Transfection is an enabler technology used for many cell based research activities with applications spanning production of recombinant proteins and recombinant cell lines, gene therapy, delivery of therapeutics and also drug discovery. This research report provides a brief description on transfection technologies, its evolution, comparative analysis, market landscape analysis, competitive scenario and emerging technology and application trends. Global research and development Network, Innovation and Spin offs have been discussed. The report tracks regional adoption and development trends, providing strategic recommendation to stay active and compete in the market space. An impact analysis of major drivers and restraints influencing the growth of the market is mapped for five year period.
Advances in cell research and therapeutic delivery
Cell research is a major driving factor for transfection market, as more than 60% of the users are of academic institutions and researchers. Research in gene transfer is being performed in in vivo conditions for different therapeutic applications; there is a growing demand for new transfection technologies to address unmet needs for therapeutic delivery which is driving the transfection market.
Home brewReagents restricts sale of commercial kits
Home brew reagents are still the preferred choice of reagents for transfection by researchers all over the world. Most of the researchers prepare their own reagents from their laboratory to conduct their research. This is true for most of the reagent based transfection reactions. This allows them to reduce cost involved in purchasing commercial kits.
New disruptive technologies required to address transfection in hard-to-transfect cells
Transfection is an enabler technology which is used in many cell research activities, however only few cell lines are majorly used in these experiments restricting the scope of the study. Transfection in hard to transfect cells is the need of hour and it is a major challenge. There are few upcoming transfection technologies like nucleofection and magnetofection which are an off-shoot of electroporation, which have the potential to address these challenges but are currently cost prohibitive due to which the technologies may have a much slower uptake in the developing world.
The report also discusses new opportunities for investment in the upcoming areas like Gene therapy, Stem cell research and Electro-chemotherapy.
Different transfection technologies are analyzed through a multi-criteria based decision making process which provides competitive benchmarking. Further, the report analyses technology management strategies and technology road mapping for the forecast period. Profiles of over 20 Key companies in the area of Transfection technology sector have been provided. Key players include Life Technologies, Sigma Aldrich, Lonza, Promega, Qiagen, Bio-Rad, Roche, Polyplus Transfection, Mirius Bio, Maxcyte, etc.
Scope of the Report
A comprehensive analysis of the market size and global revenue has been forecasted based on four segmentation: technology, products, applications and by geography.
On the Basis of Applications: Transfection market is segmented into three categories 1. Therapeutic delivery, 2. Bio-Medical research, 3. Protein production. A brief description of the applications and their revenue is discussed in detail in the report.
On the Basis of Product Type: They have been segmented into two types namely, Reagent and Instrument based.
On the Basis of Geography: North America, Europe, Asia-Pacific, and ROW.
On the Basis of Technology: They have been classified into three categories 1. Physical based transfection, 2. Biochemical based Transfection 3. Viral based transfection. Revenue and forecasts for the growth of these technologies has been discussed in detail.
Transfection (the process of deliberately introducing genes into cells) technologies have been used in life science research and has been exploited for therapeutic delivery like for eg, gene therapy and electro-chemotherapy. The major types of Transfection include physical based (such as electroporation, nucleofection, magnetofection and gene gun), biochemical based(lipofection, calcium phosphate and dextran mediated) and viral based(adeno viruses and adeno-associated viruses based) transfection.
Therapeutic delivery especially for gene therapy has received renewed interests among the industry and hence the demand for more scalable viral vectors is expected to increase, considering new markets in China and Europe. Transfection based methods like electroporation have to be exploited for their potential in order to enhance therapies for cancer in the form of electrochemotherapy.
Over the years, viral mediated and chemical mediated transfection techniques have been widely used for applications such as gene therapy and production of recombinant cell lines. However, due to emerging advantages of physical methods such as electroporation, the global transfection market is expected to witness a much higher growth due to the techniques capability to be applied across hard-to-transfect cells which have not been achieved with conventional methods.
The Global Transfection market has been valued at US$ 385 million in 2012 and is expected to reach US$ 601 million by 2017 growing at a CAGR of 9.32%. Physical based transfection like Electroporation, Nucleofection etc. are the fastest growing market at a CAGR of 16.32%.This is attributed to the accelerated research activities in the area of stem cells and other areas pertaining to cellular therapies and funded research being conducted in Electroporation based projects especially in Europe.
Global Transfection Market Revenue, (2012-2017) (in $ Millions)
Source: Markets and Markets Analysis, Expert Interviews
Asia and Asia pacific regions are the fastest growing markets at a CAGR of 11.5% owing to budding biotechnological companies and research institutes. Although transfection markets in these regions are negatively affected owing to a moderate use of home-brew reagents, demand for commercial reagents is expected to increase considering interests in stem cell research and other hard to transfect cell research.
With regards to North America, demands for physical based methods are expected to increase owing to already established research and development trends in cell research. USA in particular is poised for significant growth in this area due to presence of top innovator firms.
