US Liquid Biopsy Market (2025-2030)
The US Liquid Biopsy Market was valued at $947.7 Million in 2025 and projected to reach to $1660.1 Million by 2030, representing a compound annual growth rate of 11.9%. The US liquid biopsy market is positioned for sustained expansion through 2030, driven by technological advancements, regulatory approvals, and increasing clinical validation of liquid biopsy applications.
US Liquid Biopsy Market Trends and Insights
- The US market is driven by increasing adoption of non-invasive diagnostic technologies, rising cancer incidence rates, and growing investment in precision medicine infrastructure.
- In the US, liquid biopsy platforms are gaining traction across oncology, cardiology, and prenatal screening applications, supported by favorable reimbursement policies and strong healthcare spending. The US liquid biopsy sector benefits from a mature healthcare ecosystem with advanced laboratory capabilities and high patient awareness.
- By 2030, the US market is expected to capture significant share through expanded clinical validation, integration into standard-of-care protocols, and commercialization of next-generation sequencing-based assays.
- The US regulatory environment, led by FDA oversight, continues to accelerate approval pathways for innovative liquid biopsy tests, positioning the country as a global leader in market adoption and innovation..
Key Market Statistics
- CAGR (2025-2030) 11.9% CAGR
- Market Size, 2025 ~USD 947.7 Million
- Forecast, 2030 ~USD 1660.1 Million
- Country US
US Liquid Biopsy Market Overview
Market Valuation Growth :
The US liquid biopsy market is valued at $947.7 million in 2025 and is projected to reach $1,660.1 million by 2030, representing a robust 11.9% CAGR over the forecast period.
Non-Invasive Diagnostic Adoption :
US healthcare providers are increasingly adopting liquid biopsy technologies as preferred alternatives to traditional tissue biopsies, driven by patient preference for minimally invasive procedures and faster turnaround times.
Cancer Incidence & Precision Medicine :
Rising cancer incidence rates across the US population combined with substantial investment in precision medicine infrastructure are accelerating the integration of liquid biopsy platforms into oncology treatment protocols.
Oncology Platform Expansion :
Liquid biopsy platforms are gaining significant traction across US oncology departments, with expanding applications in early detection, treatment monitoring, and minimal residual disease assessment.
US Liquid Biopsy Market Dynamics
- Healthcare systems across the country are investing in these platforms to enhance cancer detection capabilities and improve patient outcomes through earlier intervention.
- The convergence of rising cancer prevalence, growing reimbursement coverage, and strong R&D investment from both established diagnostics companies and innovative startups will continue to propel market growth.
- Additionally, integration of liquid biopsy into standard oncology workflows and expansion into non-oncology applications will create new revenue streams and market opportunities throughout the forecast period..
Related Ecosystem
Advanced Genetic Sequencing
- Polymerase Chain Reaction (PCR)
- Reagents
- Assay Kits
- Bioinformatics
- Flow Cytometry
- Thermo Fisher Scientific Inc.
- Illumina, Inc.
- Qiagen N.V.
- Agilent Technologies, Inc.
- Danaher Corporation
In Vitro Diagnostics
- Polymerase Chain Reaction (PCR)
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Dna Microarrays
- Assay Kits
- Microarrays
- ROCHE HOLDINGS AG
- Thermo Fisher Scientific Inc.
- Danaher Corporation
- Abbott Laboratories
- Biomerieux s.a.
Medical Devices
- Polymerase Chain Reaction (PCR)
- Magnetic Resonance Imaging (MRI)
- Disposable Autoinjectors
- Pulse Oximeters
- Blood Pressure Monitors
- Medtronic plc
- Abbott Laboratories
- Stryker Corporation
- Becton, Dickinson and Company
- JOHNSON & JOHNSON
Key Takeaways
- The US liquid biopsy market is valued at $947.7 million in 2025 and will reach $1,660.1 million by 2030, representing a 11.9% CAGR.
