Laser Capture Microdissection Market by Product (Instruments, Consumables, Software, Services), System Type (Ultraviolet, Infrared, Immunofluorescence), Application (R&D (Molecular Biology, Cell Biology, Forensics), Diagnostics) & Region - Global Forecast to 2029
The global laser capture microdissection market in terms of revenue was estimated to be worth $184 million in 2024 and is poised to reach $306 million by 2029, growing at a CAGR of 10.6% from 2024 to 2029. The new research study consists of an industry trend analysis of the market. The new research study consists of industry trends, pricing analysis, patent analysis, conference and webinar materials, key stakeholders, and buying behaviour in the market. The growth of this market is majorly driven by the rising pace of R&D and growing expenditure. On the other hand, requirement of high degree of technical expertise is a major factor restraining market growth to a certain extent.
Attractive Opportunities in Laser Capture Microdissection Market
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Global Laser Capture Microdissection Market Dynamics
DRIVER: Increase in R&D funding
Increased R&D funding enables researchers to explore new applications for LCM across different fields. As more funding becomes available for studying complex diseases like cancer, neurodegenerative disorders, and infectious diseases, the demand for precise cell isolation techniques like LCM grows. For example, in cancer research, LCM allows for the isolation of specific tumor cells for genomic, proteomic, and transcriptomic analysis, leading to a better understanding of disease mechanisms and potential therapeutic targets. For instance, according to the Evaluate Pharma report published in August 2022, the pharmaceutical R&D expenditure across the world was estimated at around USD 256 billion in 2024, an increase of 2.6% from 2021 to 2028. The growth in the R&D expenditure by pharmaceutical and biotechnology companies, coupled with the increasing focus on life science projects for the development of new therapeutic and diagnostic products, is expected to aid the growth of the laser capture microdissection market.
RESTRAINT: Requirement of high degree of technical expertise
Technological advancements have resulted in significant improvements in laser capture microdissection. However, experts with good knowledge of laser capture microdissection as well as the skills are required for instrument and software handling. To adopt the newer technologies of this market, pharmaceutical companies and academic labs require researchers who are well versed with new techniques such as expression microdissection technique. Being a relatively new technology, expression microdissection faces a shortage of skilled and knowledgeable professionals. Due to this, companies tend to opt for microscopic techniques. All these factors make laser capture microdissection development a tedious process and thus limit its uptake among researchers. Moreover, the complexity of the instrumentation is also restraining the growth of the market as it restricts only the use by the technical expertise. Dearth of training is therefore a hurdle to the growth of the laser capture microdissection market.
OPPORTUNITY: Integration with omics technologies
LCM can be integrated with various omics technologies, such as genomics, transcriptomics, proteomics, and metabolomics, to obtain comprehensive molecular profiles of isolated cells or tissue regions. This integration enables researchers to gain insights into the molecular mechanisms underlying diseases and biological processes at a high resolution. As omics-based research continues to advance, the demand for LCM technologies that seamlessly integrate with omics workflows is expected to grow, creating opportunities for market expansion. According to the article published in the Journal of Genetics and Genomics in September 2023, conducted a study on Laser capture microdissection for biomedical research: towards high-throughput, multi-omics, and single-cell resolution, stated that LCM is highly compatible with spatially resolved multi-omics analysis, including genomics, epigenomics, transcriptomics, proteomics, and metabolomics, by dissecting samples with less contamination at single-cell resolution.
CHALLENGE: Time-consuming sample preparation process
Molecular profiling (sample preparation) in laser capture microdissection is a major challenge for the laser capture microdissection market as it is very tedious and mainly depends upon the quantity of the sample required for the further downstream processes. LCM enables differentiation between the normal and diseased cells or tissue; hence, an isolation of a particular cell should be performed keenly, which in turn is time-consuming. Sample preparation of laser capture microdissection usually contains visualization of the cells of interest via microscope, dissection of the selected cells by the transfer of a laser energy to a thermolabile polymer with formation of a polymer-cell composite (IR system) or photo volatilization of cells surrounding a selected area (UV system), and then the capture or catapult of the cells of interest from the heterogeneous tissue section. The long and labor-intensive nature of the technique is a major challenge for the market.