Key-players in this market include Life Technologies, Sigma Aldrich, Lonza, Promega, Qiagen, Bio-Rad, Roche, Polyplus Transfection, Mirius Bio, Maxcyte, etc.
Analysis of Transfection technologies presents a holistic perspective of its current and emerging methodologies and markets. Research in life science i.e. research in cell research and cellular therapies in particular, has been fueling the growth of transfection markets for over three decades. Frontier technologies like Nucleofection, Magnetofection and the like is expected to revolutionize transfection in hard-to-transfect cells.
TABLE OF CONTENTS
1.1 KEY TAKE-AWAYS
1.2 REPORT SCOPE
1.3 RESEARCH METHODOLOGY
1.4 KEY DATA POINTS FROM SECONDARY SOURCES
1.5 KEY DATA POINTS FROM PRIMARY SOURCES
2 EXECUTIVE SUMMARY
3 TRANSFECTION TECHNOLOGIES TECHNOLOGY LANDSCAPE ANALYSIS
3.1 TECHNOLOGY OVERVIEW (INTRODUCTION, EVOLUTION AND MARKET SEGMENTATION)
3.2 TECHNOLOGY VALUE CHAIN ANALYSIS
(WITH TECHNOLOGY CAPABILITY/MATURITY LEVELS)
3.3 COMPARATIVE ANALYSIS OF TRANSFECTION METHODS
(PHYSICAL, BIOCHEMICAL AND VIRAL)
3.4.1 THERAPEUTIC DELIVERY
18.104.22.168 BIOTHERPEUTICS (GENE DELIVERY, PROTEIN DELIVERY)
22.214.171.124 ELECTRO-CHEMOTHERAPY AND ELECTRO-IMMUNOTHERAPY
3.4.2 BIO-MEDICAL RESEARCH
126.96.36.199 TRANSGENIC MODELS
188.8.131.52 GENE & PROTEIN EXPRESSION STUDIES
184.108.40.206 CANCER RESEARCH
220.127.116.11 CELL BASED MICROARRAYS FOR DRUG DISCOVERY & DEVELOPMENT
3.4.3 PROTEIN PRODUCTION (RECOMBINANT PROTEIN, VACCINES)
4 TRANSFECTION - MARKET LANDSCAPE ANALYSIS
4.1 GLOBAL MARKET FORECAST
4.1.1 BY GEOGRAPHY
4.1.2 BY PRODUCTS
4.1.3 BY APPLICATION
4.1.4 BY TECHNOLOGY
4.2 MARKET DYNAMICS
4.2.1 DRIVERS (WITH TIMELINE)
4.2.2 RESTRAINTS/CHALLENGES (WITH TIMELINE)
4.2.3 EMERGING TRENDS
5 GLOBAL R&D PORTFOLIO ANALYSIS
5.1 KEY R&D NETWORKS CURRENT & EMERGING THIS SEGMENT WILL INCLUDE UNIVERSITY
INCUBATOR DIVISIONS; COMPANY VC FUNDED CORPORATE INCUBATOR DIVISIONS)