- The US market is driven by non-invasive diagnostic demand, rising cancer prevalence, and precision medicine investments across healthcare systems.
- In the US, favorable FDA approval pathways and reimbursement coverage are accelerating clinical adoption and market penetration.
- The US liquid biopsy sector is expanding beyond oncology into cardiology and prenatal screening, broadening addressable market opportunities.
Liquid Biopsy Market Report Scope
| Report Metric | Details |
|---|---|
| Base Year | 2025 |
| Fastest Growing Segment | CIRCULATING TUMOR DNA (Circulating Biomarker Type) |
| Forecast Period | 2025–2030 |
| Growth Rate | CAGR of 11.8% from 2025 to 2030 |
| Largest Segment | BLOOD (Sample Type) |
| Market Size Base Year (Billions) | ~USD 4.04 (2025) |
| Revenue Forecast (Billions) | ~USD 7.05 (2030) |
| Segments Covered | Product & Service, Circulating Biomarker Type, Technology, Application, Type, Clinical Application, Sample Type, End User |
US Liquid Biopsy Market Report Segmentation
8 segment dimensions are covered across the global market.
By Product & Service
- Assay Kits
- Instruments
- Services
By Circulating Biomarker Type
- Cell-Free Dna
- Circulating Tumor Cells
- Circulating Tumor Dna
- Extracellular Vesicles
- Other Circulating Biomarkers
By Technology
- Multi-Gene Parallel Analysis Using Ngs
- Single-Gene Analysis Using Pcr Microarrays
By Application
- Cancer Applications
- Non-Cancer Applications
By Type
- Breast Cancer
- Colorectal Cancer
- Infectious Disease Testing
- Lung Cancer
- Melanoma
- Non-Invasive Prenatal Testing
- Organ Transplantation
- Other Cancers
- Prostate Cancer
By Clinical Application
- Early Cancer Screening
- Recurrence Monitoring
- Therapy Selection
- Treatment Monitoring
By Sample Type
- Blood
- Other Sample Types
By End User
- Academic & Research Centers
- Hospitals & Physician Laboratories
- Hospitals & Physicians Laboratories
- Other End Users
- Reference Laboratories
Target Audience
- Diagnostic Companies & IVD Manufacturers : Need comprehensive US market data to guide product development, commercialization strategies, and competitive positioning in the rapidly expanding American liquid biopsy sector.
- Healthcare Providers & Hospital Systems : Require market insights to evaluate liquid biopsy technology adoption, assess vendor options, and understand reimbursement landscapes for integrating these platforms into US oncology departments.
- Investment & Private Equity Firms : Seek detailed US market forecasts and growth drivers to identify investment opportunities, assess portfolio company potential, and evaluate acquisition targets in the liquid biopsy space.
- Pharmaceutical & Biotech Companies : Need US-specific market data to understand companion diagnostic opportunities, develop precision medicine strategies, and identify partnerships with liquid biopsy technology providers.
- Healthcare Consultants & Analysts : Require granular US market intelligence to support client advisory work, competitive benchmarking, and strategic planning across oncology diagnostics and precision medicine initiatives.