Laser Capture Microdissection Industry Ecosystem
The laser capture microdissection market is a complex ecosystem involving various stakeholders, including the supply side, which includes companies providing laser capture microdissection products & services. The demand side includes academic and government research institutes, hospitals, pharmaceutical & biotechnology companies, and contract research organizations.
Several key companies provide laser capture microdissection. For example, Thermo Fisher Scientific, Inc. (US) is the leading market player. The company has maintained its leadership through its strong distribution network across Asia-Pacific, Latin America, Europe, the Middle East and Africa, and North America. It focuses on expanding its presence in the market by strategically investing in R&D to launch innovative and advanced products in the market. Other product providers include Danaher Corporation (US), Carl Zeiss AG (Germany), F. Hoffmann-La Roche AG (Switzerland), and Standard BioTools, Inc. (US), and others.
The reagents & media sub-segment under consumables segment dominated laser capture microdissection industry by product
Laser capture microdissection is an extremely useful tool for researchers in various medical/healthcare fields. It is commonly used in hospitals & academic and government research institutes for a myriad of applications, including research and diagnostics. The use of high-performance media and reagents helps in yielding better results. Reagents are used in laser capture microdissection for tissue staining, DNA/RNA extraction & purification, RNA amplification & extraction, formalin-fixed, paraffin-embedded tissue procedures, and RNA labeling. Other important reagents include buffers, dyes, and stains. Media is often complemented with supplements such as amino acids, inorganic salts, and glucose; it is also complemented with serum for cell proliferation. Growth medium helps maintain pH and osmolality. Media is primarily used to ensure immediate survival of cells, prolonged survival of cells, and indefinite/continuous growth and specialized functions. The addition of media also enhances cell performance. In laser capture microdissection, media is mainly used to study the live cells in the samples.
The molecular biology seb-segment under research and development segment dominated laser capture microdissection industry by application
Laser capture microdissection (LCM) is a powerful technique widely utilized in molecular biology for various applications due to its ability to isolate specific cells or tissue regions from complex samples with high precision. LCM allows researchers to isolate individual cells or small groups of cells from heterogeneous tissue samples. Isolated cells can then be subjected to downstream molecular analyses at the single-cell level, including gene expression profiling, DNA sequencing, epigenetic analysis, and proteomic characterization. This enables the study of cellular heterogeneity, cell-to-cell variability, and rare cell populations within tissues. In 2022, Maastricht University published research study for Laser Capture Microdissection-Based mRNA Expression Microarrays and Single-Cell RNA Sequencing in Atherosclerosis Research.
Asia Pacific is estimated to register the highest CAGR in the laser capture microdissection industry during the forecast period.
Asia Pacific offers lucrative growth potential for the laser capture microdissection market. This can be attributed to the increasing pharmaceutical R&D spending, the growing trend of outsourcing drug discovery services, growing life sciences research, and increasing government initiatives for healthcare research. One significant growth driver for the market in the Asia Pacific region is the increasing investment in healthcare infrastructure and research & development (R&D) activities. Governments and private entities are allocating substantial funds and launching various research programs to enhance healthcare facilities and promote scientific advancements, including laser capture microdissection technologies. These investments are driving the adoption of laser capture microdissection techniques across various applications and research fields
The Asia-Pacific Economic Cooperation (APEC) Life Sciences Innovation Forum (LSIF) and its Regulatory Harmonization Steering Committee (RHSC) adopted a strategic plan (Vision 2020: A Strategic Framework: Regulatory Convergence for Medical Products by 2020). This strategic plan provided the basic proposal and rationale for achieving regional regulatory convergence of medical product approval procedure. The forum’s vision is to accelerate regulatory convergence for medical products in the APEC region as much as possible by 2030 to protect people’s safety, make life-saving products available, save public resources, attract investments, mitigate corruption, and improve global standing in every APEC economy. Thus, favourable regulatory guidelines for product approval are expected to drive the market growth.
