring compliance and safety), and collaborative networks promoting knowledge sharing and collaboration. These stakeholders interact and collaborate to drive the advancement of base editing products and services, enhance drug discovery processes, and develop new therapeutics.
Platform held a dominant share in the product & service segment in the base editing industry.
By product and service, the base editing market has been further categorized as product and services. Service segment is further categorized as gRNA design, cell line engineering, and other services. The product segment is further categorized as platform, kits & reagents, plasmids, and base editing libraries. In 2022, platform accounted for the largest share of the base editing market. Base editing platforms are integral for therapeutic genome editing applications, where precision and efficiency are critical. Pharmaceutical and biotechnology companies developing gene therapies prefer comprehensive base editing platforms to ensure accurate and reliable results in therapeutic interventions.
The Cytosine base editor segment is expected to register the fastest growth in the base editing industry during the forecast period.
Based on the targeted base the base editing market has been segmented into cytosine base editor and adenine base editor. In 2022, cytosine base editor accounted for the largest share. This can be attributed to the fact that cytosine base editing allows researchers to model disease-causing mutations more easily by introducing specific changes associated with certain genetic disorders. Technological advancements in the field of proteomics and genomics are expected to support the growth of this segment.
North America accounted for the largest share in Base editing industry in 2022.
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Geographically, the Base editing market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. North America held the dominant share followed by Europe. North America has a well-established infrastructure for funding research and development initiatives, providing financial support to companies working on base editing technologies. Moreover, the regulatory environment in North America is often supportive of innovation in the life sciences sector.
Key players in the global Base editing market include Danaher Corporation (US), Merck KGaA (Germany), Revvity (US), Maravai LifeSciences (US), GenScript (China), Beam Therapeutics (US), Intellia Therapeutics, Inc. (US), Cellectis (France), ElevateBio (US), Creative Biogene (US), Bio Palette Co., Ltd (Japan), Addgene (US), Synthego (US), EdiGene, Inc. (China), Shape TX (US), Pairwise (US), ProQR Therapeutics (Netherlands), QI-Biodesignhttps://www.qi-biodesign.com/ (China), KromaTiD, Inc. (US), and GenKOre. (South Korea).
Scope of the Base Editing Industry
Report Metric |
Details |
Market Revenue in 2023 |
$270 million |
Projected Revenue by 2028 |
$549 million |
Revenue Rate |
Poised to Grow at a CAGR of 15.2% |
Market Driver |
Rising prevalence of rare diseases |
Market Opportunity |
Increasing pipeline of gene therapy & regulatory approvals |
This report categorizes the base editing market to forecast revenue and analyze trends in each of the following submarkets:
By Product & Service
-
Product
- Platform
- Kits & Reagents
- Plasmids
- Base Editing Libraries
-
Services
- gRNA Design
- Cell line engineering
- Other Services
By Type
- DNA base editing
- RNA base editing
By Targeted base
- Cytosine base editing
- Adenine base editing
By Application
- Drug Discovery & Development
- Agriculture
- Veterinary
By End User
- Pharmaceutical & Biotechnology Companies
- Academic & Research Institutes
- Contract Research Organizations
By Region
-
North America
- US
- Canada
-
Europe
- Germany
- UK
- France
- Italy
- Spain
- Rest of Europe (RoE)
-
Asia Pacific (APAC)
- Japan
- China
- India
- South Korea
- Rest of Asia Pacific (RoAPAC)
-
Latin America
- Brazil
- Mexico
- RoLATAM
-
Middle East & Africa
- Middle East
- Africa
Recent Developments of Base Editing Industry
- In May 2023, Revvity entered into a license agreement with AstraZeneca for the technology underlying its Pin-point base editing system, a next-generation modular gene editing platform with a strong safety profile to support their creation of cell therapies for the treatment of cancer and immune-mediated diseases.
- In July 2022, Beam Therapeutics entered a collaboration with Verve Therapeutics. Beam Tx granted Verve Tx a license toward an additional liver-mediated cardiovascular disease target.
- In February 2022, Intellia Therapeutics acquired Rewrite Therapeutics; a private biotechnology company focused on advancing novel DNA writing technologies. This acquisition has expanded Intellia’s industry-leading genome editing toolbox by adding a platform that is highly complementary to its existing CRISPR/Cas9 and base editing technologies.
Frequently Asked Questions (FAQ):
What is the projected market revenue value of the global base editing market?
The global base editing market boasts a total revenue value of $549 million by 2028.
What is the estimated growth rate (CAGR) of the global base editing market?
The global base editing market has an estimated compound annual growth rate (CAGR) of 15.2% and a revenue size in the region of $270 million in 2023.
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This research study involved the extensive use of secondary sources, directories, and databases to identify and collect valuable information for the analysis of the global base editing market. In-depth interviews were conducted with various primary respondents, including key industry participants, subject-matter experts (SMEs), C-level executives of key market players, and industry consultants, to obtain and verify critical qualitative and quantitative information and assess the growth prospects of the market. The global market size estimated through secondary research was then triangulated with inputs from primary research to arrive at the final market size.