Key Companies in the US Liquid Biopsy Market
| Company | HQ | Ownership | Strongest segments |
|---|---|---|---|
| SANOFI | France | Public Company | Vaccines (pediatric, hexavalent, travel and epidemic),Immunology & Inflammation,Rare Diseases & Neurology, |
| CONMED CORPORATION | United States | Public Company | Orthopedic sports medicine and power tools (BioBrace, Y-Knot, Hall, related disposables),General surgery and minimally invasive platforms (AirSeal, Buffalo Filter, endomechanical, electrosurgery),Endoscopic technologies and patient monitoring (GI therapeutics, ECG/EEG, defibrillation pads), |
| HOLOGIC, INC. | United States | Private Company | Diagnostics (Aptima, Panther, ThinPrep, viral load, SARS-CoV-2),Breast Health (3D mammography, biopsy, markers, localization, treatment),GYN Surgical (MyoSure, NovaSure, Fluent, Acessa ProVu, CoolSeal), |
| UNITED IMAGING HEALTHCARE CO., LTD. | China | Public Company | Magnetic Resonance Imaging,Computed Tomography,Molecular Imaging (PET/CT, SPECT), |
| NATERA, INC. | United States | Public Company | Oncology MRD and CGP (Signatera, Latitude, Altera, Empower oncology use),Women’s health (Panorama, Horizon, Fetal Focus, Vistara, Anora),Transplant and nephrology (Prospera, Renasight), |
| GUARDANT HEALTH | United States | Public Company | Guardant360 liquid portfolio (CDx and Guardant360 Liquid),Guardant Reveal and minimal residual disease testing,Guardant360 Tissue and tissue-based profiling, |
| MYRIAD GENETICS, INC. | United States | Public Company | Hereditary and Companion Diagnostics (MyRisk, BRACAnalysis CDx, MyChoice CDx),Oncology Prognostics and Tumor Profiling (Prolaris, EndoPredict, Precise Tumor),Women’s Health and Prenatal (Prequel, Foresight, SneakPeek, FirstGene), |
| ILLUMINA, INC. | United States | Public Company | Sequencing instruments,Sequencing consumables (reagents, flow cells, library prep, WGS and targeted kits),Arrays and genotyping products, |
| QIAGEN N.V. | Netherlands | Public Company | Sample technology consumables and instruments,Immune response and infectious disease diagnostics,Oncology and sexual and reproductive health assays, |
| EXACT SCIENCES CORPORATION | United States | Private Company | Cologuard and Cologuard Plus,Oncotype DX breast and colon tests,Hereditary and risk assessment tests (Riskguard, Cancerguard, Genetic Testing), |
| THERMO FISHER SCIENTIFIC INC. | United States | Public Company | Life Sciences Solutions,Analytical Instruments,Specialty Diagnostics, |
| GRAIL, INC. | United States | Public Company | Galleri multi-cancer early detection screening,Diagnostic aid for suspected cancer,Precision oncology and MRD/monitoring (RUO methylation platform), |
| BIO-RAD LABORATORIES, INC. | United States | Public Company | Life Science segment,Clinical Diagnostics segment, |
| SYSMEX CORPORATION | Japan | Public Company | Hematology analyzers and reagents (XN-Series, XN-V, ProCyte Dx),Coagulation analyzers and reagents,Urinalysis, blood gas/electrolyte, and related analyzers, |
| MDXHEALTH | Belgium | Public Company | Confirm mdx (prostate cancer tissue test),ExoD (non-invasive urine prostate cancer test),Genomic Prostate Score collaboration, |
| PERSONALIS, INC. | United States | Public Company | Pharma and biopharma research services (ImmunoID NeXT, exome/transcriptome projects),MRD and clinical liquid biopsy (NeXT Personal, NeXT Personal Dx),Comprehensive tumor profiling and Dx (NeXT Dx and related tests), |
SANOFI
Sanofi is a French multinational pharmaceutical company founded in 1994 with 74,846 employees, operating as a public company in the healthcare and drug development sector.
CONMED CORPORATION
CONMED Corporation is a U.S.-based public company founded in 1970 with 3,900 employees that manufactures and distributes medical devices and equipment.
HOLOGIC, INC.
Hologic, Inc. is a private U.S. company founded in 1985 with 7,070 employees focused on diagnostic and surgical medical devices.
UNITED IMAGING HEALTHCARE CO., LTD.
United Imaging Healthcare Co., Ltd. is a Chinese public company founded in 2011 with 8,703 employees specializing in medical imaging equipment and solutions.
NATERA, INC.
Natera, Inc. is a U.S. public company founded in 2003 with 6,138 employees providing genetic testing and cell-free DNA analysis services.