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Key players in the laser capture microdissection market include Thermo Fisher Scientific Inc. (US), Danaher Corporation (US), Carl Zeiss AG (Germany), F. Hoffmann-La Roche AG (Switzerland), Standard BioTools (US), JSR Corporation (Japan), Bio-Rad Laboratories, Inc. (US), Agilent Technologies, Inc. (US), Bruker (US), Molecular Machines & Industries GmbH (Germany), Ocimum Biosolutions (US), Theralink Technologies, Inc. (US), 3DHISTECH, Ltd. (Hungary), Creative Biolabs (US), DeNova Sciences (Singapore), Laxco, Inc. (US), CaresBio Laboratory LLC (US), VitroVivo Biotech (US), AnaPath Services GmbH (Switzerland), Gnome Diagnostics & Gnome Sciences (US), Monasterium Laboratory (Germany), Independent Forensics (US), Norgen Biotek Corp. (Canada), Creative Bioarray (US), and Epistem Ltd. (UK).
Scope of the Laser Capture Microdissection Industry
|
Report Metric |
Details |
|
Market Revenue in 2024 |
$184 million |
|
Projected Revenue by 2029 |
$306 million |
|
Revenue Rate |
Poised to Grow at a CAGR of 10.6% |
|
Market Driver |
Increase in R&D funding |
|
Market Opportunity |
Integration with omics technologies |
This report categorizes the Laser Capture Microdissection Market to forecast revenue and analyze trends in each of the following submarkets:
By Product
- Instruments
-
Consumables
- Reagents & Media
- Assay Kits
- Other Consumables
- Software and services
By System Type
- Ultraviolet LCM
- Infrared LCM
- Ultraviolet and Infrared LCM
- Immunofluorescence LCM
By Application
-
Research and Development
- Molecular Biology
- Cell biology
- Forensic Science
- Diagnostics
- Other Applications
By End User
- Academic and government Research Institutes
- Hospitals
- Pharmaceutical & Biotechnology Companies
- Contract Research Organizations
By Region
- North America
- US
- Canada
- Europe
- Asia Pacific (APAC)
- Rest of the World
Recent Developments of Laser Capture Microdissection Industry:
- In August 2023, Danaher Corporation (US) acquired Abcam plc (UK), a leading supplier of protein consumables. Abcam is to operate as a standalone operating company and brand within Danaher's Life Sciences segment, furthering Danaher's strategy to help map complex diseases and accelerate the drug discovery process using Danaher’s technology.
- In March 2023, Crown Bioscience International (US), a JSR Life Sciences Company, acquired a 100.0% stake in Indivumed Services GmbH& Co. KG (Germany) to further accelerate drug discovery and create solutions to meet customer needs by bringing a variety of synergistic service platforms to Crown Bioscience's drug discovery and development services.
Frequently Asked Questions (FAQ):
What is the projected market revenue value of the global laser capture microdissection market?
The global laser capture microdissection market boasts a total revenue value of $306 million by 2029.
What is the estimated growth rate (CAGR) of the global laser capture microdissection market?
The global laser capture microdissection market has an estimated compound annual growth rate (CAGR) of 10.6% and a revenue size in the region of $184 million in 2024. .
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This research study involved the extensive use of Secondary sources, directories, and databases were used extensively to identify and collect helpful information for this technical, market-oriented, and financial study of the global laser capture microdissection market. In-depth interviews were conducted with various primary respondents, including key industry participants, subject-matter experts (SMEs), C-level executives of key market players, and industry consultants, among other experts, to obtain and verify critical qualitative and quantitative information and to assess the market growth prospects. The global size of the laser capture microdissection market (estimated through various secondary research approaches) was then triangulated with inputs from primary research to arrive at the final market size.
Secondary Research
The secondary sources referred to for this research study include directories; databases such as Bloomberg Businessweek, Factiva, and Wall Street Journal; white papers; and clinicaltrial.gov, among others. Secondary sources also include corporate and regulatory filings (such as annual reports, SEC filings, investor presentations, and financial statements); business magazines and research journals; press releases; and trade, business, and professional associations. Secondary data was collected and analyzed to arrive at the overall size of the global laser capture microdissection market, which was validated through primary research. Some of the key secondary sources referred to for this study include, National Center for Biotechnology Information (NCBI), Scientific Journals, World Bank, World Health Organization, Association of Clinical Research Organizations (ACRO), Association of International Contract Research Organizations (AICROS), Clinical and Contract Research Association (CCRA), American Association of Pharmaceutical Scientists (AAPS), Pharmaceutical Research and Manufacturers of America (PhRMA), Safety Pharmacology Society (SPS), Organization for Economic Co-operation and Development (OECD).