Secondary Research
Secondary research was used mainly to identify and collect information for the extensive, technical, market-oriented, and commercial study of the Base editing market. The secondary sources used for this study include Genome Canada, National Human Genome Research Institute (NHGRI), Asia Pacific Society of Human Genetics (APSHG), Genetics Society of America (GSA), European Society of Human Genetics (ESHG), Centers for Common Disease Genomics (CCDG), Genomics England, Center for Cellular and Molecular Biology (CCMB, India), Association for Clinical Genomic Science (ACGS), Japan Agency for Medical Research & Development, Department of Biotechnology (India), Center for Alternatives to Animal Testing (CAAT), National Institute of Environmental Health Sciences (NIEHS), United States Environmental Protection Agency (USEPA), US Food and Drug Administration (US FDA), US Census Bureau, Eurostat, Statista, and Factiva. The Scientist Magazine, ScienceDirect, research journals; corporate filings such as annual reports, SEC filings, investor presentations, and financial statements; press releases; trade, business, professional associations and others. These sources were also used to obtain key information about major players, market classification, and segmentation according to industry trends, regional/country-level markets, market developments, and technology perspectives.
Primary Research
Extensive primary research was conducted after acquiring basic knowledge about the global base editing market scenario through secondary research. Several primary interviews were conducted with market experts from the demand side, such as pharmaceutical and biopharmaceutical companies, CROs, and academic & research institutes, and experts from the supply side, such as C-level and D-level executives, product managers, marketing & sales managers of key manufacturers, distributors, and channel partners. These interviews were conducted across five major regions, including the Asia Pacific, North America, Europe, Latin America, and the Middle East & Africa. Approximately 70% and 30% of the primary interviews were conducted with supply-side and demand-side participants, respectively. This primary data was collected through questionnaires, e-mails, online surveys, personal interviews, and telephonic interviews.
The following is a breakdown of the primary respondents:
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Market Size Estimation
Both top-down and bottom-up approaches were used to estimate and validate the total size of the base editing market. These methods were also used extensively to estimate the size of various subsegments in the market. The research methodology used to estimate the market size includes the following:
Bottom-up Approach
- The key players in the industry and market have been identified through extensive secondary research.
- The revenues generated from the base editing business of leading players have been determined through primary and secondary research.
All percentage shares, splits, and breakdowns have been determined using secondary sources and verified through primary sources.
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Top-down Approach
After arriving at the overall market size from the market size estimation process, the total market was split into several segments and subsegments.
Data Triangulation
To complete the overall market engineering process and arrive at the exact statistics for all segments and subsegments, data triangulation and market breakdown procedures were employed, wherever applicable. The data was triangulated by studying various factors and trends from both the demand and supply sides.
In the process of data triangulation, we employed a multifaceted approach, incorporating primary data collection methods, analysis of the MarketsandMarkets (MnM) repository, and a comprehensive examination of company shares. By integrating insights from these diverse sources, we derived a meticulously validated and reliable estimate for the final market size.
Market Definition
Base editing is a precise and targeted genome editing technique that allows for the specific modification of individual nucleotide bases in a DNA molecule without inducing double-strand breaks. This technology offers a highly controlled and minimally disruptive approach to genomic modifications, reducing the risk of off-target effects associated with other genome editing methods.
Stakeholders
- Genome editing/genome engineering product manufacturers
- Suppliers and distributors of genomic instruments/systems and consumables
- Contract manufacturing organizations
- Pharmaceutical and biotechnology companies
- Contract research organizations
- Government associations and research institutes
- Healthcare associations/institutes
- Regulatory authorities
- Business research firms
- Agricultural companies
- Report Objectives
- To define, describe, segment, and forecast the base editing market by product & service, type, application, end-user, and region
- To provide detailed information about the major factors (drivers, restraints, opportunities, and challenges) influencing the market growth
- To analyze micro markets with respect to individual growth trends, prospects, and contributions to the overall base editing market
- To analyze market opportunities for stakeholders and provide details of the competitive landscape for key players
- To forecast the size of the base editing market in five main regions: North America, Europe, Asia Pacific, Latin America, and Middle East & Africa, along with their respective key countries
- To profile the key players in the base editing market and comprehensively analyze their core competencies and market shares
- To track and analyze competitive developments, such as product & service launches, acquisitions, expansions, collaborations, agreements, and partnerships of the leading players in the base editing market
- To benchmark players within the base editing market using the ‘Competitive Leadership Mapping’ framework, which analyzes market players based on various parameters within the broad categories of business and product strategy
Available Customizations
With the given market data, MarketsandMarkets offers customizations as per the company’s specific needs. The following customization options are available for this report:
Portfolio Assessment
- Product Matrix, which gives a detailed comparison of the product portfolios of the top three companies.
Company Information
- Detailed analysis and profiling of additional market players (up to three).
Geographical Analysis
- A further breakdown of the Rest of Asia Pacific base editing market into other Rest of Asian countries
- A further breakdown of the Rest of European base editing market into other Rest of European countries
- A further breakdown of the Rest of Latin American Base editing market into other Rest of Latin American countries
Growth opportunities and latent adjacency in Base Editing Market