5.2 UNIVERSITIES WITH POTENTIAL TECHNOLOGIES FOR LICENSING/TECH TRANSFER;
FORM SPIN OFFS
6 INVESTMENT/FUNDING ANALYSIS
6.1 INVESTMENT CLIMATE ASSESSMENT
6.2 INVESTMENTS ON TRANSFECTION
7 TRANSFECTION DIFFUSION ANALYSIS
7.1 TECHNOLOGY ADOPTION & DEVELOPMENT - GEOGRAPHICAL ANALYSIS
7.1.2 NORTH AMERICA
18.104.22.168 KEY RESEARCH AREAS BASED ON ELECTROPORATION IN EUROPEAN UNION
22.214.171.124 FUNDING AND DEVELOPMENT ACTIVITIES IN EUROPEAN UNION
8 COMPETITIVE LANDSCAPE
8.1 MERGERS & ACQUISITIONS, 2007 2012
8.2 PARTNERSHIPS & COLLABORATIONS, 2007 2012
8.3 NEW PRODUCT/TECHNOLOGY DEVELOPMENT INITIATIVES
9 OPPORTUNITY EVALUATION AND TECHNOLOGY BENCHMARKING/ROADMAPPING
9.1 SCENARIO MODELLING
9.2 EVALUATION OF EMERGING OPPORTUNITIES
9.3 TECHNOLOGY BENCHMARKING BASED ON MULTI-CRITERIA DECISION MAKING
9.4 TECHNOLOGY ROAD MAPPING
10 PATENT ANALYSIS
11 ANALYST INSIGHTS AND RECOMMENDATIONS
11.2 TECHNOLOGY MANAGEMENT STRATEGIES
12 COMPANY PROFILES
12.1 LIFE TECHNOLOGIES CORPORATION
12.2 LONZA GROUP LTD.
12.3 PROMEGA CORPORATION
12.4 SIGMA ALDRICH CORPORATION
12.5 THERMO FISHER SCIENTIFIC INC.
12.6 BIO-RAD LABORATORIES INC.
12.7 ROCHE APPLIED SCIENCE
12.8 QIAGEN N.V.
12.9 INOVIO PHARMACEUTICALS INC.
12.10 POLYPLUS TRANSFECTION S.A.
12.11 MIRUS BIO LLC.
12.12 CLONETECH LABORATORIES, INC.
12.13 SIGNAGEN LABORATORIES
12.14 MAXCYTE, INC.
12.17 TECHULON INC.
12.18 DELIVERICS LTD.
12.19 OZ BIOSCIENCES
12.20 MOLECULAR TRANSFER INC.,
12.21 ALTOGEN BIOSYSTEMS
12.22 PROMOKINE GMBH
LIST OF TABLES
TABLE 1 MAPPING OF TECHNOLOGY CAPABILITY AND MATURITY
TABLE 2 GLOBAL TRANSFECTION MARKET REVENUE, 2012-2017 ($ MILLION)
TABLE 3 GLOBAL TRANSFECTION MARKET BY GEOGRAPHY, 2012-2017 ($ MILLION)
TABLE 4 GLOBAL TRANSFECTION MARKET REVENUE BY PRODUCTS, 2012-2017 ($ MILLION)
TABLE 5 GLOBAL TRANSFECTION MARKET REVENUE BY APPLICATIONS 2012-2017 ($ MILLION)
TABLE 6 GLOBAL TRANSFECTION MARKET REVENUE BY TECHNOLGY 2012-2017 ($ MILLION)
TABLE 7 MARKET DYNAMICS - DRIVERS IMPACT TIME LINE
TABLE 8 MARKET DYNAMICS - RESTRAINTS IMPACT TIMELINE
TABLE 9 OPPORTUNITY STRATEGIC EVALUATION ANALYSIS
LIST OF FIGURES
FIG 1 RESEARCH METHODOLOGY
FIG 2 GLOBAL TRANSFECTION MARKET REVENUE, 2012-2017 ($ MILLION)
FIG 3 TECHNOLOGY OVERVIEW
FIG 4 TECHNOLOGY VALUE CHAIN ANALYSIS
FIG 5 TECHNOLOGY CAPABILITY AND MATURITY
FIG 6 TECHNOLOGY LIFE CYCLE ANALYSIS
FIG 7 GLOBAL TRANSFECTION MARKET REVENUE, 2012-2017 ($ MILLION)
FIG 8 GLOBAL TRANSFECTION MARKET - GROWTH RATE BY GEOGRAPHY 2012 2017
FIG 9 GLOBAL TRANSFECTION MARKET SHARE BY GEOGRAPHY 2012
FIG 10 GLOBAL TRANSFECTION MARKET REVENUE BY GEOGRAPHY, 2012-2017 ($ MILLION)
FIG 11 GLOBAL TRANSFECTION MARKET - GROWTH RATE BY PRODUCTS 2012 2017
FIG 12 GLOBAL TRANSFECTION MARKET SHARE BY PRODUCTS 2012
FIG 13 GLOBAL TRANSFECTION MARKET REVENUE BY PRODUCTS, 2012-2017 ($ MILLION)
FIG 14 GLOBAL TRANSFECTION MARKET - GROWTH RATE BY APPLICATIONS 2012 2017
FIG 15 GLOBAL TRANSFECTION MARKET SHARE BY APPLICATIONS 2012
FIG 16 GLOBAL TRANSFECTION MARKET REVENUE BY APPLICATIONS, 2012-2017($ MILLION)
FIG 17 GLOBAL TRANSFECTION MARKET - GROWTH RATE BY TECHNOLOGY 2012 2017
FIG 18 GLOBAL TRANSFECTION MARKET SHARE BY TECHNOLOGY 2012
FIG 19 GLOBAL TRANSFECTION MARKET REVENUE BY TECHNOLOGY 2012-2017 ($ MILLION)
FIG 20 GLOBAL RESEARCH PORTFOLIO-RESEARCH AND DEVELOPMENT NETWORK
FIG 21 ATTRACTIVE FORCES FOR INCREASED MARKET VALUE
FIG 22 ADOPTION RATE OF ELECTROCHEMOTHERAPY (2006-2010)
FIG 23 FUNDING LANDSCAPE IN EU
FIG 24 MARKET SHARE ANALYSIS OF KEY PLAYERS 2012
FIG 25 OPPORTUNITY STRATEGIC EVALUATION ANALYSIS
FIG 26 PRIORITIZATION OF TRANSFECTION TECHNOLOGIES FOR FUTURE ADOPTION
FIG 27 PRIORITY VALUES FOR LEVEL 0
FIG 28 COMPARISON OF TECHNOLOGY BASED ON LEVEL 0 CRITERIA
FIG 29 TECHNOLOGY PRIORITIZATION
FIG 30 NO OF PATENTS PUBLISHED BETWEEN THE YEAR 2007-2012
FIG 31 PERCENTAGE DISTRIBUTION: REAGENTS VS PHYSICAL (2007-2012)