GUARDANT HEALTH
Guardant Health is a U.S. public company founded in 2011 with 2,498 employees focused on liquid biopsy and genomic testing for cancer detection.
MYRIAD GENETICS, INC.
Myriad Genetics, Inc. is a U.S. public company founded in 1991 with 2,700 employees specializing in genetic testing and personalized medicine.
ILLUMINA, INC.
Illumina, Inc. is a U.S. public company founded in 1998 with 8,625 employees that develops and manufactures DNA sequencing and genetic analysis systems.
QIAGEN N.V.
QIAGEN N.V. is a Dutch public company founded in 1984 with 5,500 employees providing molecular diagnostics and life sciences research tools.
EXACT SCIENCES CORPORATION
Exact Sciences Corporation is a U.S. private company founded in 1995 with 7,150 employees specializing in molecular diagnostics and cancer screening.
THERMO FISHER SCIENTIFIC INC.
Thermo Fisher Scientific Inc. is a U.S. public company founded in 1956 with 125,000 employees providing laboratory equipment, reagents, and analytical services.
GRAIL, INC.
GRAIL, Inc. is a U.S. public company founded in 2015 with 910 employees focused on early cancer detection through blood-based genomic testing.
BIO-RAD LABORATORIES, INC.
Bio-Rad Laboratories, Inc. is a U.S. public company founded in 1952 with 7,450 employees manufacturing clinical diagnostics and life science research products.
SYSMEX CORPORATION
Sysmex Corporation is a Japanese public company founded in 1968 with 10,861 employees specializing in in vitro diagnostics and hematology analyzers.
MDXHEALTH
MDxHealth is a Belgian public company founded in 2003 with 364 employees providing molecular diagnostics and epigenetic testing services.
PERSONALIS, INC.
Personalis, Inc. is a U.S. public company founded in 2011 with 260 employees offering whole genome sequencing and cancer genomics analysis.
Reasons to Buy this Report
- Market Size & Growth Projections : Access precise valuation data for the US market ($947.7M in 2025 growing to $1,660.1M by 2030) to inform investment decisions, product development timelines, and market entry strategies.
- US-Specific Growth Drivers : Understand the unique factors propelling US market growth including cancer incidence trends, precision medicine adoption rates, and healthcare system investments specific to the American market.
- Competitive Landscape Intelligence : Gain insights into the US competitive environment, including key players, market consolidation trends, and differentiation opportunities within the American liquid biopsy ecosystem.
- Regulatory & Reimbursement Insights : Obtain detailed analysis of US FDA approval pathways, insurance coverage decisions, and reimbursement trends that directly impact market adoption and revenue potential.
- Strategic Market Positioning : Develop data-driven strategies for market penetration, partnership opportunities, and product positioning tailored to the specific needs and dynamics of the US healthcare system.
Frequently asked questions
What is the current size of the US liquid biopsy market?
The US liquid biopsy market is valued at $947.7 million in 2025 and is projected to grow to $1,660.1 million by 2030.
What is the growth rate of the US liquid biopsy market?
The US liquid biopsy market is growing at a compound annual growth rate (CAGR) of 11.9% from 2025 to 2030.
What are the primary drivers of growth in the US liquid biopsy market?
Key drivers in the US include increasing cancer incidence, demand for non-invasive diagnostics, precision medicine adoption, favorable FDA regulations, and expanding reimbursement coverage.
Which applications are leading the US liquid biopsy market?
In the US, oncology remains the dominant application, with growing expansion into cardiology, prenatal screening, and infectious disease diagnostics.
How is the US regulatory environment supporting liquid biopsy market growth?
The US FDA has established expedited approval pathways for liquid biopsy tests, and increasing insurance coverage decisions are driving clinical adoption and market expansion.