Primary Research
Extensive primary research was conducted after acquiring basic knowledge about the global laser capture microdissection market scenario through secondary research. Several primary interviews were conducted with market experts from both the demand-side personnel (such as contract research organizations (specialists), academic medical researchers, scientists, and pharmaceutical and biopharmaceutical company experts) and supply-side (such as CEOs, vice presidents, marketing and sales directors, technology and innovation directors, and related key executives from various companies and organizations operating in the market) across four major regions—North America, Europe, the Asia Pacific, and Rest of the World. Approximately 60% and 40% of primary interviews were conducted with supply-side and demand-side participants respectively. This preliminary data was collected through questionnaires, e-mails, online surveys, personal interviews, and telephonic interviews.
The following is a breakdown of the primary respondents:
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Market Size Estimation
The global size of the market was estimated through multiple approaches. A detailed market estimation approach was followed to estimate and validate the value of the laser capture microdissection market and other dependent submarkets. These methods were also used extensively to estimate the size of various subsegments in the market. The research methodology used to estimate the market size includes the following:
- The key players in the industry and market have been identified through extensive primary and secondary research.
- The revenues generated from the laser capture microdissection business of leading players have been determined through primary and secondary research.
- All percentage shares, splits, and breakdowns have been determined using secondary sources and verified through primary sources.
Global Laser Capture Microdissection Market: Bottom Up Approach
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Global Laser Capture Microdissection Market: Top Down Approach
Data Triangulation
After arriving at the market size from the market size estimation process explained above, the total market was divided into several segments and subsegments. Data triangulation and market breakdown procedures were employed, wherever applicable, to complete the overall market engineering process and arrive at the exact statistics for all segments and subsegments.
Market Definition
Laser capture microdissection (LCM) is a contact- and contamination-free method of isolating specific single cells or entire areas of tissues from a wide variety of samples using a focused laser beam. This technique preserves the original morphology of the dissected tissue sample. Materials obtained by laser capture microdissection can be used for downstream assays like gene microarrays, loss-of-heterozygosity analysis, mass spectrometry proteomics discovery, signal pathway profiling, western blotting, cDNA library generation, and DNA genotype.
Laser capture microdissection technique is majorly used in genetic analysis, molecular analysis, cell isolation, microarrays, and protein analysis.
Key Stakeholders
- Hospitals
- Cancer Research Institutes
- Academic and Government Research Institutes
- Market Research and Consulting Firms
- Laser Capture Microdissection Manufacturers, Vendors, and Distributors
- Pharmaceutical and Biotechnology Companies and Contract Research Organizations (CROs)
- Healthcare Associations/Institutes
- Business Research & Consulting Service Providers
- Venture Capitalists & Investors
Report Objectives
- To define, describe, and forecast the global Laser Capture Microdissection Market based on product, system type, application, end user, and region
- To provide detailed information regarding the major factors influencing the growth of the market (such as drivers, restraints, opportunities, and challenges)
- To strategically analyze micro markets with respect to individual growth trends, prospects, and contributions to the overall market
- To analyze the opportunities in the market for stakeholders and provide details of the competitive landscape for market leaders
- To forecast the size of the market segments with respect to four main regions, namely, North America, Europe, the Asia Pacific, and the Rest of the World
- To profile the key players and comprehensively analyze their product portfolios, market positions, and core competencies
- To track and analyze competitive developments such as acquisitions, product launches, expansions, agreements, partnerships, and collaborations in the market
Available Customizations
With the given market data, MarketsandMarkets offers customizations as per the company’s specific needs. The following customization options are available for this report:
Geographical Analysis
- Further breakdown of the Europe Laser Capture Microdissection Market, by country
- Further breakdown of the Asia Pacific Laser Capture Microdissection Market, by country
- Further breakdown of the Rest of the World, by region
Company Information
- Detailed analysis and profiling of additional market players (up to five)
Segment Analysis
- Further breakdown of the product segment as per the product portfolio of prominent players operating in the market.
Generating Response ...
Growth opportunities and latent adjacency in Laser Capture Microdissection Market