RESEARCH METHODOLOGY
The study involved estimating activities to determine the current size of the liquid biopsy market. Exhaustive secondary research was done to collect information on the liquid biopsy industry. The next step was to validate these findings, assumptions, and sizing with industry experts across the value chain using primary research. Different approaches, such as top-down and bottom-up, were employed to estimate the total market size. After that, the market breakup and data triangulation procedures were used to estimate the market size of the segments and subsegments of the liquid biopsy market.
Secondary Research
In the secondary research process, various secondary sources such as annual reports, press releases & investor presentations of companies, white papers, certified publications, articles by recognized authors, gold-standard & silver-standard websites, regulatory bodies, and databases (such as D&B Hoovers, Bloomberg Business, and Factiva) were referred to identify and collect information for this study.
Primary Research
In the primary research process, various supply and demand sources were interviewed to obtain qualitative and quantitative information for this report. Primary sources were mainly industry experts from the core and related industries and preferred suppliers, manufacturers, distributors, service providers, technology developers, researchers, and organizations related to all segments of this industry’s value chain. In-depth interviews were conducted with primary respondents, including key industry participants, subject-matter experts, C-level executives of key market players, and industry consultants, to obtain and verify critical qualitative and quantitative information and assess prospects.
The following is a breakdown of the primary respondents:
Note 1: Others include sales, marketing, and product managers.
Note 2: Companies are classified into tiers based on their total revenues. As of 2024, Tier 1 = >USD 100 million, Tier 2 = USD 10 million to USD 100 million, and Tier 3 = < USD 10 million.
To know about the assumptions considered for the study, download the pdf brochure
| COMPANY NAME | DESIGNATION |
|---|---|
| QIAGEN | Sales Manager |
| F. Hoffmann-La Roche Ltd. | Sales Executive |
Market Size Estimation
Liquid biopsy is a non-invasive method for diagnosing and monitoring diseases. Blood or other body fluids are collected to analyze cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), or circulating tumor cells (CTCs).
Data Triangulation
After arriving at the overall market size by applying the abovementioned process, the total market was split into several segments and subsegments. To complete the overall market engineering process and arrive at the exact statistics for all segments and subsegments, data triangulation and market breakdown procedures were employed, wherever applicable. The data was triangulated by studying various factors and trends from both the demand & supply sides.
Market Definition
Both top-down and bottom-up approaches were used to estimate and validate the liquid biopsy market's total size. These methods were also used extensively to estimate the size of various subsegments in the market. The research methodology used to estimate the market size includes the following:
- The key players in the industry have been identified through extensive secondary research
- Primary and secondary research have determined the revenues of leading players operating in the liquid biopsy market.
- All percentage shares, splits, and breakdowns have been determined using secondary sources and verified through primary sources.
The research methodology used to estimate the market size includes the following:
Stakeholders
- Manufacturers & Distributors of Liquid Biopsy Products
- Hospitals & Diagnostic Centers
- Reference Laboratories
- R&D Companies
- Research Laboratories and Academic Institutes
- Liquid Biopsy Service Providers
- Government Associations
- Venture Capitalists & Investors
Report Objectives
- To define, describe, segment, and forecast the liquid biopsy market, by product & service, circulating biomarker type, technology, application, clinical application, sample type, end user, and region
- To provide detailed information regarding the major factors influencing market growth (drivers, restraints, opportunities, and challenges)
- To analyze micro markets with respect to individual growth trends, prospects, and contributions to the overall market
- To analyze market opportunities for stakeholders and provide details of the competitive landscape for key players
- To forecast the size of the market segments with respect to five regions, namely, North America, Europe, the Asia Pacific, Latin America, and the Middle East & Africa
- To profile the key players and comprehensively analyze their product portfolios, market positions, and core competencies
- To track and analyze company developments such as acquisitions, collaborations, partnerships, agreements, and product launches & approvals in the liquid biopsy market
- To benchmark players within the liquid biopsy market using the Company Evaluation Matrix framework, which analyzes market players on various parameters within the broad categories of business strategy, market share, and product offerings
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